Cancerous Tumors Detected, Controlled with Bioelectric Signals
February 7, 2013 6:29 AM
comment(s) - last by
A tumor (red) within a frog embryo
(Source: Brook Chernet; Tufts University School of Arts and Sciences)
It could be an early cancer indicator
Researchers have found a way to not only detect cancer through the use of bioelectric signals, but also
control the cancerous cells
A team of biologists from Tufts University School of Arts and Sciences, led by Brook Chernet, have used bioelectric signals to pinpoint cells that are likely to transform into tumors and even lowered the number of cases where cells turned cancerous.
Bioelectric signals are changes in electric currents created by the sum of electrical potential differences across a specialized tissue, cell system or organ. They regulate how cells behave, such as growing and multiplying.
Tufts scientists had previously shown that controlling membrane voltage can affect cell behavior such as proliferation and shape in vivo. They also found that this can induce the regenerative repair or even formation of whole organs.
In this study, the team encouraged tumor growth in frog embryos using messenger RNA (mRNA) that have human oncogenes Gli1, KrasG12D and Xrel3. The embryos experienced tumor growths like
, melanoma and lung cancer.
When using a membrane voltage-sensitive dye and fluorescence microscopy, the team found that the tumors had different depolarized membrane voltage compared to normal tissue. This allowed the researchers to identify tumors.
In addition, the team lowered the incidence of cancerous tumors. It did this by countering the tumor-inducing depolarization with an injection of mRNA containing certain ion channels into the cells. The embryos with oncogenes were injected with one of two ion channels: either GlyR-F99A or Kir4.1). These ion channels are proteins that control the passage of ions across cell membranes.
In both cases, the ion channels hyperpolarized membrane voltage gradients in the frog embryos and lowered the case of successive tumors.
This article is over a month old, voting and posting comments is disabled
RE: This is encouraging
2/7/2013 12:08:04 PM
Am i the only one who feels sad for the tadpoles?
"Game reviewers fought each other to write the most glowing coverage possible for the powerhouse Sony, MS systems. Reviewers flipped coins to see who would review the Nintendo Wii. The losers got stuck with the job." -- Andy Marken
Controlling Quadruple Helix DNA Could Prevent Some Cancers
January 23, 2013, 12:25 AM
New Treatment for Leukemia Saves Lives, One Step Closer to Market
December 14, 2012, 7:19 AM
Dow Chemical to NYC City Council: You Don't Even Know What Styrofoam is!
December 2, 2013, 8:30 PM
Retired Israel Air Force Commander: UAVs Need to Dogfight Before Replacing Fighter Pilots
November 27, 2013, 3:59 PM
Eating High-Fat Diet During Puberty May Increase Speed of Breast Cancer Development
November 27, 2013, 2:15 PM
Mayor Bloomberg Says No More Polystyrene Foam Dishes in NYC, Says it Can Cause Cancer
November 25, 2013, 11:51 AM
NASA Rejects Billionaire's Mission to Mars
November 22, 2013, 12:31 PM
Southwest Airlines Gives Passengers Wi-Fi Access from Gate to Gate
November 21, 2013, 12:15 PM
Most Popular Articles
NSA Snares Americans' Porn Viewing Histories in Effort to Target Muslims
December 1, 2013, 9:00 PM
Coalition of 20+ Tech Firms Backs MRAM as Potential DRAM, NAND Replacement
November 29, 2013, 11:59 PM
Fed Up With Cheating OEMs, Microsoft Trolls Chromebooks in New Ad
November 27, 2013, 4:09 PM
Xbox? PCs? Mobile? Microsoft Wants One Windows to Rule Them All
November 25, 2013, 8:21 PM
Seattle Restaurant Bans Google Glass, Tells Wearers to "Just shut up and get out"
November 27, 2013, 10:27 AM
Latest Blog Posts
Global Cyber Espionage Concerns Reveal Growing Cyber Armies
Nov 29, 2013, 11:04 AM
Is The Period Becoming an Expression of Anger?
Nov 26, 2013, 2:02 PM
NSA and Congress -- You Will Never Kill the Constitution, It's an Idea
Nov 10, 2013, 2:00 PM
AT&T Explores $100B+ USD Deal to Acquire Vodafone's European Operations
Nov 4, 2013, 7:34 AM
U.S. Army Developing Cyber, Electronic War Arsenal
Oct 31, 2013, 4:49 PM
More Blog Posts
Copyright 2013 DailyTech LLC. -
Terms, Conditions & Privacy Information