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Continual glucose monitor (left), pump worn on the belt that injects insulin under the patient’s skin (right), and a controller (a handheld smart phone)  (Source: Institut de recherches cliniques de Montreal)
Type 1 diabetics are expected to benefit from the new dual-hormone treatment

Being a type 1 diabetic is a full-time job, but a system that acts as an artificial pancreas could offer a bit of relief for those struggling to keep their glucose regulated.

An IRCM research team, led by Dr. Rémi Rabasa-Lhoret, have performed the first trial that compares an artifical pancreas system to a traditional diabetes treatment, and found that the artificial pancreas resulted in better glucose control.

The artificial pancreas is a dual-hormone system that delivers insulin and glucagon automatically through the use of a continuous glucose monitor (CGM) and advanced algorithm.

The algorithm obtains data from the CGM, and it calculates the amount of insulin required. It will also calculate the required glucagon, if needed. Insulin lowers blood sugar while glucagon raises it, preventing the diabetic from experiencing hypoglycemia. Hypoglycemia is the result of blood sugar dropping too low, and can result in confusion and even loss of consciousness.

Once the insulin and glucagon is calculated, the CGM sends it to the wireless pump, and it automatically administers the proper dose of the hormones.

While pumps are available to diabetics today, the sensors must be checked frequently and the pump's dosage must be adjusted. This new system does everything without any interference from the person wearing it.

"Approximately two-thirds of patients don't achieve their target range with current treatments," said Dr. Rabasa-Lhoret. "The artificial pancreas could help them reach these targets and reduce the risk of hypoglycemia, which is feared by most patients and remains the most common adverse effect of insulin therapy. In fact, nocturnal hypoglycemia is the main barrier to reaching glycemic targets."

In the study, 15 type 1 diabetic adults that used insulin pumps for at least three months prior to the study were sent to IRCM's facility for two, 15-hour visits. During the visits, their glucose levels were monitored as they exercised on a stationary bike. They were also given an evening meal and a snack, and were sent to bed.

It turns out that the addition of glucagon and the algorithm for calculated release helped participants avoid hypoglycemia during the night. In fact, those with the dual-hormone treatment had 15 percent better glucose control than those with conventional pump treatment.

In addition, the artificial pancreas had an 8-fold reduction in the risk of hypoglycemia, and a 20-fold reduction in the risk of hypoglycemia during the night.

Source: Science Daily

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Become a Diabetes Warrior
By Kurz on 1/31/2013 9:59:28 AM , Rating: 1
Cut the Carbs out of your diet, Bread, Cake,.
You don't need them to survive.

Read how to do it on this guys website.
He claims 0 Drugs 0 Insulin since 2009.

Only reason I know about this guy is because I was reading up on Cutting Carbs out of my diet to build muscle/cut off exess fat.

RE: Become a Diabetes Warrior
By TheDoc9 on 1/31/2013 11:14:54 AM , Rating: 2
This might work for type 2, but anyone with type 1 should stay away from miracle cures.

RE: Become a Diabetes Warrior
By Kurz on 1/31/2013 12:25:26 PM , Rating: 2
Isn't Type 1 the same?
Only difference instead of your body being insensitive to insulin, your pancreas just doesn't produce it since it gets destoryed.

By not taking in the carbs you are effectively reducing your need for insulin.

Btw it isn't a Cure, you are cutting out carbs and sugars reducing your need for insulin shots.

RE: Become a Diabetes Warrior
By GmTrix on 1/31/2013 4:08:10 PM , Rating: 2
Being resistant to insulin != Not having any. Don't try this as a type 1.

Source: I'm a type 1

RE: Become a Diabetes Warrior
By Kurz on 2/1/2013 6:42:22 AM , Rating: 2
Have you ever tried cutting Carbohydrates out of your diet completely?

You have to tools available to you to see how your blood sugar levels will react.

Why keep eating things your body can't process? And just stick with things your body can!

