Signs of Aging Could be Warded Off with New Compound
December 26, 2013 1:38 PM
Communication between the cell's nucleus and mitochondria is key
A new study shows that communication between a cell's nucleus and mitochondria is essential in warding off the negatives that
come with aging
, such as disease.
, helping to rebuild the broken communication between the nucleus and mitochondria has proven to reverse signs of aging in mammals (more specifically, mice). The study was led by Harvard Medical School Professor of Genetics David Sinclair and Ana Gomes, a postdoctoral scientist in the Sinclair lab.
The initial problem is that mitochondria (a cell's powerhouse that creates chemical energy) become increasingly dysfunctional over time leading to diseases like diabetes. The self-contained mitochondria, which have their own small genomes, have been linked to aging before.
Up until now, it was believed that aging can't be reversed because mutations in mitochondrial DNA cause age-related illnesses like Alzheimer's disease, and mutations can't be undone.
But the latest study focused on an important group of genes genes called sirtuins, and one of these genes -- SIRT1 -- is activated by a compound called resveratrol. When SIRT1 was removed, the mice certainly showed signs of aging, but the team was surprised to find that most mitochondrial proteins coming from the cell's nucleus remained at normal levels. Only those from the mitochondrial genome had decreased.
They saw that communication between the two was broken and accelerating age-related illnesses as a result. To correct it, they focused on a chemical called NAD, which keeps SIRT1 in check. SIRT1s job is to keep a molecule called HIF-1 away, which messes with communication between the nucleus and mitochondria. So if SIRT1 doesn't have enough NAD, it loses its ability to keep HIF-1 away and it destroys communication.
Without this communication, cell is unable to create energy and signs of aging occur.
The research team then used an endogenous compound that cells transform into NAD on two-year-old mice. After just one week, their tissue looked like that of six-month-old mice.
This repaired the broken communication and restored communication and mitochondrial function. The study states that giving this compound early enough (before excessive mutation accumulation) some aging could be reversed. It could also open up some doors and answer questions as to why cancer risk increases with age.
This isn't the first time Harvard researchers have worked on
age reversal techniques
. In 2010, Ronald DePinho, leader of the study and a scientist at Harvard Medical School, along with a group of Harvard researchers, discovered that an anti-aging therapy called telomere shortening has the potential to eliminate age-related issues like dementia and heart disease by rejuvenating old, worn out organs.
"So, I think the same thing of the music industry. They can't say that they're losing money, you know what I'm saying. They just probably don't have the same surplus that they had." -- Wu-Tang Clan founder RZA
Harvard Scientists Reverse Signs of Aging in Mice
November 29, 2010, 10:03 AM
PIQ ROBOTTM reveals its new artificial intelligence software
November 29, 2016, 12:59 AM
One more time - Happy Thanksgiving to Everyone Around the World
November 24, 2016, 4:00 AM
Google’s Smart Contact Lens Project gets halted for 2016
November 20, 2016, 7:00 AM
Cell Research Study shows African Americans have greater immune response to infection
November 10, 2016, 1:00 AM
UTHealth Clinical Trial Shows Progress Using Stem Cells to Treat Traumatic Brain Injury
November 8, 2016, 1:00 AM
Uber Partners with Circulation to Pilot Program Connecting Transportation and Digital Health Care
November 6, 2016, 5:00 AM
Most Popular Articles
Phillips 55’ 4K Smart TV – Is This Really a Deal? We Think So.
November 25, 2016, 9:44 AM
Sales Battle - Apple iPad Mini vs Samsung Galaxy Tab
November 29, 2016, 12:36 AM
Echo Dot is a Best Seller - Sold Out Until December 1, 2016.
November 26, 2016, 6:00 AM
PlayStation 4 Pro – 4K Console for 4K TVs
November 28, 2016, 1:00 AM
Star Wars Android Smartphones coming to a Japanese Galaxy Near You
November 26, 2016, 5:00 AM
Latest Blog Posts
Dec 2, 2016, 5:00 AM
Surface Ergonomic Keyboard
Dec 1, 2016, 3:01 AM
Chapeconense plane crash: Football rallies around Brazilian Team
Nov 30, 2016, 1:00 AM
How to Extends Your iPhone’s Battery Life
Nov 29, 2016, 12:49 AM
Nov 28, 2016, 1:12 AM
News: Fidel Castro
Nov 27, 2016, 5:00 AM
Nov 26, 2016, 5:00 AM
Changes in Social status affect the way genes turn on and off within immune cells.
Nov 25, 2016, 5:12 AM
Austrian far–right hopeful Hofer may back EU vote.
Nov 24, 2016, 4:00 AM
Final Fantasy XV Leaked Before Nov 29 Launch Date
Nov 23, 2016, 1:00 AM
Nov 22, 2016, 2:26 AM
Nov 21, 2016, 1:00 AM
HTC Makes Big Moves in China
Nov 20, 2016, 2:00 AM
Do you know who is the number one company in the word?
Nov 19, 2016, 5:30 AM
Foldable Cardboard ”EcoHelmet” wins James Dyson Award’s Top Prize
Nov 18, 2016, 2:39 AM
Scientists Discover Roundest Object Ever Spotted in Universe
Nov 17, 2016, 1:00 AM
Smallest Device Lets You Print Almost from Anywhere
Nov 16, 2016, 9:32 AM
Cancer Screening in the Community Is there a link between Cancer and Poverty?
Nov 15, 2016, 8:00 AM
Points to Consider when Buying Your New PC – Window 10 PC Buying Guide
Nov 14, 2016, 5:00 AM
More Blog Posts
Copyright 2016 DailyTech LLC. -
Terms, Conditions & Privacy Information