New Polymer "PEI" Strengthens Vaccines Against HIV/Herpes/Flu
August 28, 2012 10:45 AM
comment(s) - last by
It completely protected mice from a lethal dose of the flu virus
An international team of scientists has found a new compound that will give vaccines some extra
power against viruses
The research team, hailing from Oxford University as well as Sweden and the United States, has discovered a new adjuvant, which is added to vaccines in order to make them stronger against viruses. The new adjuvant is capable of boosting the
fight against HIV
, the flu and herpes.
The new adjuvant is a polymer called polyethyleneimine (PEI), and it is capable of stimulating immune response to better fight viruses. The vaccine is also made up of part of the virus it's fighting or a dead/disabled pathogen, which helps the vaccine to know what to attack.
Most vaccines today have an adjuvant, with the most popular being alum (an aluminum-based compound). However, alum is not the most potent, and vaccines for the flu need to be reformulated every year because it evolves to escape adjuvants. As for HIV and herpes, there are no effective vaccines for either yet.
That's where PEI comes in. It enhances the battle against all three, according to the research team. After giving mice models just one dose of the PEI-containing vaccine through a nasal droplet, they were protected from a lethal
dose of the flu
When the vaccine contained PEI with a protein from HIV and herpes, mice with either virus had a stronger immune system response than to any other adjuvant before.
"Gaining complete protection against flu from just one immunization is pretty unheard of, even in a study in mice," said Professor Quentin Sattentau of the Dunn School of Pathology at Oxford University. "This gives us confidence that PEI has the potential to be a potent adjuvant for vaccines against viruses like flu or HIV, though there are many steps ahead if it is ever to be used in humans."
This article is over a month old, voting and posting comments is disabled
8/29/2012 2:27:21 PM
"However, alum is not the most potent, and vaccines for the flu need to be reformulated every year because it evolves to escape adjuvants."
No. Vaccines need to be reformulated due to both inherent mutation during viral replication and selective pressures that select for mutants better able to evade host immune responses.
"If you mod me down, I will become more insightful than you can possibly imagine." -- Slashdot
FDA Approves HIV Prevention Pill "Truvada"
July 16, 2012, 11:01 PM
MIT Researchers May Have Found Cure for the Common Cold, Other Viruses
August 29, 2011, 9:22 PM
NASA Concerned with Fate of Spirit Rover
November 12, 2008, 12:50 PM
Chagrined Over Leaks, CDC Confirms First U.S. Ebola Diagnosis in Dallas, Texas
September 30, 2014, 5:55 PM
Nail Polish May Soon be Able to Detect Date Rape Drugs
August 26, 2014, 7:57 AM
SpaceX Falcon 9-R Rocket Suffers Malfunction, Self-Destructs During Test Flight
August 23, 2014, 9:36 AM
Texas Chosen as Site for SpaceX's First Commercial Launchpad
August 5, 2014, 1:44 PM
South Carolina Prison Finds Crashed Drone Carrying Drugs, Phones
August 1, 2014, 2:49 PM
NASA's Mars 2020 Rover Gains Seven New Instruments for Exploration
August 1, 2014, 1:30 PM
Most Popular Articles
New AT&T Mobile Share Value "Double Data" Promotion Lasts Through October
September 28, 2014, 8:32 AM
Update: Apple Releases iOS 8.0.2 Update to Make Up for Botched 8.0.1 Release
September 25, 2014, 8:19 PM
Appalling Negligence: Decade-Old Windows XPe Holes Led to Home Depot Hack
September 8, 2014, 8:58 PM
TiVo Mega Features 24TB of Storage, Can Record Three Years* Worth of TV Content
September 8, 2014, 8:45 AM
FBI Outraged That Apple, Google are Adopting Digital "Locks" to Protect Users
September 26, 2014, 1:00 PM
Latest Blog Posts
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
Space Terrorism is a Looming Threat For the United States
Apr 23, 2014, 7:47 PM
Facebook Aims to Provide Internet to "Every Person in the World" with Drones, Satellites
Apr 1, 2014, 10:20 AM
Retail Mobile Sites Experience Outages in Light of Simplexity's Bankruptcy
Mar 14, 2014, 8:48 AM
More Blog Posts
Copyright 2014 DailyTech LLC. -
Terms, Conditions & Privacy Information