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Louis Picker, M.D.  (Source: OHSU)
The team is now trying to figure out why only half of the monkeys were successful in being treated while the other half were not

A new vaccine candidate has shown promise for HIV/AIDS patients by clearing a very aggressive form of the virus. 

Researchers from Oregon Health and Science University (OHSU) -- led by Dr. Louis Picker -- have developed a vaccine that specifically targeted the simian immunodeficiency virus (SIV), which is an aggressive form of HIV that turns into AIDS. 

HIV is tricky because it's difficult to clear completely from the body. While it can be undetectable in blood or tissue, it could hide in other places like organs and reappear later. SIV is even worse, replicating up to 100 times faster than HIV and can cause AIDS in only two years if it goes unnoticed. 

The team created the vaccine by using a cytomegalovirus (CMV), which is another virus just as persistent as SIV, but doesn't cause disease. The vaccine generated an immunoresponse that nearly mimicked the normal immunoresponse generated by CMV, creating effector memory T-cells that can search and destroy target cells. These cells remained in the system and were persistent, since the immunoresponse was similar to that of a normal CMV, and successfully targeted SIV-infected cells until the virus disappeared from the body.

This is important, because while other vaccines produce an immunoresponse too, the response diminishes over time.

The team tested the vaccine on monkeys with initial signs of infection, and found that about fifty percent of the monkeys tested showed signs of the infection fading before disappearing completely. 

"The virus got in, it infected some cells, moved about in various parts of the body, but it was subsequently cleared, so that by two or three years later the monkeys looked like normal monkeys," said Dr. Picker. "There's no evidence, even with the most sensitive tests, of the SIV virus still being there."

The team is now trying to figure out why only half of the monkeys were successful in being treated while the other half were not. But the OHSU researchers hope this vaccine candidate one day translates into a human form of the vaccine. 

Source: Gizmag

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The other half...
By Motoman on 9/13/2013 1:22:22 PM , Rating: 3
...unfortunately, the other half of the monkeys that aren't cured start dancing and singing One Direction songs non-stop.

Scientists fear that the rate of killing such OD-infected critters would instantly surpass the death rate of HIV/AIDS as even they themselves could only witness such a display for a couple minutes before beating the monkeys to death with office chairs and keyboards.

RE: The other half...
By Flunk on 9/13/2013 2:45:51 PM , Rating: 2
I don't know about that, if the right environment I bet you could make a lot of money with monkeys that sing One Direction songs. You just need the right marketing.

RE: The other half...
By Alexvrb on 9/13/2013 11:28:45 PM , Rating: 2
I think that would still be an improvement over One Direction singing their own songs.

RE: The other half...
By Piiman on 9/14/2013 10:22:28 AM , Rating: 4
They could call themselves "The Monkey's" ...oh wait

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