Embryonic Stem Cells Make Damaged Artery Functional Again
January 13, 2013 1:45 PM
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Embryonic stem cells from baboons produced a fully functional artery
Texas scientists have used embryonic stem cells to heal a severely damaged
in a baboon.
A team from the Texas Biomedical Research Institute in San Antonio, led by John L. VandeBerg, Ph.D., took embryonic stem cells from baboons to produce a fully functional artery.
To do this, the team extracted cells that line the surface of a part of an artery and
replaced them with cells
that were derived from embryonic stem cells. Both ends of the arterial segment were then connected to plastic tubing inside a bioreactor, which encourages cells to grow.
Fluid was then pumped through the artery under pressure to mimic blood, and a different fluid was then used to soak the outside of the artery. Only three days later, the inner surface began to regenerate, and after two weeks, the inside of the artery was completely restored to a functional state.
The team even stripped another artery without placing the stem cells inside to see if it was the stem cells that did the rejuvenating. The artery without
the stem cells
didn't heal and never became functional.
"We first cultured the stem cells in petri dishes under special conditions to make them differentiate into cells that are the precursors of blood vessels, and we saw that we could get them to form tubular and branching structures, similar to blood vessels," said VandeBerg. "Just think of what this kind of treatment would mean to a patient who had just suffered a heart attack as a consequence of a damaged coronary artery. And this is the real potential of stem cell regenerative medicine -- that is, a treatment with stem cells that regenerates a damaged or destroyed tissue or organ."
This study appeared in the
Journal of Cellular and Molecular Medicine
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RE: Basic maintenance.
1/15/2013 8:44:05 AM
"Ok, so tell me, how is an ordinary person supposed to conduct a 5 year scientific trial that meets your expectations? It just won't happen. The nearest I can do is a one person trial, which is exactly what I am doing, and what those other people are doing."
of course, an individual with no medical training, no funding and no trial support cannot produce high quality scientific research.
thats why we have research departments in all major universities.
the individual cannot be expected to widely read the literature and produce their own considered opinion - this is why we have systematic reviews and metaanalyses.
the individual cannot even really be expected to read and understand the results of systematic reviews - this is why we have doctors - you pay them to do this work for you and you have to trust them to give you the best most honest advice.
if you dont have this sense of trust with your current doctor then i suggest you try to find another one. looking around trying to figure everything out yourself is frustrating and has a risk of causing harm (like steve jobs).
im not a specialist researcher in mesenchymal stem cells but i do know that there is a lot of FUD about stem cell research.
stem cells != embryonic stem cells
mesenchymal stem cells can be harvested from lots of different tissues - nothing has to die to produce them. there was an outcry about taking stem cells from embryos (which is very understandable) - however the overwhelming majority of stem cell research today does not involve any embryos. stem cells have been used for decades - e.g. a bone marrow transplant - a very common and old treatment for some cancers is essentially a transplant of multipotent stem cells.
with regard to eating a normal amount of a varied healthy diet, not smoking, not drinking too much and exercising regularly - this is common sense. you don't a doctor or anyone else to tell you that these are good things to do.
stem cell research (and by extension other research) is not being done so that we can live forever whilst chain smoking whilst guzzling down bucket after bucket of kfc.
its not an either/or situation. we should live nice clean healthy lifestyles and if research on top of that can produce treatments to further improve our quality of life then that can only be a good thing.
"A politician stumbles over himself... Then they pick it out. They edit it. He runs the clip, and then he makes a funny face, and the whole audience has a Pavlovian response." -- Joe Scarborough on John Stewart over Jim Cramer
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