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Researchers found a way to turn old, aging stem cells into young, functional versions for cardiac tissue

A team of Canadian researchers have found a way to make old stem cells feel young again, which could be beneficial for elderly patients with heart conditions
 
The research team, which consists of Milica Radisic and Dr. Ren-Ke Li from the Institute of Biomaterials and Biomedical Engineering (IBBME), has created a "fountain of youth" for aging stem cells, which allows them to be young and functional again.
 
The team specifically targeted cardiac tissue. The problem with some stem cell therapies is that the body can reject them. But researchers started using the patient's own stem cells in order to avoid rejection, yet there was still another problem -- elderly patients with aging stem cells tend to not function as well as younger stem cells, meaning they won't be as helpful in patching up cardiac tissue that has been damaged. 
 
But the new technique involves placing elderly stem cells in a micro-environment, where they are mixed with different growth factors that lead to blood vessel growth and cell proliferation. These growth factors ended up stimulating the old stem cells, and turned off certain aging factors. Using two specific molecules, called p16 and RGN, turned the cells to a much younger state. 
 
This will allow researchers to grow cardiac patches for damaged hearts without worrying about rejection or loss of function. 

Source: Eurekalert



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RE: minor corrections
By patronanejo on 12/5/2012 2:59:50 PM , Rating: 1
@EricMartello:

You don't know shit about this. You look like an asshat when you lay into somebody without at least checking a couple of things.
quote:
What's your point? Genes are molecules and paraphrasing wikipedia makes you look like a tool.
His point is that the article confuses growth factors with senescence markers. Regucalcin and p16 are not used to turn cardiac tissue to a much younger state. Two proangiogenic cytokines--vascular endothelial growth factor (VEGF)and basic fibroblast growth factor (bFGF) are the two "specific molecules" used to perform that function--exactly as bioorganic says.
quote:
No, it's not worth noting that because the experiment was testing the cells themselves
Wrong again . The restored cells were used to construct SVR (surgical ventricular reconstruction) patches, and the positive results of this study are interpreted from the results of SVR performed on rats using these patches.

Because this study is relevant to a lay audience only because of its implications on clinical treatment, it most certainly is relevant that these results have yet been observed in humans.
quote:
In the second paragraph you reveal yourself to be a libtard, claiming my rebuttal to his post is an "attack". Obama much?
Typical underinformed hubris from the science-phobic Fox News crowd. Not that your spectacular ignorance could make the right wing look much dumber.


RE: minor corrections
By patronanejo on 12/5/2012 3:02:43 PM , Rating: 2
J Am Coll Cardiol. November 20, 2012,60( 21 ):2237-2249 doi:10.1016/j.jacc.2012.08.985


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