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They also discovered how immune cell death occurs during an HIV infection

Scientists from the Gladstone Institutes have found that limiting (and possibly eventually blocking) the activity of a certain protein can help immune cells survive during an HIV infection.
 
According to Science Daily, the research team has pinpointed each molecular event that occurs when an HIV infection leads to AIDS, which has lead to the use of an existing anti-inflammatory drug to stop that process from happening. 
 
During an HIV infection, a protein known as IFI16 sniffs out fragments of HIV DNA in infected immune cells. This then activates the human enzyme caspase-1 and leads to pyroptosis, which is a highly inflammatory form of cell death.
 
From there, a repetitive cycle of abortive infection, cell death, inflammation and the pulling in of additional CD4 T-cells to the infection eventually destroys the immune system, leading to AIDS. 
 
The latest study was built on earlier research in 2010 from the lab of Warner C. Greene, MD, PhD, who directs virology and immunology research at Gladstone. At that time, it was found that immune cells commit suicide in an attempt to protect the body after being infected. The suicide is to stop the virus from spreading. 
 
However, this causes destruction of the immune system and causes AIDS. 
 
That's why the more recent Gladstone study aimed to understand this process better. With that knowledge, they could possibly stop it from happening. This is key, since the death of CD4 T-cells are the main cause of AIDS. 
 
The research team used human spleen, tonsil and lymph node tissue from HIV-infected patients for the study. They genetically manipulated CD4 T cells in the tissue to identify the DNA sensor that finds fragments of HIV's DNA. 
 
This helped them find that reducing the activity of the protein IFI16 inhibited pyroptosis. However, they can't block it entirely until they know all of its functions.
 
The team is now entering a Phase 2 trial that will test an existing anti-inflammatory medicine's ability to block inflammation and pyroptosis in those with HIV. They hope that the drug, which targets the body and not the virus, will prevent drug resistance and offer an alternative to antiretroviral medications.

Source: Science Daily



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humira or embril?
By Samus on 12/27/2013 12:30:00 AM , Rating: 2
I wonder which blocker they will use, because if this works, it will give biotech one more reason to keep researching these type of much-needed drugs.

Dozens of diseases increase inflammation and inflammation itself causes dozens of syndromes. Who would have thought AIDS was related to cell inflammation?




RE: humira or embril?
By Reclaimer77 on 12/27/2013 8:18:10 AM , Rating: 2
quote:
Who would have thought AIDS was related to cell inflammation?


Well if you think about it, it makes sense. Don't flamers have a higher chance of getting HIV?

*giggles*

Ah come on, I couldn't help myself.


RE: humira or embril?
By puter_geek_01 on 12/27/2013 9:21:30 AM , Rating: 1
quote:
Well if you think about it, it makes sense. Don't flamers have a higher chance of getting HIV?
*giggles*


So, then you have HIV?
*giggles*


RE: humira or embril?
By superstition on 12/27/2013 8:25:25 PM , Rating: 2
Males have a higher chance of getting HIV and so do people who engage in anal sex due to penile abrasion of anal tissue.

So, if you want to argue that a certain segment of the population is superior because of lower HIV rates you'll have to argue in favor of lesbians.

You could even take your reasoning further and give male infants sex reassignment surgery. Removing penises is the best prevention method when it comes to sexual transmission of HIV.

I'm surprised the Gates Foundation didn't try this already, since it felt removing foreskins from Africans (the first step in the logical sequence toward penile removal) is a sound solution.


RE: humira or embril?
By superstition on 12/27/2013 8:30:50 PM , Rating: 2
quote:
Almost Half Of Heterosexuals Under 45 Have Anal Sex Says CDC Report

According to the National Survey of Family Growth, anal sex is really popular with heterosexuals.

Given that the study was done from 2006-2008, it is likely that the rates are higher.

So, you see, Reclaimer... for your moral superiority quest... you'll have to remove all penises, not just those of gay men.

How do you fancy your life after getting an artificial vagina?


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