Report Claims Global Warming is Increasing Brain Eating Amoebas
June 28, 2013 8:00 AM
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Infections are mildly correlated to population, with little evidence supporting warming hypothesis from non-experts
is one nasty microorganism. A member of the amoeba family, it resides in inland bodies of water in North America. It attacks humans -- particularly young men. An alarmist report, backed by a non-expert, is proclaiming that
may drive infections. Is this the case? Let's examine the facts.
The amoeba enters via the nose and works its way into the brain where it multiplies, slowly killing the victim. The time between infection and onset of symptoms is nearly a week and the symptoms are rather nondescript at first -- headaches, vomiting, and confusion.
Once infected, the host's
brain is literally eaten alive
. The disease is referred to as PAM (primary amebic meningoencephalitis).
[Image Source: Trevor Haggie]
Since 1962 only one patient (out of 128 confirmed infections) has survived and infection by the deadly parasite -- a 99 percent fatality rate. In most cases, the infection isn't even caught. Vanderbilt University medical school professor William Schaffner describes diagnosis as more luck than any other factor, remarking, "It’s not something that’s necessarily touched on in medical school. You have to really probe what patients were doing in the last several days, you have to ask if they were swimming. Honestly, an accurate diagnosis is basically serendipity."
is a deadly amoeba. [Image Source: CDC]
Given the low rate of infections -- and even lower rate of infections that are recognized before death -- treatment is more guesswork than science. Patients are administered a cocktail of antibacterial and antifungal compounds. Jonathan Yoder, an expert with the
Centers for Disease Control
’s division of parasitic diseases, describes in
a recent interview
, "That’s very frustrating for us. Did the treatment only work that one time? Does it work at all? Would other treatments work better? We just don’t know."
The potentially bad news is that PAM incidents -- at least correctly diagnosed ones -- are on the rise. Here's a graph with the # of deaths and state of the death by year:
PAM incidents by year [click to enlarge] [Image Source: CDC]
Notice that there were big jumps in confirmed infections in the 1970s and in the 2000s. So what's to blame?
II. Hypothesis: Warming is To Blame
has run a rather alarming piece entitled "
Brain-eating amoebas thrive in US lakes as global warming heats waterways
". To be fair they have a source for this --
Bowling Green State University
(Ohio) Sports and Leisure professor. Now Professor Heggie has no professional degrees in epidemiology or microbiology, but he tracks
infections as a hobby.
Yet, he speaks authoritatively, telling
, "The climate is changing, and let me tell you, so is this. If warm weather keeps up, I think we’ll see N. fowleri popping up farther and farther north."
Is warming to blame for the rise in infections? [Image Source: Tehran Times]
's Katie Drummond writes, "That speculation seems to be reinforced by recent cases of PAM, once a health woe confined to fresh water in southern states like Texas and Arizona. In Minnesota, public health officials were stunned to see two fatalities caused by N. fowleri — both young children — in 2010 and 2012. The cases are the only in state history, and occurred about 550 miles farther north than any previous reported PAM fatality in the US."
The author is correct, two infections have occurred in Minnesota which are the only infections reported in Northern states. But note that nowhere in the piece do the real experts -- Dr. Schaffner and Professor Yoder -- suggest that the rise in infections is related to warming (a hypothesis fielded by Professor Heggie alone). Let's dig into whether the rise in infections is truly correlated with warming.
III. The Boy Who Cried Warming (Hypothesis Invalidated)
Let us consider factors that could drive rates of confirmed infections up (along with a suggestion on how it might impact infection rates):
resides in water 86 degrees and up)
National population (more people would mean more infections, you'd expect)
Urban population (people use more crowded water resources)
Papers on the disease (more interest means more awareness, more confirmations)
Mutations (hardy strains survive in new habitats)
Let's acknowledge, but toss out #5, as we don't have the data to track that.
To analyze this, let's first compile the rate of infections per decade which peaked from 2002-2011, thus far [Sources:
]. For #1 let's take the average rise in surface air temperatures over the U.S. on a decade averaged basis [
]. For #2 we can use widely available census data [
]. For #3 we can use data from a world clearinghouse [
]. For #4 we can use Thomson Reuters "Web of Knowledge" Product.
