Immune Cells Reprogrammed to Fight Cancer, Infection
January 4, 2013 7:40 PM
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Tests showed that the new T-cells had unlimited lifespans and longer telomeres, which are caps on the ends of their chromosomes that protect them from aging
Scientists have found a way to
so they can fight infections and cancer better than normal immune cells.
Dr. Hiromitsu Nakauchi and a team of researchers from the University of Tokyo have given the T-cells of patients with HIV and cancer longer lifespans, which allows them to fight cancer and infections more effectively.
Our bodies have immune cells that are supposed to fight off infection and cancer, but due to their short lifespans and low numbers, they are not always able to stand up to such infections and diseases.
The researchers took the T-cells from a patient with HIV and another with malignant melanoma. The mature immune T-cells were turned into induced pluripotent stem cells (iPSCs), which have the ability to differentiate into any cell type. From there, the iPSCs were redifferentiated into T-cells, but had
longer lifespans and greater growth
Tests showed that the new T-cells had unlimited lifespans and longer telomeres, which are caps on the ends of their chromosomes that protect them from aging. The T-cells recognized the protein MART-1, which is commonly found on melanoma tumors.
Now the team is working on testing whether the cells can fight infection without harming healthy cells.
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RE: Bring it on!
1/10/2013 2:39:42 PM
Why do I have to be close to death to understand that sometimes you really want to live and sometimes you don't? Do you want me to tell stories of the family I have watched wither and die to untreatable and agressive cancer or other unknown wasteing illneses doctors failed to treat?
My point is we must be very carefull when we are desperate as there are people who will prey on you. Just do some reading on all the crazy stuff even very smart people try when they are desperate (*cough* Steve Jobs *cough*), or what some parents of children with autism have done to their kids to try and "help" them.
I'm fine with people having access to any experimental medicine they can afford so long as it is done with full disclosure and supervision. I personally would just want anything done be well documented and results published so all can benifit. I would also like to point out that most legitimate researchers would likely turn you down anyway unless they are sure the "risks" are managable or you are exactly the right kind of subject they are looking for.
“Then they pop up and say ‘Hello, surprise! Give us your money or we will shut you down!' Screw them. Seriously, screw them. You can quote me on that.” -- Newegg Chief Legal Officer Lee Cheng referencing patent trolls
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