Peptide-Coated Nanoparticles Offer Early Cancer Detection in Urine
December 19, 2012 8:35 AM
comment(s) - last by
(Source: New Line Cinema)
The particles (brown) are coated with peptides (blue) that are cleaved by enzymes (green) found at the disease site
(Source: Justin H. Lo)
The method amplifies biomarker detection in urine
MIT researchers may have found a new way of amplifying cancer biomarkers earlier through
a patient's urine
The MIT research team, led by Sangeeta Bhatia, has used altered nanoparticles to make the proteins produced by cancerous cells easy to recognize in urine. This could pave the way for earlier detection as well as treatment.
The problem is that cancer cells only create a small amount of these proteins, and they are often too diluted for detection.
This is how it works: nanoparticles are coated in peptides, allowing them to express 10 different peptides. Each peptide is a different size, making them easily seen once they finally exit through the urine.
The peptide-coated nanoparticles interact with proteases within the body, which are enzymes that cleave proteins into tiny pieces. Cancer cells are known to create an abundance of proteases called MMPs, which help the cancer cells move around and spread by cutting through proteins.
The MMPs target the peptide coating on the nanoparticles because peptides are short protein fragments. The nanoparticles then group at
the tumor site
and push their way through the leaky blood vessels that surround it.
Once the proteases cleave the peptides around the nanoparticles, the peptides are released into the bloodstream and group together in the kidneys. From there, they are released into the patient's urine and are easily seen using mass spectrometry.
This method has already been tested on mice with early stages of colorectal cancer. It accurately showed the early formation of tumors.
Bhatia believes this could one day
diagnose cancer earlier
than possible today, helping to improve the chances of survival.
This article is over a month old, voting and posting comments is disabled
RE: Amazing Research
12/19/2012 4:20:04 PM
There's no such thing as a cure for cancer. You can only take preventative measures against it, treat it, or surgically remove it.
"Let's face it, we're not changing the world. We're building a product that helps people buy more crap - and watch porn." -- Seagate CEO Bill Watkins
Chinese Scientists Produce Neurons from Urine
December 11, 2012, 11:29 PM
New Bra Continuously Checks Breasts for Tumors
October 11, 2012, 9:59 PM
Prostate Cancer Cured in Mice with Human Vaccine
June 20, 2011, 7:48 PM
Microsoft Co-founder Paul Allen Donates $100M to Fight Raging Ebola Epidemic
October 23, 2014, 6:05 PM
Cool Science Video of the Day: Carnivorous Leech Eats Giant Jungle Worm
October 16, 2014, 6:44 PM
Facebook CEO and Founder, Mark Zuckerberg, Donates $25M to Fight Ebola
October 14, 2014, 5:06 PM
Chagrined Over Leaks, CDC Confirms First U.S. Ebola Diagnosis in Dallas, Texas
September 30, 2014, 5:55 PM
Nail Polish May Soon be Able to Detect Date Rape Drugs
August 26, 2014, 7:57 AM
SpaceX Falcon 9-R Rocket Suffers Malfunction, Self-Destructs During Test Flight
August 23, 2014, 9:36 AM
Most Popular Articles
Amid Theater Boycott Netflix Defiantly Plans New Movies, Plus 3 TV Shows for 2015
October 24, 2014, 7:30 PM
AT&T Defeats Purpose of New Apple SIM, Locks iPad Air 2 SIMs to Its Network
October 24, 2014, 2:17 PM
CVS, Rite Aid Kill Unofficial Apple Pay Support, Burn Google Wallet Users in the Process
October 25, 2014, 5:26 PM
1 Million Credit Card Activated on Apple Pay Within 72 Hours, Walmart CEO Hopes Visa "Suffers"
October 28, 2014, 8:17 AM
Microsoft's Figures Show Desktop Users Flocking to Windows 10 Preview
October 27, 2014, 11:04 AM
Latest Blog Posts
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
Space Terrorism is a Looming Threat For the United States
Apr 23, 2014, 7:47 PM
More Blog Posts
Copyright 2014 DailyTech LLC. -
Terms, Conditions & Privacy Information