Print 21 comment(s) - last by morphologia.. on Nov 8 at 3:52 PM

  (Source: Scientific American)
Human embryonic stem cells were injected into patients with spinal cord injuries

The first clinical trial for stem cell therapy began last Friday as a patient with spinal cord injuries received an injection of human embryonic stem cells. 

The trial is being ran and managed by Geron Corp., a developer of biopharmaceuticals for the treatment of cancer and chronic degenerative diseases. The treatment on their first patient took place in Atlanta, Georgia at the Shepherd Center, which is a spinal cord and brain injury center. 

Stem cells have come a long way since Hans Keirstead, a neurobiologist at the Reeve-Irvine Research Center at UC Irvine, first turned human embryonic stem cells into oligodendrocytes, which insulate nerve fibers with fatty myelin. This coating protects the damaged nerve cells enough to restore the ability for signals to "travel up and down the spine again." From this point, the stem cells were tested on animals, where rats with spinal cord damage regained partial ability to walk and run in their hind legs again. Now, researchers have moved on to the first human trial.

"All of that work, all of that money sent to the ivory towers is manifesting something," said Keirstead. "It's a real shot in the arm for the field."

The human trial, which is a so-called Phase I trial, is in its beginning stages and the plan is to strictly test the treatment for safety rather than effectiveness for right now. If the treatment proves to be safe, researchers will then test it for effectiveness. Its proven effectiveness could lead to the treatment of diabetes, spinal cord injuries and other neurodegenerative diseases. 

To test for safety, researchers are enrolling up to 10 patients with spinal cord injuries located between the third and 10th thoracic vertebrae. The stem cells are injected within 14 days after injury. 

The Shepherd Center in Atlanta will not be the only test site for the trial, though. Northwestern University near Chicago, as well as seven other centers, will be involved in this phase of the trial. The expected duration time of the human trial is two years after the last patient is registered. 

"I've got a couple of years of waking up and looking at the news every day, hoping and praying we're doing good for people and not bad," said Keirstead.

Researchers have high hopes that the stem cells will prove to be safe, and ultimately effective, but Keirstead noted that even if the treatment doesn't give human patients the ability to walk or run once again, it will allow them to be more in control of their bladder, bowel and sexual functions. The key is to "greatly improve their quality of life."

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Umbilical cord
By zippyzoo on 10/12/2010 10:27:59 AM , Rating: 2
I hope people don't start having kids just for the Umbilical cord.

RE: Umbilical cord
By Sazabi19 on 10/12/2010 10:44:57 AM , Rating: 2
No, they will have abortions for that.

scientologists will have the baby for the cord.

On a serious note, this seems to be pretty interresting, hope it works, looks promising.

RE: Umbilical cord
By quiksilvr on 10/12/2010 10:57:06 AM , Rating: 2
I actually hope they can get similar results getting stem cells from adult tissue. Something tells me embryos will get the public pissed and hinder their progress.

RE: Umbilical cord
By gamerk2 on 10/12/2010 11:14:49 AM , Rating: 4
You mean just like the public was pissed over in-vitro fertilization?

Fact is, once they find out it works, the public will do a 180; they always do.

RE: Umbilical cord
By Da W on 10/12/2010 11:40:33 AM , Rating: 2
They can clone stem cells now. Won't be ready for mass market for another 10 years, but, problem solved.

it's only a matter of time
By superPC on 10/12/10, Rating: 0
RE: it's only a matter of time
By choirbass on 10/12/2010 11:54:51 AM , Rating: 1
Hopefully they wont be able to ban it at all, they 'should' at least be aware that the fetus's would just be thrown away otherwise. So it's as if theyd instead prefer the fetus's to just be dead instead otherwise.. isn't that just a bit ironic?

RE: it's only a matter of time
By bigboxes on 10/12/2010 12:40:20 PM , Rating: 2
It's like rain on a sunny day.

RE: it's only a matter of time
By eskimospy on 10/12/2010 4:27:41 PM , Rating: 2
Something important about that though, from what I have read if we were to have a significant number of effective embryonic stem cell treatments out there along with intensive research it would be unlikely that they could be supplied purely with discarded embryos from in vitro clinics.

I personally have no problem with with it, but it's something people should know.

RE: it's only a matter of time
By morphologia on 11/8/2010 3:52:53 PM , Rating: 2
Sounds kind of alarmist, and likely doesn't take into account that - given proper funding and no religio-political stonewalling - stem cells are cultivated, grown in batches that propagate themselves. It's not like it's a 1-for-1, take a cell directly from an embryo and inject it into a patient kind of thing.

I would kinda have to wonder where you read what you read. There's bound to be a difference between references when comparing an article in a science journal and Ann Coulter's Facebook Page. :) Just sayin'.

RE: it's only a matter of time
By KCjoker on 10/12/2010 7:01:38 PM , Rating: 2
Can solve that problem really easy...get the embryonic stem cells from unbilical cords rather than from aborted fetus.

RE: it's only a matter of time
By sleepeeg3 on 10/12/2010 8:26:04 PM , Rating: 2
Use both. Why throw the baby out with the bath water?

We use dead people for organ donations - this is no different. Just require the mother's consent.

Seriously, help little Timmy walk again or... throw out a collection of dead cells, because someone has an attachment to them and leave Timmy to rot in a wheelchair for the rest of his life. This is a no brainer, to me.

Those of you living in the pipe dream that adult cells can be morphed into embryonic stem cells - it's likely similar to asking science to reverse engineer a dog into a cat! The genes have already been triggered and proteins have already been expressed. There is no reverse switch that can be flipped.

By FITCamaro on 10/12/2010 10:47:36 AM , Rating: 3
Let me know when they start building a Shakeys with them.

Seriously though, I hope it works out well. Would be great to be able to restore people's ability to walk.

RE: Yawn....
By Motoman on 10/12/2010 11:16:32 AM , Rating: 2

RE: Yawn....
By Reclaimer77 on 10/12/2010 11:42:52 AM , Rating: 2
That price? C'mon you're breaking my balls here, Chuck. Unlike the fetuses I wasn't born yesterday.

Not exactly the first?
By twhittet on 10/12/2010 12:17:38 PM , Rating: 2
Researchers Announce First Clinical Trial for Stem Cell Therapy

The first? Really? Am I ignorant, or is this title completely wrong? I've been hearing about stem cell techniques for a while now already being used to try and treat various ailments.

RE: Not exactly the first?
By Drag0nFire on 10/12/2010 2:21:39 PM , Rating: 2

This comes to mind. But it wasn't a full blown clinical trial, just a use of stem cell therapy. I think this is the first clinical trial of human embryonic stem cells in the US.

RE: Not exactly the first?
By twhittet on 10/12/2010 6:31:12 PM , Rating: 2
You used words the title omitted - the "embryonic" and "US" ones are probably pretty important.

Half expecting
By DigitalFreak on 10/12/2010 2:46:15 PM , Rating: 1
Considering the author, I was half expecting the last line to be something like "stem cells have been show to cause global warming".

RE: Half expecting
By Grabo on 10/12/2010 4:23:53 PM , Rating: 2
How with the branding iron..'just say the word'.

By yourwhiteshadow on 10/12/2010 8:07:23 PM , Rating: 2
some japanese lab, a year or two ago, was able to figure out exactly how you can induce pluripotency in almost ANY cell. although, my guess is the embryonic stem cells might be easier to come by and might be safer, so they ended up using the embryonic stem cells.

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