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Findings bring researchers closer to developing clinical trials, treating human diseases

In 2008, UCLA researchers announced that they had begun using animal trials to develop programmable stem cells. Now, scientists in Australia have announced that they have "reprogrammed" adult mouse fat cells and neural cells into stem cells that could be used in clinical trials for humans. 

Researchers at the Monash Institute of Medical Research developed induced pluripotent stem cells (iPS) that can differentiate into a variety of different cells.  Induced pluripotent stem cells, are believed to be identical to natural pluripotent stem cells, but have been developed by a "forced" expression of certain genes (cloning).  Natural pluripotent stem cells, such as embryonic stem cells, are in short supply and their access is restricted in the U.S., according to
 EurekaAlert!

"Induced pluripotent stem cells have revolutionized cell reprogramming," said Dr. Paul J. Verma, lead author of the study. "One challenge is to find the most appropriate cell for reprogramming. Our study demonstrated that both neural stem cells (NSCs) and adipose tissue-derived cells (ADCs) from adult mice expressed genetic pluripotency and could differentiate into the three germ layers, endoderm, mesoderm and ectoderm. The ADCs were the most amenable to reprogramming."

Verma added that iPS cells have been shown to have many of the hallmarks of embryonic stem cells.  Verma's team discovered while conducting the study that choosing which cells were best for reprogramming required looking at the ease of access and ease of derivation and growth of the cells in vitro.   They determined that it was likely that certain iPS cell lines will have a "higher propensity to differentiate into certain lineages (cell types)," according to Verma.

The research team concluded that ADCs represent a more clinically relevant cell type and that fat tissue can be easily accessed and grown easily and rapidly in cultures.  Their findings have been published in the journal 
Cell Transplantation.



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Mice obesity
By solarrocker on 7/27/2010 10:30:30 AM , Rating: 4
Well at least the liposuction these mice will get will fight mice obesity, and help the further research into stem cells.




RE: Mice obesity
By Smartless on 7/27/2010 5:58:44 PM , Rating: 2
For some reason, I thought of The Nutty Professor when he had that super fat mouse.

All in all, sounds too good to be true. Though they DID have to reprogram the cells.


Hmmm....
By cjohnson2136 on 7/27/2010 11:41:46 AM , Rating: 2
I think this is kind of interesting now someone correct me if I am reading this wrong but after reprogramming these mice cells would they be able to use these cells to grow say human parts like hearts and kidneys for transplants or am I just way off base




RE: Hmmm....
By sgw2n5 on 7/28/2010 12:49:17 AM , Rating: 2
No, not that far off base... but we won't see tech like that for decades.

In the short term, think about things like diabetes. Probably the very first use for stem cell therapy would be to introduce small blips of tissue to the pancreas that are actually capable of producing insulin.


RE: Hmmm....
By tmouse on 7/28/2010 7:39:46 AM , Rating: 2
No, no one is proposing the use of xenotransplants. Fat has long been known to be a source of undifferentiated mesenchymal cells. These cells are pluripotent, the "re-programming" affords them some measure of totipotency. The goal is to isolate and use human cells from the recipient or a family member to minimize or eliminate the need for post transplant immunosuppressive therapy.


This was planned .......
By Chaosforce on 7/27/2010 2:10:29 PM , Rating: 2
Think about it...... The USA currently has the highest amount of obesity. We find out how to make mice fat cells useful......all we need to do is make human fat cells useful.

The USA will then become the healthiest nation ever turning fat cells into new body parts.

Well played




RE: This was planned .......
By cjohnson2136 on 7/27/2010 2:20:03 PM , Rating: 3
I will donate my fat cells for science its a win/win. Scientists pay for liposuctions they get all the fat cells they want and Americans get skinny. Sounds like a good idea to me, even though it wouldn't make sense financially for scientists


Blasphemy!
By killerclick on 7/27/2010 9:07:21 PM , Rating: 1
I wish scientists would stop playing God. Why do they have to invent stuff, what's wrong with living 30 years?




RE: Blasphemy!
By CowKing on 7/28/2010 3:29:29 AM , Rating: 2
nothing, but I'd like to live another 30


The biggest losers next season
By tastyratz on 7/27/2010 11:40:08 AM , Rating: 2
Limb regeneration edition. Fat people turn into skinny starfish.
Tune in to see!




Old news
By HeavyB on 7/28/2010 9:30:12 AM , Rating: 2
Its funny to see the random stem cell link on Daily Tech. Usually its heralding a discover that is a me-too discovery spun off from a more critical and groundbreaking discovery that isn't covered in Dailytech. This article for instance is published in a very low impact factor journal since it is simply a me too follow-on. No slight on this journal, but its not exactly Science, Nature, or Cell.




I gotta ask
By YashBudini on 7/28/2010 12:25:00 AM , Rating: 1
OK, do these stem cells make me look fat?




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