MPL Vaccine Could Treat, Prevent Alzheimer's Disease in Humans
January 16, 2013 10:32 AM
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The weekly injection removed 80 percent of senile plaques that cause Alzheimer's
Canadian researchers have come one giant step closer to finding treatment for those with
, and even a preventative vaccine.
The team of researchers hail from Université Laval, CHU de Québec, and pharmaceutical firm GlaxoSmithKline (GSK), and was led by Dr. Serge Rivest, professor at Université Laval's Faculty of Medicine and researcher at the CHU de Québec research center.
A key part of Alzheimer's disease is the production of a toxic molecule called amyloid beta. The body's defenders, called microglial cells, cannot eliminate amyloid beta, and that's when senile plaques are formed.
But the new study gives the brain's immune cells a boost through monophosphoryl lipid A, called MPL, which is a vaccine that has already been proven safe through its use with GSK.
After giving mice with Alzheimer's symptoms weekly injections of MPL for 12 weeks, about 80 percent of senile plaques were eliminated. Also, the mice showed improvement in cognitive function.
According to the team, the MPL injection could not only slow the progression of the disease in patients already showing symptoms, but also be used as a preventative vaccine for those at risk.
Last September, the cancer drugs
erlotinib (Tarceva) and gefitinib (Iressa) were used to
cure Alzheimer's in fruit flies and rats
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RE: Sign Me Up!
1/16/2013 11:57:55 AM
fair enough...i thought it was funny when I heard it. Oh well.
RE: Sign Me Up!
1/16/2013 12:12:40 PM
I try to put a good spin on it, too. Instead of Easter Eggs, I just tell myself it'll let me save money on books. I can keep re-reading the ones I have instead of buying new ones.
Recently, I re-read a book that I KNOW I've read before. I remembered not one word, not one event, not one plotline (not one jot or tittle) in the whole thing. That's scary.
RE: Sign Me Up!
1/16/2013 12:50:13 PM
Hell it is. This is the most scary thing for me, that one day, I watch my son directly to his eyes and not know who he is or why he is worried.
We humans are all about our minds, if we lose it in a way that you forget everything (the good things and the bad things) then there is no point in living anymore, at least that my opinion. I'd rather die than forget.
I'll be following this "vaccine" close, when it is available, I will take it undoubtedly.
“Then they pop up and say ‘Hello, surprise! Give us your money or we will shut you down!' Screw them. Seriously, screw them. You can quote me on that.” -- Newegg Chief Legal Officer Lee Cheng referencing patent trolls
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