Gene Therapy Controls, Cures Type 1 Diabetes in Dogs
February 11, 2013 1:59 PM
comment(s) - last by
The research team and the cured dogs
(Source: Pierre Caufap)
Only one session of injections cured the dogs for over four years
Researchers from Barcelona have developed a new gene therapy that significantly improved the
blood glucose levels
of dogs with type 1 diabetes -- and could potentially be a cure.
The team was made up of researchers from the Universitat Autònoma de Barcelona, and was led by Fàtima Bosch.
The new gene therapy consists of a single session of multiple injections. These injections presented adeno-associated vectors (AAV) that both expressed the insulin gene, and also glucokinase (an enzyme that regulates an uptake of glucose from the blood). When both genes were expressed, the excess of blood sugar in type 1 diabetic dogs was controlled over a long-term period.
The adeno-associated vectors were derived from non-pathogenic viruses, and simply transferred the two genes to the muscle of the dogs once injected.
This gene therapy was tested on dogs, who received a single administration of the gene therapy. Results showed that the dogs' blood glucose levels were controlled all the time, whether they were eating or fasting. The dogs didn't have any episodes of hypoglycemia, either, which is when blood glucose levels drop too low.
The dogs in the study maintained normal blood glucose levels for more than four years after the injections without requiring any more sessions, and still show no signs of the disease returning. They didn't experience any secondary complications associated with type 1 diabetes in that time period, either.
Since AAV vectors have been previously introduced into skeletal muscle treatments, getting this gene therapy into a clinical setting shouldn't be too difficult. Once this has been accomplished for
type 1 diabetic
companion animals, it should move on to humans.
This article is over a month old, voting and posting comments is disabled
2/11/2013 5:03:40 PM
As USUAL, Instead of giving some constructive comments.. We AGAIN will be spammed with Internet Super smart people, who GOOGLE the subject matter.. Look up the WIKKI of said Subject and produce their own IDIOT Comments..
VERSUS.. At least recognizing the fact that someone SMARTER than they are, are at least TRYING to do something.. How about seeing the fact, that SOMEONE is trying to cure something that effects MILLIONS of People.. Oh no.. Someone criticizes comment, without offering JACK.. Internet Smart pukes..
BUT -- This is awesome.. At last.. there is some headwind.. TONS of FAT BODIES that have this disease, may someday have a cure.. POSSIBLY an Immunization..
RE: As Usual
2/11/2013 5:35:50 PM
Ok, so first off, their comments aren't hyper technical in the least.
Secondly, their comments are idiotic; yours, however, is.
Lastly, fat bodies? Type I diabetes is childhood onset diabetes and has little to nothing to do with weight. So, nice one there Poindexter.
RE: As Usual
2/11/2013 5:37:21 PM
*aren't idiotic. AREN'T. Curse you Dailytech and your lack of edit feature!
"A lot of people pay zero for the cellphone ... That's what it's worth." -- Apple Chief Operating Officer Timothy Cook
Artificial Pancreas Improves Glucose Control by 15%, Benefits Type 1 Diabetes Patients
January 30, 2013, 5:55 PM
Researchers Use Stem Cells to Treat Diabetes in Mice
February 21, 2008, 1:05 PM
Creationists are Mad About Google Doodle Depicting Evolution
November 24, 2015, 8:48 PM
DHS and TSA: Whoops, We Missed That 73 Airport Employees May be Terrorists
November 19, 2015, 2:16 PM
Star Wars Spinoff Film "Rogue One", Theme Park Attractions Announced
August 17, 2015, 12:20 PM
SpaceX Falcon 9's Seventh Supply Mission to ISS Ends w/ Fiery Stage 1 Explosion
June 28, 2015, 1:10 PM
Cool Science Video: Glowing Millipede Prowls the Nevada Desert
May 18, 2015, 12:00 PM
Newly Discovered Costa Rican Glass Frog is Kermit's Doppelgänger
April 22, 2015, 11:26 AM
Latest Blog Posts
Sceptre Airs 27", 120 Hz. 1080p Monitor/HDTV w/ 5 ms Response Time for $220
Dec 3, 2014, 10:32 PM
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
More Blog Posts
Copyright 2016 DailyTech LLC. -
Terms, Conditions & Privacy Information