Cancerous Tumors Detected, Controlled with Bioelectric Signals
February 7, 2013 6:29 AM
comment(s) - last by
A tumor (red) within a frog embryo
(Source: Brook Chernet; Tufts University School of Arts and Sciences)
It could be an early cancer indicator
Researchers have found a way to not only detect cancer through the use of bioelectric signals, but also
control the cancerous cells
A team of biologists from Tufts University School of Arts and Sciences, led by Brook Chernet, have used bioelectric signals to pinpoint cells that are likely to transform into tumors and even lowered the number of cases where cells turned cancerous.
Bioelectric signals are changes in electric currents created by the sum of electrical potential differences across a specialized tissue, cell system or organ. They regulate how cells behave, such as growing and multiplying.
Tufts scientists had previously shown that controlling membrane voltage can affect cell behavior such as proliferation and shape in vivo. They also found that this can induce the regenerative repair or even formation of whole organs.
In this study, the team encouraged tumor growth in frog embryos using messenger RNA (mRNA) that have human oncogenes Gli1, KrasG12D and Xrel3. The embryos experienced tumor growths like
, melanoma and lung cancer.
When using a membrane voltage-sensitive dye and fluorescence microscopy, the team found that the tumors had different depolarized membrane voltage compared to normal tissue. This allowed the researchers to identify tumors.
In addition, the team lowered the incidence of cancerous tumors. It did this by countering the tumor-inducing depolarization with an injection of mRNA containing certain ion channels into the cells. The embryos with oncogenes were injected with one of two ion channels: either GlyR-F99A or Kir4.1). These ion channels are proteins that control the passage of ions across cell membranes.
In both cases, the ion channels hyperpolarized membrane voltage gradients in the frog embryos and lowered the case of successive tumors.
This article is over a month old, voting and posting comments is disabled
This is encouraging
2/7/2013 10:38:46 AM
It's always been difficult or next to impossible to identify cancerous cells so this could be a big breakthrough in not only cancer treatment but other diseases. Congrats on the good work.
RE: This is encouraging
2/7/2013 12:08:04 PM
Am i the only one who feels sad for the tadpoles?
"I want people to see my movies in the best formats possible. For [Paramount] to deny people who have Blu-ray sucks!" -- Movie Director Michael Bay
Controlling Quadruple Helix DNA Could Prevent Some Cancers
January 23, 2013, 12:25 AM
New Treatment for Leukemia Saves Lives, One Step Closer to Market
December 14, 2012, 7:19 AM
Creationists are Mad About Google Doodle Depicting Evolution
November 24, 2015, 8:48 PM
DHS and TSA: Whoops, We Missed That 73 Airport Employees May be Terrorists
November 19, 2015, 2:16 PM
Star Wars Spinoff Film "Rogue One", Theme Park Attractions Announced
August 17, 2015, 12:20 PM
SpaceX Falcon 9's Seventh Supply Mission to ISS Ends w/ Fiery Stage 1 Explosion
June 28, 2015, 1:10 PM
Cool Science Video: Glowing Millipede Prowls the Nevada Desert
May 18, 2015, 12:00 PM
Newly Discovered Costa Rican Glass Frog is Kermit's Doppelgänger
April 22, 2015, 11:26 AM
Latest Blog Posts
Sceptre Airs 27", 120 Hz. 1080p Monitor/HDTV w/ 5 ms Response Time for $220
Dec 3, 2014, 10:32 PM
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
More Blog Posts
Copyright 2016 DailyTech LLC. -
Terms, Conditions & Privacy Information