New Master Control Gene Method Could Regulate Human Blood Stem Cells
November 12, 2012 9:44 AM
comment(s) - last by
The researchers have expanded the stem cells while keeping their identity intact
A team of Canadian scientists has found a master control gene for stem cells that can be controlled and used for clinical use.
Dr. Eric Lechman, study leader from Ontario Cancer Institute (OCI), along with Dr. John Dick, a Senior Scientist at University Health Network's McEwen Centre for Regenerative Medicine and OCI, have discovered the master control gene for
This new master control gene could act as a way of regulating human blood stem cells. According to Lechman, they removed a master control gene (microRNA 126) that oversees and controls the expression of hundreds of other genes by silencing them. By silencing them, they are unable to divide.
In the study, excess numbers of microRNA 126 binding sites were added
to the stem cells
using a viral vector, and the virus absorbed specific microRNA 126 in the cells. This made other genes, which are normally silenced, become conspicuous. From there, long-term expansion of the blood stem cells was possible "without exhaustion or malignant transformation."
"For the first time in human blood stem cells, we have established that a new class of non-coding RNA called miRNA represents a new tactic for manipulating these cells, which opens the door to expanding them for therapeutic uses," said Dick.
This article is over a month old, voting and posting comments is disabled
Dr. Eric Lechman
11/12/2012 12:41:20 PM
So Dr Lechman was examining and otherwise toying around with blood... why am I not surprised... Cool research though I hope that they can find a safe and beneficial application for this.
Though I still smell a vampire plot....
RE: Dr. Eric Lechman
11/12/2012 1:40:21 PM
or Viral Zombie Apocalypse i think this research is great but risky.
RE: Dr. Eric Lechman
11/12/2012 2:43:36 PM
Maybe they can fill the blood with stem cells causing vampiric-style immortality as they are delivered to all parts of the body where blood flows?
"We’re Apple. We don’t wear suits. We don’t even own suits." -- Apple CEO Steve Jobs
UCSD is "Printing" Blood Vessels in Seconds
September 14, 2012, 1:43 PM
RNP Platform: Ban Marijuana, Embryonic Stem Cells, Morning After Pill
September 2, 2012, 3:48 PM
Creationists are Mad About Google Doodle Depicting Evolution
November 24, 2015, 8:48 PM
DHS and TSA: Whoops, We Missed That 73 Airport Employees May be Terrorists
November 19, 2015, 2:16 PM
Star Wars Spinoff Film "Rogue One", Theme Park Attractions Announced
August 17, 2015, 12:20 PM
SpaceX Falcon 9's Seventh Supply Mission to ISS Ends w/ Fiery Stage 1 Explosion
June 28, 2015, 1:10 PM
Cool Science Video: Glowing Millipede Prowls the Nevada Desert
May 18, 2015, 12:00 PM
Newly Discovered Costa Rican Glass Frog is Kermit's Doppelgänger
April 22, 2015, 11:26 AM
Latest Blog Posts
Sceptre Airs 27", 120 Hz. 1080p Monitor/HDTV w/ 5 ms Response Time for $220
Dec 3, 2014, 10:32 PM
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
More Blog Posts
Copyright 2016 DailyTech LLC. -
Terms, Conditions & Privacy Information