RE: Become a Diabetes Warrior
By Kurz on 2/1/2013 6:49:53 AM , Rating: 1
RE: Become a Diabetes Warrior
By cyberguyz on 1/31/2013 5:17:10 PM , Rating: 2
Oops! Forgot to charge my phone!

Seriously though assuming insulin resistance is all there is to Type 2 diabetes only tells us all that the person who said this seriously needs some education on the subject.

Type 2 is also a degenerative disease where a person's pancreas slowly reduces insulin production as they age and or the body slowly increases its demand to counter rising blood sugar levels. Yes of course resistance plays a part in this story, but it is a long way from being the cause and definition of Type 2 diabetes.

For those that are afflicted with from Type 1, this kind of contraption goes a long way toward helping these folks keep blood sugar within safe levels. These people will never be able to say goodbye to their meter and syringe/pen/pump, but this certainly helps -- as long as that smart phone's battery stays charged ;)

RE: Become a Diabetes Warrior
By Kurz on 2/1/2013 6:44:31 AM , Rating: 1
Yes... I understand that but this all stems from the fact you ingest Carbohydrates. So why keep ingesting something that your body can't process?

There two other groups of energy you can ingest.
Fats and Proteins, both of which are completely viable.

RE: Become a Diabetes Warrior
By leslie1234 on 2/1/2013 12:32:40 PM , Rating: 3
It's nice of you to give a suggestion, but it wouldn't work. Type 1s need insulin whether they eat anything or not because your liver produces glucose all day long. This is the "basal" part of every T1's daily insulin regimen. And, a significant portion of fats and proteins consumed gets converted into glucose in the body, so T1's would still need insulin for food too. For example, if my T1 son ate a big hunk of cheese, his blood sugar would rise slowly but steadily for several hours without insulin. Misinformation hurts T1s because it makes people believe there's an easy fix, so why be sympathetic, fund research, provide necessary support at school, etc.

By BugblatterIII on 1/30/2013 9:20:51 PM , Rating: 5
My cousin's young daughter has type 1 diabetes and it dominates the lives of her and her parents. They also can't rely on teachers to properly take care of her during school. This would change their lives overnight.

Hopefully much of the device will be implantable ultimately, but even a backpack would be an improvement.

By scbundy on 1/31/2013 12:53:50 AM , Rating: 5
My son is a type 1 diabetic, he's 7 years old and been on a pump for about a year. The pump was a huge improvement over injections, both in keeping his levels tighter and having a more normal lifestyle. Have you ever tried telling a 5 year old that he can't have a piece of cake at a birthday party and instead has to have a carb free piece you made at home the night before? It'll break your heart.

However this sounds fantastic, once it's been perfected. The pump is already great, but it's a lot of effort. We're constantly poking his fingers and checking his levels and making adjustments. Waking up at 3am b/c we didn't like the number we saw a few hours earlier.

I can only hope that when my son is my age, he can go out with his friends for pizza and wings, have a drink and watch the hockey game and not have to sneak away every 30 minutes to the bathroom to poke his finger and get a reading.

Knew it was coming...
By Ytsejamer1 on 1/31/2013 7:07:21 AM , Rating: 2
I've been a diabetic for about uggghh, 20 years. I've been on a wireless insulin pump (Insulet Corps Omnipod) system since 2006. It's been fantastic. I'm not super active, but I didn't want wires hanging out and possibly being grabbed by something if I'm working in a server cabinet or whatever.

A couple of years ago, the specialist recommended a continuous blood sugar monitor...I always thought it was just a matter of time before someone put both pump and continuous monitor together in a package.

The pump has made my life MUCH MUCH easier and while there are considerations to be mindful of when you're wearing them, they are a godsend for keeping numbers more in line with where they need to be. With diabetes causing many health issues in the longterm, having tighter control from the outset almost alleviates all of them. Kudos for the ongoing research for a system like this.

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