MPL Vaccine Could Treat, Prevent Alzheimer's Disease in Humans
January 16, 2013 10:32 AM
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The weekly injection removed 80 percent of senile plaques that cause Alzheimer's
Canadian researchers have come one giant step closer to finding treatment for those with
, and even a preventative vaccine.
The team of researchers hail from Université Laval, CHU de Québec, and pharmaceutical firm GlaxoSmithKline (GSK), and was led by Dr. Serge Rivest, professor at Université Laval's Faculty of Medicine and researcher at the CHU de Québec research center.
A key part of Alzheimer's disease is the production of a toxic molecule called amyloid beta. The body's defenders, called microglial cells, cannot eliminate amyloid beta, and that's when senile plaques are formed.
But the new study gives the brain's immune cells a boost through monophosphoryl lipid A, called MPL, which is a vaccine that has already been proven safe through its use with GSK.
After giving mice with Alzheimer's symptoms weekly injections of MPL for 12 weeks, about 80 percent of senile plaques were eliminated. Also, the mice showed improvement in cognitive function.
According to the team, the MPL injection could not only slow the progression of the disease in patients already showing symptoms, but also be used as a preventative vaccine for those at risk.
Last September, the cancer drugs
erlotinib (Tarceva) and gefitinib (Iressa) were used to
cure Alzheimer's in fruit flies and rats
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RE: Sign Me Up!
1/16/2013 1:22:54 PM
Yeah, this is really awesome. Seems too good to be true.
I'm worried too, as I've always been forgetful...
Would be AMAAAAAZING if we could cure and treat this!
RE: Sign Me Up!
1/16/2013 1:43:58 PM
Everyone is forgetful, not everyone have or would ever have an Alzheimer's. Our memory is structured in a way that most of information we process never gets into permanent memory, it sort of being cached for a while and then flushed when new information needs to get processed. Plus, our memory is mostly associative, i.e. you would never remember what you did on January 13th 5 years ago, but when you meet your friend or go to a park, you would remember fleshes of similar events that very well may have happened on that particular day. The drawback of associative memory is that without a proper reference point (or an association) information seems to be lost or forgotten.
RE: Sign Me Up!
1/16/2013 2:17:18 PM
Remember how I took that home wine making course and forgot how to drive?
"The Space Elevator will be built about 50 years after everyone stops laughing" -- Sir Arthur C. Clarke
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