Researchers Use Page Rank Algorithm to Study Cancer
April 2, 2013 8:43 AM
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Modeling will help researchers predict where cancer might spread in patients, better screen them
can be a particularly deadly one as it can quickly spread to some parts of the body once it metastasizes (once tumor cells enter the bloodstream). But the process of metastasis is poorly understood.
Looking to model the process researched at the
University of Southern California
emulated the underlying mechanics of Google Inc.'s (
Page Rank algorithm
and the Viterbi Algorithm (another popular algorithm used in GSM cell phone networks using probabilistic Markov chain-driven convolution) to model the spread of the cancer.
They found that the adrenal gland and kidney act as lung cancer cell "spreaders" distributing tumor cells around the body. By contrast, when infiltrated by tumor cells the regional lymph nodes, liver, and bones acted as "sponges" and did not significantly spread around the disease.
To get data for the model, the researchers used autopsy information on essentially untreated patients. They used data from 163 lung cancer patients in the New England area, from 1914 to 1943. In this era effective radiation therapies and chemotherapies did not exist, so the disease essentially spread unchecked.
Researchers have used Google's PageRank algorithm to help model the seemingly unpredictable spread of metastatsized lung cancer cells. [Image Source: SPL]
There's growing interest in the medical field to use mathematical models to predict the spread of cancer. By using past data, doctors treating a particular kind of cancer can keep their eye out for where it might spread -- and which locations it would be most dangerous for it to spread to.
School of Engineering
, Ph.D, comments, "This research [using PageRank to model cancer] demonstrates how similar the Internet is to a living organism. The same types of tools that help us understand the spread of information through the web can help us understand the spread of cancer through the human body."
The study on the work has been
[abstract] in the peer-reviewed journal
. It was funded by the
National Cancer Institute
Gates Millennium Fellowship Program
the Bill and Melinda Gates Foundation
Cancer Research [abstract]
USC [press release]
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So what is the discovery?
4/2/2013 9:21:03 AM
"They found that the adrenal gland and kidney act as lung cancer cell "spreaders" distributing tumor cells around the body. By contrast, when infiltrated by tumor cells the regional lymph nodes, liver, and bones acted as "sponges" and did not significantly spread around the disease."
Ok yes, the adrenal gland produces over 50 hormones and distribute it throughout the body so you can say it distribute cancer. In fact, that is how it spreads for people with lung cancer. They see their cancer spread from one lymph node to another. The the lymph nodes are essential a filter and a police station since it has T cells, B cells and macrophages. Lymph nodes does significantly slow down spread of cancer. However, it is not a perfect system so the cancer will spread in time if treatment does not work.
So this is not a discovery but more of confirmation.
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