Cancerous Tumors Detected, Controlled with Bioelectric Signals
February 7, 2013 6:29 AM
comment(s) - last by
A tumor (red) within a frog embryo
(Source: Brook Chernet; Tufts University School of Arts and Sciences)
It could be an early cancer indicator
Researchers have found a way to not only detect cancer through the use of bioelectric signals, but also
control the cancerous cells
A team of biologists from Tufts University School of Arts and Sciences, led by Brook Chernet, have used bioelectric signals to pinpoint cells that are likely to transform into tumors and even lowered the number of cases where cells turned cancerous.
Bioelectric signals are changes in electric currents created by the sum of electrical potential differences across a specialized tissue, cell system or organ. They regulate how cells behave, such as growing and multiplying.
Tufts scientists had previously shown that controlling membrane voltage can affect cell behavior such as proliferation and shape in vivo. They also found that this can induce the regenerative repair or even formation of whole organs.
In this study, the team encouraged tumor growth in frog embryos using messenger RNA (mRNA) that have human oncogenes Gli1, KrasG12D and Xrel3. The embryos experienced tumor growths like
, melanoma and lung cancer.
When using a membrane voltage-sensitive dye and fluorescence microscopy, the team found that the tumors had different depolarized membrane voltage compared to normal tissue. This allowed the researchers to identify tumors.
In addition, the team lowered the incidence of cancerous tumors. It did this by countering the tumor-inducing depolarization with an injection of mRNA containing certain ion channels into the cells. The embryos with oncogenes were injected with one of two ion channels: either GlyR-F99A or Kir4.1). These ion channels are proteins that control the passage of ions across cell membranes.
In both cases, the ion channels hyperpolarized membrane voltage gradients in the frog embryos and lowered the case of successive tumors.
This article is over a month old, voting and posting comments is disabled
This is encouraging
2/7/2013 10:38:46 AM
It's always been difficult or next to impossible to identify cancerous cells so this could be a big breakthrough in not only cancer treatment but other diseases. Congrats on the good work.
RE: This is encouraging
2/7/2013 12:08:04 PM
Am i the only one who feels sad for the tadpoles?
"Well, there may be a reason why they call them 'Mac' trucks! Windows machines will not be trucks." -- Microsoft CEO Steve Ballmer
Controlling Quadruple Helix DNA Could Prevent Some Cancers
January 23, 2013, 12:25 AM
New Treatment for Leukemia Saves Lives, One Step Closer to Market
December 14, 2012, 7:19 AM
Nail Polish May Soon be Able to Detect Date Rape Drugs
August 26, 2014, 7:57 AM
SpaceX Falcon 9-R Rocket Suffers Malfunction, Self-Destructs During Test Flight
August 23, 2014, 9:36 AM
Texas Chosen as Site for SpaceX's First Commercial Launchpad
August 5, 2014, 1:44 PM
South Carolina Prison Finds Crashed Drone Carrying Drugs, Phones
August 1, 2014, 2:49 PM
NASA's Mars 2020 Rover Gains Seven New Instruments for Exploration
August 1, 2014, 1:30 PM
NASA Opportunity Rover Breaks Record for Most Miles Traveled on Another Planet
July 29, 2014, 1:38 PM
Most Popular Articles
Apple Announces 4.7" iPhone 6, 5.5" iPhone 6 Plus
September 9, 2014, 1:45 PM
Apple Announces Its Smartwatch: The $349 Apple Watch
September 9, 2014, 2:09 PM
Appalling Negligence: Decade-Old Windows XPe Holes Led to Home Depot Hack
September 8, 2014, 8:58 PM
T-Mobile Launches Un-carrier 7.0, Beefs Up Wi-Fi Calling
September 11, 2014, 2:56 PM
HTC Preps Nexus 9 With Nvidia K1 64-Bit "Denver" SoC, Android L Onboard
September 10, 2014, 10:21 PM
Latest Blog Posts
Space Terrorism is a Looming Threat For the United States
Apr 23, 2014, 7:47 PM
Facebook Aims to Provide Internet to "Every Person in the World" with Drones, Satellites
Apr 1, 2014, 10:20 AM
Retail Mobile Sites Experience Outages in Light of Simplexity's Bankruptcy
Mar 14, 2014, 8:48 AM
Tesla vs. BMW: Who Has the Safer EV?
Feb 1, 2014, 2:56 PM
Justice Leaks Details of Next HTC One Two Flagship Phone
Dec 5, 2013, 4:04 PM
More Blog Posts
Copyright 2014 DailyTech LLC. -
Terms, Conditions & Privacy Information