Immune Cells Reprogrammed to Fight Cancer, Infection
January 4, 2013 7:40 PM
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Tests showed that the new T-cells had unlimited lifespans and longer telomeres, which are caps on the ends of their chromosomes that protect them from aging
Scientists have found a way to
so they can fight infections and cancer better than normal immune cells.
Dr. Hiromitsu Nakauchi and a team of researchers from the University of Tokyo have given the T-cells of patients with HIV and cancer longer lifespans, which allows them to fight cancer and infections more effectively.
Our bodies have immune cells that are supposed to fight off infection and cancer, but due to their short lifespans and low numbers, they are not always able to stand up to such infections and diseases.
The researchers took the T-cells from a patient with HIV and another with malignant melanoma. The mature immune T-cells were turned into induced pluripotent stem cells (iPSCs), which have the ability to differentiate into any cell type. From there, the iPSCs were redifferentiated into T-cells, but had
longer lifespans and greater growth
Tests showed that the new T-cells had unlimited lifespans and longer telomeres, which are caps on the ends of their chromosomes that protect them from aging. The T-cells recognized the protein MART-1, which is commonly found on melanoma tumors.
Now the team is working on testing whether the cells can fight infection without harming healthy cells.
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RE: Bring it on!
1/7/2013 4:20:28 PM
Who are you to make that choice for them? It is their body, their life, their risk.
I say give them the choice to make, not you.
Have you ever stared at death with your eye? Have you looked it in the face knowing you might die soon?
Don't talk about things being "ethical" or "false hope" until you have.
People who are terminal are perfect subjects for radical and experimental treatments. Many of them would give anything to have a chance at living longer--knowing that it might not do them any good, or make things "worse." I know plenty that have faced situations like this. Some of them are alive to this day due to last minute experimental treatments.
We don't need a nanny or some Government agent telling us what we should and should not do in dire situations like this.
RE: Bring it on!
1/9/2013 2:31:14 PM
EXACTLY, it is one person's choice to do untested cancer treatment, have doctor-assisted suicide, allow their baby fetus to be harvested for stem cells, or to have an abortion.
No government should be telling anybody otherwise, thank you MrBlastman for your insightful arguements
RE: Bring it on!
1/10/2013 2:39:42 PM
Why do I have to be close to death to understand that sometimes you really want to live and sometimes you don't? Do you want me to tell stories of the family I have watched wither and die to untreatable and agressive cancer or other unknown wasteing illneses doctors failed to treat?
My point is we must be very carefull when we are desperate as there are people who will prey on you. Just do some reading on all the crazy stuff even very smart people try when they are desperate (*cough* Steve Jobs *cough*), or what some parents of children with autism have done to their kids to try and "help" them.
I'm fine with people having access to any experimental medicine they can afford so long as it is done with full disclosure and supervision. I personally would just want anything done be well documented and results published so all can benifit. I would also like to point out that most legitimate researchers would likely turn you down anyway unless they are sure the "risks" are managable or you are exactly the right kind of subject they are looking for.
"Game reviewers fought each other to write the most glowing coverage possible for the powerhouse Sony, MS systems. Reviewers flipped coins to see who would review the Nintendo Wii. The losers got stuck with the job." -- Andy Marken
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