Study: New DNA Vaccine Shuts Down Immune Cells that Cause Type 1 Diabetes
July 1, 2013 5:05 PM
comment(s) - last by
It leaves the rest of the immune system alone, though
Type 1 diabetes is a lifelong disease, but researchers at Stanford University are hoping to eliminate the effects of the disease -- and eventually cure it -- with a new vaccine.
Researchers from the Stanford School of Medicine -- led by Lawrence Steinman, MD, professor of pediatrics and of neurology and neurological sciences at Stanford -- have created a DNA vaccine that fights
type 1 diabetes
by targeting only a certain population of cells in the immune system without destroying the whole thing.
The vaccine consists of an altered piece of DNA, which holds the proinsulin gene. Beta cells, which are the only cells that make insulin in the body, start out as proinsulin precursor proteins. The beta cells, like all cells, display small pieces of the proteins they make on their surfaces called peptides, and the proinsulin peptides on the surface of beta cells cause misdirected CD8 cells (which are immune cells that patrol the cell surfaces for foreign peptides) to attack the beta cells.
The new DNA vaccine seeks out CD8 cells
targeting proinsulin; not all CD8 cells. If the vaccine had shut down the normal behavior of all CD8 cells, it would interfere with the patient's immune system and stop their bodies from being able to fight off infections and serious issues like cancer. Hence, shutting the whole system down isn't a better option.
That's why the vaccine only targets proinsulin-attacking CD8 cells and stops them from destroying beta cells while leaving everything else alone.
To test the vaccine, the research team recruited 80 type 1 diabetic patients that
required insulin therapy
. They divided the patients into five different groups, where four received different doses of the vaccine and one received a placebo.
Over the course of 12 weeks, the researchers measured levels of C-peptide in the patients, which is a piece of proinsulin that is cut off when insulin is pulled out of the proinsulin molecule. C-peptide is thought to fight off diabetic complications, such as eye and kidney damage.
The team checked the C-peptide levels before they began, then at five and 15 weeks, and then six, nine, 12, 18 and 24 months after starting on the vaccination. During these checks, blood was drawn 30, 60, 90 and 120 minutes after patients drank a modified milkshake.
According to results, levels of proinsulin-targeting CD8 cells were significantly depleted in patients who received the vaccine, compared with those getting placebo. However, other CD8 cells remained intact and left alone. Patients on the vaccine either had the same C-peptide levels or even increased levels, which would help them fight off diabetic complications later in life.
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RE: I am Legend
7/2/2013 5:29:35 AM
He probably means to say that its preferable to find a naturally occurring remedy or lifestyle change rather than monkeying with human genetics before we have a backup option to the human body. Ex full synthetic and be done with disease, or the ability to grow something from scratch. Ok, I'm going to bed now before I get charged with destruction of government property. (sun burn). Yes, its happened.
RE: I am Legend
7/2/2013 12:09:59 PM
Type I diabetes is an auto-immune disorder that is usually (though not always) genetic in origen. There is no "lifestyle change" or "naturally occurring" remedy to cure it. You have to get rid of or alter the cells in the immune system that attack insulin-producing cells, which requires exotic methods to accomplish.
Maybe there are unintended consequences of this treatment, but who's to say that a "natural" treatment wouldn't have any? The important thing here is that this is a major step towards curing a disease that afflicts millions of people.
"And boy have we patented it!" -- Steve Jobs, Macworld 2007
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