With this data in hand, we simply analyze the correlation of cases per decade versus influence and here is what we find:
Actually climate change has the
correlation of any examined factor. The strongest correlations are with the population itself (around 0.86), and more specifically with the urban population (around 0.85).
I'd be inclined not to discount the relatively high correlation to the amount of peer-reviewed research published per decade, though it's hard to say whether this is a cause or an effect. Ironically
report hints at this. Mr. Yoder comments, "I'll swear my life to that — this is being wrongly diagnosed [for bacterial meningitis]. If someone died of meningitis, I’d suggest looking into that case a little more closely ... and looking at where the brain was eaten away at."
A 1970 study shows that for every 16,000 cases of bacterial meningitis, one was actually a misdiagnosed case of PAM.
But even these correlations are highly speculative when one looks at the graph of change in the various variables, scaled to change in PAM infections per decade:
Is there an outside possibility that warming is having some affect on PAM? Perhaps, but it seems unlikely, given that most cases remain in southern states, some of which have actually cooled (like Georgia):
[Image Source: EPA]
Furthermore, while Minnesota is among the states to have warmed more over the past century, Michigan and the Eastern states have warmed at least as much -- yet had no cases. Michigan and Minnesota have roughly the same number of lakes [Source:
] over 100 acres -- yet there were no infections in Michigan.
In other words, while
is certainly a poorly understood disease and frightening public health threat. But to blame warming for this disease (or publicize such claims) is highly dubious. Quite simply put, the correlation is weak, as is the supporting evidence for such a claim. It appears this is yet another case of crying wolf.
CDC via Epidemiology and Infection [abstract]
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6/28/2013 9:04:05 AM
Jason, you've hit a new low.
Is this supposed to be legit science or statistical analysis. I can tell you this is a laughing stock either way. The variables doesn't even make sense. There was no test for multicollinearity?
Warming: since you mentioned 86F for this organism, you really use an annual % of areas that surpass 86F instead of average temp change.
National population: more people means more infections but this depends if you want to find "rate" or "number".
Urban population: it makes more sense to use % of population is urban instead of just plain urban pop.
Mutations: how could you possibly find data for this? there's no way you know how many mutations there has been.
I can see problems in multicollinearity in the variables. For example, your national population and urban population will be highly correlated. Seriously, I've seen better analysis done by a sophomore in college.
The results are laughable. I wonder if you even know how multiple regression work. Where is your p-value? that's more important than R^2. T-test? what is the highest contributing variable?
This is just so dumb and far out that if anyone even take this article seriously, they've got to be a nutcase .
6/28/2013 10:01:57 AM
Eh, his method may not have been the most thorough, but look at the who he was debunking. It's not like he was trying to dismiss a scientific publication from a renowned microbiologist. He was debunking a story ran by The Verge that used a Sports and Leisure professor for its source.
While I agree that his analysis would fall quite short of the mark to be taken seriously in scientific journals, he put a hell of a lot more effort into it than the report he is debunking. Further, his conclusions, given what data is presented, make more sense than the alarmist opinions presented in the report he is debunking. That all said, this is not a scientific publication, it is a DailyTech news article and should be treated as such.
6/28/2013 11:03:05 AM
You would figure he would put the entire NOVA chart instead of just R^2. I'm sure if he did, it would look really bad. Regardless of whatever the verge or jason is trying to prove, they both fell far short in both results and sensationalism.
If you want to prove this organism has anything or nothing to do with global warming then you have to prove it in a lab. You can easily get repeatable results for both reproduction and infection rates in lab conditions. It's quite easy especially when they're trying to prove temperature has something to do with it. Instead we get what is less than an amateur attempt at quantitative statistical analysis. Since this is such a rare health problem, the numbers are too small to even attempt to use statistics. It was already invalid before the attempt was made.
7/1/2013 1:28:32 AM
Plot twist - Mick has the amoebas himself!
"I'd be pissed too, but you didn't have to go all Minority Report on his ass!" -- Jon Stewart on police raiding Gizmodo editor Jason Chen's home
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