Peptide-Coated Nanoparticles Offer Early Cancer Detection in Urine
December 19, 2012 8:35 AM
comment(s) - last by
(Source: New Line Cinema)
The particles (brown) are coated with peptides (blue) that are cleaved by enzymes (green) found at the disease site
(Source: Justin H. Lo)
The method amplifies biomarker detection in urine
MIT researchers may have found a new way of amplifying cancer biomarkers earlier through
a patient's urine
The MIT research team, led by Sangeeta Bhatia, has used altered nanoparticles to make the proteins produced by cancerous cells easy to recognize in urine. This could pave the way for earlier detection as well as treatment.
The problem is that cancer cells only create a small amount of these proteins, and they are often too diluted for detection.
This is how it works: nanoparticles are coated in peptides, allowing them to express 10 different peptides. Each peptide is a different size, making them easily seen once they finally exit through the urine.
The peptide-coated nanoparticles interact with proteases within the body, which are enzymes that cleave proteins into tiny pieces. Cancer cells are known to create an abundance of proteases called MMPs, which help the cancer cells move around and spread by cutting through proteins.
The MMPs target the peptide coating on the nanoparticles because peptides are short protein fragments. The nanoparticles then group at
the tumor site
and push their way through the leaky blood vessels that surround it.
Once the proteases cleave the peptides around the nanoparticles, the peptides are released into the bloodstream and group together in the kidneys. From there, they are released into the patient's urine and are easily seen using mass spectrometry.
This method has already been tested on mice with early stages of colorectal cancer. It accurately showed the early formation of tumors.
Bhatia believes this could one day
diagnose cancer earlier
than possible today, helping to improve the chances of survival.
This article is over a month old, voting and posting comments is disabled
RE: Amazing Research
12/19/2012 11:55:31 AM
Treatments and "cures" are basically the same thing. the only difference is efficacy. If the drug companies actually had a cure for cancer you had better believe they would be selling it, for a ton of money, but they would be selling it.
"Game reviewers fought each other to write the most glowing coverage possible for the powerhouse Sony, MS systems. Reviewers flipped coins to see who would review the Nintendo Wii. The losers got stuck with the job." -- Andy Marken
Chinese Scientists Produce Neurons from Urine
December 11, 2012, 11:29 PM
New Bra Continuously Checks Breasts for Tumors
October 11, 2012, 9:59 PM
Prostate Cancer Cured in Mice with Human Vaccine
June 20, 2011, 7:48 PM
SpaceX Falcon 9-R Rocket Suffers Malfunction, Self-Destructs During Test Flight
August 23, 2014, 9:36 AM
Texas Chosen as Site for SpaceX's First Commercial Launchpad
August 5, 2014, 1:44 PM
South Carolina Prison Finds Crashed Drone Carrying Drugs, Phones
August 1, 2014, 2:49 PM
NASA's Mars 2020 Rover Gains Seven New Instruments for Exploration
August 1, 2014, 1:30 PM
NASA Opportunity Rover Breaks Record for Most Miles Traveled on Another Planet
July 29, 2014, 1:38 PM
Commercial Drones to Get Privacy Guidelines Via Executive Order
July 25, 2014, 5:34 PM
Most Popular Articles
Apple Scores Patents, Preps New Reversible USB Plug for iPhone 6 Connector
August 18, 2014, 1:32 PM
New AMD Fusion-Based Laptop From HP to Pack a Punch at $199
August 18, 2014, 4:13 PM
BlackBerry Reinvents Itself, Prepares for Potential Smartphone-Free Future
August 18, 2014, 7:51 PM
New Photos Show “Assembled” iPhone 6, Protruding Camera Ring
August 20, 2014, 2:32 PM
Lumia 830 Gets Major Upgrades Including New 20.1 Megapixel Toshiba Sensor
August 15, 2014, 6:00 PM
Latest Blog Posts
Space Terrorism is a Looming Threat For the United States
Apr 23, 2014, 7:47 PM
Facebook Aims to Provide Internet to "Every Person in the World" with Drones, Satellites
Apr 1, 2014, 10:20 AM
Retail Mobile Sites Experience Outages in Light of Simplexity's Bankruptcy
Mar 14, 2014, 8:48 AM
Tesla vs. BMW: Who Has the Safer EV?
Feb 1, 2014, 2:56 PM
Justice Leaks Details of Next HTC One Two Flagship Phone
Dec 5, 2013, 4:04 PM
More Blog Posts
Copyright 2014 DailyTech LLC. -
Terms, Conditions & Privacy Information