Stem Cell Transplant Treats Retinitis Pigmentosa in Mice, Restores Sight
January 8, 2013 10:06 AM
Developing cells were transplanted into the eyes of blind mice, ultimately allowing them to see again
Oxford University scientists have found a valid treatment for retinitis pigmentosa through stem cells and
The study, led by Professor Robert MacLaren in the Nuffield Department of Clinical Neurosciences at the University of Oxford, transplanted developing cells into the eyes of blind mice, ultimately allowing them to see again.
Using mice that had a complete loss of photoreceptor cells in their retinas, which allows them to sense light, the researchers transplanted developing stem cells into their eyes. After two weeks, the cells recreated a full light-detecting layer on the retina.
To test whether the
mice could actually see
, the researchers performed a pupil constriction test. Ten out of the 12 mice responded to the light and ran away to the dark, showing that their retinas were sensing light and this reaction was transmitted down the optic nerve to the brain.
"Stem cells have been trialled in patients to replace the pigmented lining of the retina, but this new research shows that the light-sensing layer might also be replaced in a similar way," said MacLaren. "The light-sensing cells have a highly complex structure and we observed that they can resume function as a layer and restore connections after transplantation into the completely blind retina.
"We have shown the transplanted cells survive, they become light-sensitive, and they connect and reform the wiring to the rest of the retina to restore vision. The ability to reconstruct the entire light sensitive layer of the retina using cell transplantation is the ultimate goal of the stem cell treatments for blindness we are all working towards."
This study was published in
Proceedings of the National Academy of Sciences
"A lot of people pay zero for the cellphone ... That's what it's worth." -- Apple Chief Operating Officer Timothy Cook
"AAQ" Chemical Temporarily Lets Blind Mice See
July 30, 2012, 9:09 AM
PIQ ROBOTTM reveals its new artificial intelligence software
November 29, 2016, 12:59 AM
One more time - Happy Thanksgiving to Everyone Around the World
November 24, 2016, 4:00 AM
Google’s Smart Contact Lens Project gets halted for 2016
November 20, 2016, 7:00 AM
Cell Research Study shows African Americans have greater immune response to infection
November 10, 2016, 1:00 AM
UTHealth Clinical Trial Shows Progress Using Stem Cells to Treat Traumatic Brain Injury
November 8, 2016, 1:00 AM
Uber Partners with Circulation to Pilot Program Connecting Transportation and Digital Health Care
November 6, 2016, 5:00 AM
Most Popular Articles
What Can You Do with Your New Echo Dot?
December 3, 2016, 5:00 AM
Google has developed Deep Learning Algorithm to detect Diabetic Eye Disease
December 4, 2016, 5:00 AM
Sound Blaster Z SBX PCIE Gaming Sound Card - Superb High Performance Sound Card
December 6, 2016, 1:00 AM
GizmoTab – Verizon’s new $80 Tablet for Kids
December 4, 2016, 5:30 AM
Foscam R2 Home Security Camera System – High Quality High FHD Security Video Footage with No Monthly Fees
December 1, 2016, 2:00 AM
Latest Blog Posts
What's in the News?
Dec 11, 2016, 5:00 AM
Dec 10, 2016, 5:00 AM
Dec 9, 2016, 5:00 AM
Latest Tech News
Dec 8, 2016, 5:11 AM
In The News
Dec 7, 2016, 5:00 AM
e Guide: Mobile Security for 2017
Dec 6, 2016, 5:00 AM
Apple Car is Not Dead
Dec 5, 2016, 1:00 AM
Dec 4, 2016, 5:00 AM
Dec 3, 2016, 5:00 AM
Dec 2, 2016, 5:00 AM
Surface Ergonomic Keyboard
Dec 1, 2016, 3:01 AM
Chapeconense plane crash: Football rallies around Brazilian Team
Nov 30, 2016, 1:00 AM
How to Extends Your iPhone’s Battery Life
Nov 29, 2016, 12:49 AM
Nov 28, 2016, 1:12 AM
News: Fidel Castro
Nov 27, 2016, 5:00 AM
Nov 26, 2016, 5:00 AM
Changes in Social status affect the way genes turn on and off within immune cells.
Nov 25, 2016, 5:12 AM
Austrian far–right hopeful Hofer may back EU vote.
Nov 24, 2016, 4:00 AM
Final Fantasy XV Leaked Before Nov 29 Launch Date
Nov 23, 2016, 1:00 AM
More Blog Posts
Copyright 2016 DailyTech LLC. -
Terms, Conditions & Privacy Information