Researchers Hope to Prevent HIV from Turning to AIDS with Anti-Inflammatory Drug
December 26, 2013 5:16 PM
comment(s) - last by
They also discovered how immune cell death occurs during an HIV infection
Scientists from the Gladstone Institutes have found that limiting (and possibly eventually blocking) the activity of a certain protein can help immune cells survive during
an HIV infection
, the research team has pinpointed each molecular event that occurs when an HIV infection leads to AIDS, which has lead to the use of an existing anti-inflammatory drug to stop that process from happening.
During an HIV infection, a protein known as IFI16 sniffs out fragments of HIV DNA in infected immune cells. This then activates the human enzyme caspase-1 and leads to pyroptosis, which is a highly inflammatory form of cell death.
From there, a repetitive cycle of abortive infection, cell death, inflammation and the pulling in of additional CD4 T-cells to the infection eventually destroys the immune system, leading to AIDS.
The latest study was built on earlier research in 2010 from the lab of Warner C. Greene, MD, PhD, who directs virology and immunology research at Gladstone. At that time, it was found that immune cells commit suicide in an attempt to protect the body after being infected. The suicide is to stop the virus from spreading.
However, this causes destruction of the immune system and causes AIDS.
That's why the more recent Gladstone study aimed to
understand this process
better. With that knowledge, they could possibly stop it from happening. This is key, since the death of CD4 T-cells are the main cause of AIDS.
The research team used human spleen, tonsil and lymph node tissue from HIV-infected patients for the study. They genetically manipulated CD4 T cells in the tissue to identify the DNA sensor that finds fragments of HIV's DNA.
This helped them find that reducing the activity of the protein IFI16 inhibited pyroptosis. However, they can't block it entirely until they know all of its functions.
The team is now entering a Phase 2 trial that will test an existing anti-inflammatory medicine's ability to block inflammation and pyroptosis in those with HIV. They hope that the drug, which targets the body and not the virus, will prevent drug resistance and offer an alternative to antiretroviral medications.
This article is over a month old, voting and posting comments is disabled
12/27/2013 6:21:37 AM
So the cells kill themselves to try to prevent the spread of the virus. By stopping that one stops that cause of AIDS but what about the rapid proliferation of more viruses? Is it possible to allow the viruses to proliferate without also leading to AIDS?
"Nowadays, security guys break the Mac every single day. Every single day, they come out with a total exploit, your machine can be taken over totally. I dare anybody to do that once a month on the Windows machine." -- Bill Gates
Bone Marrow Transplants Rid Two Men of HIV
July 3, 2013, 1:04 PM
Gamers Decipher Structure of AIDS Enzyme
September 19, 2011, 4:28 PM
SpaceX Falcon 9-R Rocket Suffers Malfunction, Self-Destructs During Test Flight
August 23, 2014, 9:36 AM
Texas Chosen as Site for SpaceX's First Commercial Launchpad
August 5, 2014, 1:44 PM
South Carolina Prison Finds Crashed Drone Carrying Drugs, Phones
August 1, 2014, 2:49 PM
NASA's Mars 2020 Rover Gains Seven New Instruments for Exploration
August 1, 2014, 1:30 PM
NASA Opportunity Rover Breaks Record for Most Miles Traveled on Another Planet
July 29, 2014, 1:38 PM
Commercial Drones to Get Privacy Guidelines Via Executive Order
July 25, 2014, 5:34 PM
Most Popular Articles
Apple Scores Patents, Preps New Reversible USB Plug for iPhone 6 Connector
August 18, 2014, 1:32 PM
New AMD Fusion-Based Laptop From HP to Pack a Punch at $199
August 18, 2014, 4:13 PM
BlackBerry Reinvents Itself, Prepares for Potential Smartphone-Free Future
August 18, 2014, 7:51 PM
New Photos Show “Assembled” iPhone 6, Protruding Camera Ring
August 20, 2014, 2:32 PM
Lumia 830 Gets Major Upgrades Including New 20.1 Megapixel Toshiba Sensor
August 15, 2014, 6:00 PM
Latest Blog Posts
Space Terrorism is a Looming Threat For the United States
Apr 23, 2014, 7:47 PM
Facebook Aims to Provide Internet to "Every Person in the World" with Drones, Satellites
Apr 1, 2014, 10:20 AM
Retail Mobile Sites Experience Outages in Light of Simplexity's Bankruptcy
Mar 14, 2014, 8:48 AM
Tesla vs. BMW: Who Has the Safer EV?
Feb 1, 2014, 2:56 PM
Justice Leaks Details of Next HTC One Two Flagship Phone
Dec 5, 2013, 4:04 PM
More Blog Posts
Copyright 2014 DailyTech LLC. -
Terms, Conditions & Privacy Information