UCSD is "Printing" Blood Vessels in Seconds
September 14, 2012 1:43 PM
It's alive! Breakthrough holds great promise for tissue engineering
One of the remarkable things about stem cells is that when placed in their typical environment -- in terms of shape, mechanical forces, and chemical signals -- they
tend to differentiate into the desired tissue type
The difficulty is creating the proper environment.
Among the most daunting tasks of tissue engineering is growing blood vessels. In order to create functional organs, a tissue engineer must intubate the growing target tissue
with blood vessels
. But creating the proper 3D structure to coax stem cells into differentiating into the correct kinds of endothelial and muscular cells to form the blood vessels has been a daunting task. So far most efforts using techniques like micro-contact printing and photolithography have only been able to create crude 2D structures.
But researchers at the
University of California, San Diego
a top player
in the field of tissue engineering --have used a new method called dynamic optical projection stereolithography (DOPsL) to grow a fractal network of 3D blood vessels out of soft biocompatible gel.
In recent years stereolithography has become a big deal in the world of manufacturing of machinery and vehicles, given its ability to create 3D parts or dies. Alternatives -- such as two-photon photopolymerization -- remain far slower and less efficient, taking hours to make a part.
UCSD researchers grew a blood vessel network, using stereolithography.
[Image Source: Chen Group/UCSD]
But for all its promise, work to adapt stereolithography to a microscopic scale is still in its rudimentary beginnings.
Funded by a $1.5M USD grant from the
National Institutes of Health
, the UCSD team created a working prototype of micromirrors, which direct light to solidify photosensitive liquid biogel. Controlled by the computer, the mirrors were able to pattern a network of 3D blood vessels in mere seconds.
The team -- led by NanoEngineering
Professor Shaochen Chen
-- says they're still a long way from simply growing blood cells to replacement organs. In the short term, however, the technology will likely first be applied to attempts to better grow and differentiate diverse tissues in the lab. For example the method could add vasculature to a growing cardiac tissue, improving its survival.
Eventually, Professor Chen, like many of his colleagues around the country, envisions a future in which mankind can simply "print" rich multi-tissue replacement organs -- say a heart, kidney, or liver -- then populate the framework with stem cells and chemicals, grow it for a couple months, then finally pop the finished product into a human.
The technology could eventually be applied to growing livers and other replacement organs.
[Image Source: Toronto Transplant Institute]
They're working hard to reach that goal, and stereolithography may play a crucial role in getting there, now that it's hit the scene.
"It's okay. The scenarios aren't that clear. But it's good looking. [Steve Jobs] does good design, and [the iPad] is absolutely a good example of that." -- Bill Gates on the Apple iPad
UC San Diego Develops Injectable Hydrogel for Cardiac Tissue Repair
February 23, 2012, 11:10 AM
Lab-Grown Arteries More Elastic Than Ever
February 1, 2011, 10:22 AM
Human Liver Cells Used to Successfully Engineer Miniature, Functional Livers
October 31, 2010, 6:14 PM
PIQ ROBOTTM reveals its new artificial intelligence software
November 29, 2016, 12:59 AM
One more time - Happy Thanksgiving to Everyone Around the World
November 24, 2016, 4:00 AM
Google’s Smart Contact Lens Project gets halted for 2016
November 20, 2016, 7:00 AM
Cell Research Study shows African Americans have greater immune response to infection
November 10, 2016, 1:00 AM
UTHealth Clinical Trial Shows Progress Using Stem Cells to Treat Traumatic Brain Injury
November 8, 2016, 1:00 AM
Uber Partners with Circulation to Pilot Program Connecting Transportation and Digital Health Care
November 6, 2016, 5:00 AM
Most Popular Articles
Apple iPad – New Faster Processor and More Fun
March 22, 2017, 7:25 AM
OnePlus 3T – 5.5” Optic AMOLED and Dash Charging Technology
March 23, 2017, 8:45 AM
Comparison – Samsung Galaxy TabPro S Vs Microsoft Surface Pro 4
March 21, 2017, 7:40 AM
Huawei P8 Lite 2017 – Android 7 Nougat Smartphone with Octa-Core Processor
March 8, 2017, 7:03 AM
Gigabyte GA-Z170X-Gaming G1 – Intel Thunderbolt 3 Certified Motherboard
March 9, 2017, 6:25 AM
Latest Blog Posts
More Apps From Google
Mar 28, 2017, 7:15 AM
Are you thinking of performance and speed? Intel claims:
Mar 25, 2017, 7:45 AM
Apple buys an automation app called Workflow. The deal was completed today and brings the app along with its developers.
Mar 23, 2017, 7:35 AM
Apple Announces new color for iPhones and iPads
Mar 22, 2017, 7:45 AM
Instagram: You Can Now Save Live Videos For Later
Mar 21, 2017, 7:49 AM
Samsung Galaxy S8 to Get New Color Scheme
Mar 20, 2017, 7:45 AM
What else to worry about?
Mar 17, 2017, 6:45 AM
Icon of the Day: Intel/ NVIDIA or Mobileye
Mar 16, 2017, 6:15 AM
JUST IN - Twitter Hijacked : High-Profile Account Accesses
Mar 15, 2017, 7:07 AM
Mar 14, 2017, 7:30 AM
News and Tips
Mar 13, 2017, 6:30 AM
iPhone 8 – May Not Get Curved Screen
Mar 11, 2017, 8:00 AM
California paves way to self-driving car tests without humans
Mar 11, 2017, 7:18 AM
Smart Machines V hackers
Mar 10, 2017, 7:00 AM
Uber Can Resume Autonomous Car Testing in California
Mar 9, 2017, 6:50 AM
Mar 8, 2017, 7:09 AM
Mar 7, 2017, 8:45 AM
World news 3-6
Mar 6, 2017, 5:40 AM
Mar 4, 2017, 7:40 AM
Mixed News of the Day
Mar 4, 2017, 6:32 AM
Jaguar Land Rover invests in ride-sharing
Mar 3, 2017, 7:00 AM
Mixed News of The World:
Mar 2, 2017, 7:02 AM
More Blog Posts
Copyright 2017 DailyTech LLC. -
Terms, Conditions & Privacy Information