New Nanosponges Help Fight Infection, Animal Poison
April 15, 2013 1:25 PM
comment(s) - last by
Sponges remove toxins from the bloodstream which punch holes in human cells
Bit by a snake?
might soon be what the doctor orders.
A large variety of animal venoms share a class of dangerous compounds called pore-forming
. Bee stings, the bites of some venomous snakes, and even the
drug-resistant "super-bug" MRSA
(an infectious bacteria) all contain chemicals of this class, which can cause death in mammals in sufficient doses. The toxins puncture cell membranes causing an influx of ions and cell death.
The new nanosponges soak of the dangerous chemical. In a test mice were given a fatal dose of alpha-haemolysin -- a pore-forming toxin -- produced by MRSA. The mice that were "inoculated" with a dose of nanosponges survived thanks to the helpful little sponges.
To maintain biocompatibility -- to prevent the host's immune system from attacking the helper sponges -- they are "cloaked" in red blood cell membranes with sugar profiles compatible to the host. This technology was developed by Liangfang Zhang's lab at
UC San Diego
who invented the cloaking technology also masterminded the nanosponge application. The cloaking technology proved opportune, as red blood cells are one of the primary targets of the class of toxins.
Wrapped in segments of red blood cell (RBC) membrane and biocompatible polymers, the finished nanosponges measure 85 nanometers in diameter. The RBC skins are extracted via centrifuging and then treatment with a swelling solution. The next step is to coat the nanoparticles, which are about 1/3,000th of the size of a red blood cell.
The therapy uses membranes from the patient's own red blood cells. [Image Source: Deskarti]
Even at a 70:1 ratio of toxin to nanosponge, the tiny nanoparticles effectively blocked the toxin in mice by outnumbering the standard RBC targets. One nanosponge can soak up to 85 alpha-haemolysin toxin produced by MRSA, 30 stretpolysin-O toxins and 850 melittin monomers, which are part of bee venom.
The nanosponges are sequestered by the liver, which has more robust cells that can withstand and break down the toxic contents. The half-life of the toxin-soaked nanosponges is around 40 hours, according to the researchers.
Electron microscopy images of the toxin-blocking nanosponges. [Image Source: UCSD]
[press release], "This is a new way to remove toxins from the bloodstream. Instead of creating specific treatments for individual toxins, we are developing a platform that can neutralize toxins caused by a wide range of pathogens, including MRSA and other antibiotic resistant bacteria."
The findings of the study on rodents
[abstract] in the prestigious peer-reviewed journal
His team is already looking ahead to clinical trials on humans; the drug has great potential due to its ubiquity -- most antivenoms only target one or a handful of toxins.
UC San Diego [Press Release]
This article is over a month old, voting and posting comments is disabled
4/17/2013 8:39:02 AM
Hmmm, wondering if this technology might finally be a method of eliminating (or at least significantly reducing) the horrible process after a box jelly sting. I just don't know if this can help in the case of a cytokine storm as in the case of the jelly. Anyone know?
"We don't know how to make a $500 computer that's not a piece of junk." -- Apple CEO Steve Jobs
Boron/Carbon Nanosponges Used to Absorb Oil from Water
April 17, 2012, 12:04 PM
Nerve Toxins Destroyed by Plant-Derived Bioscavenging Molecules
November 25, 2010, 10:01 AM
Creepy Crawlers Could Help Fight Superbugs
September 8, 2010, 10:09 AM
Smartphone STD Scanner Dongle Can Detect HIV in Just 15 Minutes
February 26, 2015, 11:04 AM
Bill Gates Plugs GMOs to Reduce Starvation in Africa
February 24, 2015, 10:12 PM
Cool Nature Video: Crazy Coconut Octopus Braves Dry Land to Capture Crab
February 24, 2015, 4:18 PM
MIT Creates Injectable Self-Healing Nanoparticle Hydrogel for Cancer Treatment
February 23, 2015, 9:37 AM
Amp EVs' Workhorse and HorseFly Duo Challenge Amazon to Delivery Drone Duel
February 20, 2015, 3:56 AM
DARPA Awards Boeing Contract to Test Jet Based Satellite Launches
February 19, 2015, 11:30 AM
Most Popular Articles
Modern Glass (Windows 7 Aero Glass + Modern UI) Style is Coming to Windows 10
February 19, 2015, 1:05 PM
Amid Tight Race w/ Evernote, Microsoft's OneNote Goes (Even More) Free, Adds Fresh Features
February 23, 2015, 11:15 AM
EDITORIAL: Board Wants to Anoint America World Police w/ Global Warrant Power
February 20, 2015, 9:10 AM
Quick Note: Microsoft Gives Dropbox Users Extra 100 GB of Free OneDrive Storage
February 20, 2015, 9:48 AM
NVIDIA Bows to Outraged Overclockers, Will Restore Feature in Upcoming Driver
February 23, 2015, 12:30 PM
Latest Blog Posts
Sceptre Airs 27", 120 Hz. 1080p Monitor/HDTV w/ 5 ms Response Time for $220
Dec 3, 2014, 10:32 PM
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
More Blog Posts
Copyright 2015 DailyTech LLC. -
Terms, Conditions & Privacy Information