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Sticky nanoparticles find tumor cells where they can be used to release drugs straight to the culprit

Building on past research with sticky nanoparticles, scientists at MIT have developed a method of delivering drugs straight to tumor cells. Previously the particles, which flow discretely through the bloodstream adhering only to tumorous cells, helped visualize tumors via magnetic resonance imaging. Now, using electromagnetic wave pulses, the same particles could be used to bomb the tumor cells with drugs.

The researches found that they could use the superparamagnetic properties of certain nanoparticles to activate, or in this case destroy, bonds holding drug molecules to the particles. Superparamagenetic materials have the property of giving off heat when exposed to a magnetic field.

The researchers used low-frequency wave pulses with frequencies between 350 and 400 kilohertz. These frequencies are much lower than much-feared microwaves, and pass harmlessly through the body, affecting only the nanoparticle delivery vehicles.

The microscopic drug tethers are made from strands of DNA. What makes the DNA molecule a good choice is that it can be created to melt with different amounts of heat based on strand lengths and coding. This could allow each particle to have several kinds of drug molecules attached to it, thus safely customizing treatment by simply modulated the pulse's frequency.

Though tests in the lab involving mice and implanted faux-tumors saturated with the drug bomb nanoparticles have been successful, the team of researchers is still doing work to guarantee that enough of the drug-ferrying particles will clump together inside of a tumor naturally to be effective.

"Our overall goal is to create multi-functional nanoparticles that home to a tumor, accumulate, and provide customizable remotely activated drug delivery right at the site of the disease," said Sangeeta Bhatia, M.D., Ph.D, an associate professor at the Harvard-MIT Division of Health Science and Technology and MIT's Department of Electrical Engineering and Computer Science.


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RE: Nanotech
By rushfan2006 on 11/20/2007 3:19:24 PM , Rating: 2
While I'd be flat out lying to everyone in this thread if I said I never thought that some companies really have the best interests in NOT curing a disease because of the profits in it. I'm also not so darn cynical to believe the ENTIRE world and EVERY SINGLE company and researcher on the planet would put the "holy dollar" above a cure.

Healthy cynicism I guess you can call my point of view - not naive to think the world is full of saints, but not quite cynical to think its only full of sinners either.

The one thing I will tell you I DO believe though -- the people who really do value a cure for the goodness of mankind are NOT the ones reaching the big time funds....its the companies that cater more for dragging out a cure to milk the profits of the treatment that get the funds.

Aside from that....Cancer is a much more complex a disease than Small Pox, Measles or Polio....orders of magnitude more complex. And cancer comes in many "varieties" unfortunately.

So I'll sit on the "line" on this one and call you paranoid folks "yeah they have a point", but you folks that think the world is all bunnies and roses "wow they are naive".

later.


RE: Nanotech
By Whedonic on 11/20/2007 8:20:11 PM , Rating: 2
Like you said, cancer is a very different kind of disease than polio and the others. Since it's caused by the malfunction of the body's own cells, as opposed to a pathogen, it makes the creation of preventative treatments an extremely difficult prospect. Personally, I'm thrilled to be making advances in treating tumor period. If someday someone thinks of a radical new way to prevent them altogether, even better.


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