Gene Therapy Controls, Cures Type 1 Diabetes in Dogs
February 11, 2013 1:59 PM
comment(s) - last by
The research team and the cured dogs
(Source: Pierre Caufap)
Only one session of injections cured the dogs for over four years
Researchers from Barcelona have developed a new gene therapy that significantly improved the
blood glucose levels
of dogs with type 1 diabetes -- and could potentially be a cure.
The team was made up of researchers from the Universitat Autònoma de Barcelona, and was led by Fàtima Bosch.
The new gene therapy consists of a single session of multiple injections. These injections presented adeno-associated vectors (AAV) that both expressed the insulin gene, and also glucokinase (an enzyme that regulates an uptake of glucose from the blood). When both genes were expressed, the excess of blood sugar in type 1 diabetic dogs was controlled over a long-term period.
The adeno-associated vectors were derived from non-pathogenic viruses, and simply transferred the two genes to the muscle of the dogs once injected.
This gene therapy was tested on dogs, who received a single administration of the gene therapy. Results showed that the dogs' blood glucose levels were controlled all the time, whether they were eating or fasting. The dogs didn't have any episodes of hypoglycemia, either, which is when blood glucose levels drop too low.
The dogs in the study maintained normal blood glucose levels for more than four years after the injections without requiring any more sessions, and still show no signs of the disease returning. They didn't experience any secondary complications associated with type 1 diabetes in that time period, either.
Since AAV vectors have been previously introduced into skeletal muscle treatments, getting this gene therapy into a clinical setting shouldn't be too difficult. Once this has been accomplished for
type 1 diabetic
companion animals, it should move on to humans.
This article is over a month old, voting and posting comments is disabled
RE: gene therapy
2/11/2013 11:37:28 PM
Viral vectors can cause cancer if they insert at a gene that regulates the cell cycle and tumor proliferation. That's what killed gene therapy about 15 years back.
"Google fired a shot heard 'round the world, and now a second American company has answered the call to defend the rights of the Chinese people." -- Rep. Christopher H. Smith (R-N.J.)
Artificial Pancreas Improves Glucose Control by 15%, Benefits Type 1 Diabetes Patients
January 30, 2013, 5:55 PM
Researchers Use Stem Cells to Treat Diabetes in Mice
February 21, 2008, 1:05 PM
Quick Note: Drone Loses Fight to the Death With Kangaroo
December 23, 2014, 3:28 PM
Campbell's Monkeys Found to Use Different Dialects to Describe Local Threats
December 22, 2014, 3:52 PM
Scientist Confirm Men are More Likely to Die in "Idiotic" Ways
December 17, 2014, 1:07 PM
Shoppers Surprised to Find Cards Against Humanity's Bullsh*t is Real Feces
December 16, 2014, 11:14 PM
Air Force Worries Hot Fuel Could Harm F-35, "Proactively" Paints Trucks Shiny
December 11, 2014, 9:06 AM
McDonald's is Testing Tablet-Based Burger Customization at 30 Franchises
December 10, 2014, 11:30 AM
Most Popular Articles
Miyamoto: Nintendo is Prepping Successor to Troubled Wii U
December 22, 2014, 6:28 PM
Amazon's Kindle Fire HDX 8.9 Drops to $299 (30 Percent Off) for a Day
December 22, 2014, 10:57 AM
Airbus A350 XWB Passenger Jet Takes Off, First Unit Delivered to Qatar Airlines
December 22, 2014, 1:22 PM
Microsoft, Google Back The Interview, North Korea Vows Attacks on America
December 24, 2014, 4:25 PM
Nokia's Sweet $250 Android Lollipop N1 Tablet is Rumored for Jan. 7 China Launch
December 24, 2014, 1:45 PM
Latest Blog Posts
Sceptre Airs 27", 120 Hz. 1080p Monitor/HDTV w/ 5 ms Response Time for $220
Dec 3, 2014, 10:32 PM
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
More Blog Posts
Copyright 2014 DailyTech LLC. -
Terms, Conditions & Privacy Information