Type 1 Diabetes Drug "Teplizumab" Successful in Clinical Trial
August 8, 2013 2:39 PM
comment(s) - last by
It's mainly for pre-diabetics who don't have an advanced version of the disease
A new drug could give pre-diabetics the chance to combat the onset of full-blown
type 1 diabetes
The drug is called teplizumab, and it helped pre-diabetics maintain their current level of insulin production for two full years without the condition worsening. The drug seemed to be most beneficial for pre-diabetics rather than those with advanced type 1 diabetes.
The drug was developed by Jeffrey Bluestone, PhD, an immunologist at UC San Francisco, and Mary Clausen, Distinguished Professor at UC San Francisco. The clinical trial was led by Kevan Herold, MD, PhD, a professor of immunobiology and deputy director for translational science at Yale University.
Teplizumab works by using an antibody targeted against a molecule called CD3. The antibody binds to the immune system's T-cells and stops them from attacking beta cells. This is effective because the disease is caused by the body's immune system destroying insulin-producing beta cells in the pancreas.
"The benefits of treatment among the patients who still had moderately healthy insulin production suggests that the sooner we can detect the pre-diabetes condition and get this kind of drug onboard, the more people we can protect from the progressive damage caused by an autoimmune attack," said Bluestone.
Those who have advanced type 1 diabetes, however, didn't seem to benefit in the clinical trial. Some even lost half or more of their ability to produce insulin, which was likely due to differences in the "metabolic condition of the patients and in the severity of their disease."
For those who are past the point of pre-diabetes, don't fret. Just earlier this year, researchers from the Universitat Autònoma de Barcelona significantly improved the
blood glucose levels
of dogs with type 1 diabetes through a gene therapy that consists of a single session of multiple injections. These injections presented adeno-associated vectors (AAV) that both expressed the insulin gene, and also glucokinase (an enzyme that regulates an uptake of glucose from the blood). When both genes were expressed, the excess of blood sugar in type 1 diabetic dogs was controlled over a long-term period.
This article is over a month old, voting and posting comments is disabled
RE: Makes sense
8/9/2013 12:32:11 AM
Wonder what, or if, the side effects are?
RE: Makes sense
8/9/2013 8:44:12 AM
shouldn't it be obvious what the side effects are?
“Then they pop up and say ‘Hello, surprise! Give us your money or we will shut you down!' Screw them. Seriously, screw them. You can quote me on that.” -- Newegg Chief Legal Officer Lee Cheng referencing patent trolls
Gene Therapy Controls, Cures Type 1 Diabetes in Dogs
February 11, 2013, 1:59 PM
Artificial Pancreas Improves Glucose Control by 15%, Benefits Type 1 Diabetes Patients
January 30, 2013, 5:55 PM
Nail Polish May Soon be Able to Detect Date Rape Drugs
August 26, 2014, 7:57 AM
SpaceX Falcon 9-R Rocket Suffers Malfunction, Self-Destructs During Test Flight
August 23, 2014, 9:36 AM
Texas Chosen as Site for SpaceX's First Commercial Launchpad
August 5, 2014, 1:44 PM
South Carolina Prison Finds Crashed Drone Carrying Drugs, Phones
August 1, 2014, 2:49 PM
NASA's Mars 2020 Rover Gains Seven New Instruments for Exploration
August 1, 2014, 1:30 PM
NASA Opportunity Rover Breaks Record for Most Miles Traveled on Another Planet
July 29, 2014, 1:38 PM
Most Popular Articles
Dell Announces "World's Thinnest" Tablet: The Venue 8 7000 Series
September 11, 2014, 8:51 AM
Apple Announces Its Smartwatch: The $349 Apple Watch
September 9, 2014, 2:09 PM
Quick Note: Buy an Xbox One Sept 7-13, Get a Free Game
September 4, 2014, 10:42 AM
Quick Note: Microsoft to Ditch Windows Phone, Nokia Branding
September 10, 2014, 2:14 PM
Apple Announces 4.7" iPhone 6, 5.5" iPhone 6 Plus
September 9, 2014, 1:45 PM
Latest Blog Posts
Space Terrorism is a Looming Threat For the United States
Apr 23, 2014, 7:47 PM
Facebook Aims to Provide Internet to "Every Person in the World" with Drones, Satellites
Apr 1, 2014, 10:20 AM
Retail Mobile Sites Experience Outages in Light of Simplexity's Bankruptcy
Mar 14, 2014, 8:48 AM
Tesla vs. BMW: Who Has the Safer EV?
Feb 1, 2014, 2:56 PM
Justice Leaks Details of Next HTC One Two Flagship Phone
Dec 5, 2013, 4:04 PM
More Blog Posts
Copyright 2014 DailyTech LLC. -
Terms, Conditions & Privacy Information