Researchers Hope to Prevent HIV from Turning to AIDS with Anti-Inflammatory Drug
December 26, 2013 5:16 PM
comment(s) - last by
They also discovered how immune cell death occurs during an HIV infection
Scientists from the Gladstone Institutes have found that limiting (and possibly eventually blocking) the activity of a certain protein can help immune cells survive during
an HIV infection
, the research team has pinpointed each molecular event that occurs when an HIV infection leads to AIDS, which has lead to the use of an existing anti-inflammatory drug to stop that process from happening.
During an HIV infection, a protein known as IFI16 sniffs out fragments of HIV DNA in infected immune cells. This then activates the human enzyme caspase-1 and leads to pyroptosis, which is a highly inflammatory form of cell death.
From there, a repetitive cycle of abortive infection, cell death, inflammation and the pulling in of additional CD4 T-cells to the infection eventually destroys the immune system, leading to AIDS.
The latest study was built on earlier research in 2010 from the lab of Warner C. Greene, MD, PhD, who directs virology and immunology research at Gladstone. At that time, it was found that immune cells commit suicide in an attempt to protect the body after being infected. The suicide is to stop the virus from spreading.
However, this causes destruction of the immune system and causes AIDS.
That's why the more recent Gladstone study aimed to
understand this process
better. With that knowledge, they could possibly stop it from happening. This is key, since the death of CD4 T-cells are the main cause of AIDS.
The research team used human spleen, tonsil and lymph node tissue from HIV-infected patients for the study. They genetically manipulated CD4 T cells in the tissue to identify the DNA sensor that finds fragments of HIV's DNA.
This helped them find that reducing the activity of the protein IFI16 inhibited pyroptosis. However, they can't block it entirely until they know all of its functions.
The team is now entering a Phase 2 trial that will test an existing anti-inflammatory medicine's ability to block inflammation and pyroptosis in those with HIV. They hope that the drug, which targets the body and not the virus, will prevent drug resistance and offer an alternative to antiretroviral medications.
This article is over a month old, voting and posting comments is disabled
12/27/2013 6:21:37 AM
So the cells kill themselves to try to prevent the spread of the virus. By stopping that one stops that cause of AIDS but what about the rapid proliferation of more viruses? Is it possible to allow the viruses to proliferate without also leading to AIDS?
"Death Is Very Likely The Single Best Invention Of Life" -- Steve Jobs
Bone Marrow Transplants Rid Two Men of HIV
July 3, 2013, 1:04 PM
Gamers Decipher Structure of AIDS Enzyme
September 19, 2011, 4:28 PM
Campbell's Monkeys Found to Use Different Dialects to Describe Local Threats
December 22, 2014, 3:52 PM
Scientist Confirm Men are More Likely to Die in "Idiotic" Ways
December 17, 2014, 1:07 PM
Shoppers Surprised to Find Cards Against Humanity's Bullsh*t is Real Feces
December 16, 2014, 11:14 PM
Air Force Worries Hot Fuel Could Harm F-35, "Proactively" Paints Trucks Shiny
December 11, 2014, 9:06 AM
McDonald's is Testing Tablet-Based Burger Customization at 30 Franchises
December 10, 2014, 11:30 AM
Detroit Pulls Together Amidst Massive Blackout
December 2, 2014, 3:57 PM
Most Popular Articles
BlackBerry Classic Sells Out Online (Seriously, It Has) for North America
December 15, 2014, 7:07 PM
Paramount Bans Team America Screenings, Cowers Submissively to North Korea
December 18, 2014, 10:26 PM
Apple Abandons Russia; Ruinous Ruble Run Sees 25% Inflation in a Single Day
December 16, 2014, 5:40 PM
News Corp's Fox is Terrified of North Korea, Kills Upcoming Steve Carell Film
December 18, 2014, 4:09 PM
Android-Powered BLU Studio 7.0 Claims to be the "World's Largest Smartphone"
December 19, 2014, 2:40 PM
Latest Blog Posts
Sceptre Airs 27", 120 Hz. 1080p Monitor/HDTV w/ 5 ms Response Time for $220
Dec 3, 2014, 10:32 PM
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
More Blog Posts
Copyright 2014 DailyTech LLC. -
Terms, Conditions & Privacy Information