New Polymer "PEI" Strengthens Vaccines Against HIV/Herpes/Flu
August 28, 2012 10:45 AM
comment(s) - last by
It completely protected mice from a lethal dose of the flu virus
An international team of scientists has found a new compound that will give vaccines some extra
power against viruses
The research team, hailing from Oxford University as well as Sweden and the United States, has discovered a new adjuvant, which is added to vaccines in order to make them stronger against viruses. The new adjuvant is capable of boosting the
fight against HIV
, the flu and herpes.
The new adjuvant is a polymer called polyethyleneimine (PEI), and it is capable of stimulating immune response to better fight viruses. The vaccine is also made up of part of the virus it's fighting or a dead/disabled pathogen, which helps the vaccine to know what to attack.
Most vaccines today have an adjuvant, with the most popular being alum (an aluminum-based compound). However, alum is not the most potent, and vaccines for the flu need to be reformulated every year because it evolves to escape adjuvants. As for HIV and herpes, there are no effective vaccines for either yet.
That's where PEI comes in. It enhances the battle against all three, according to the research team. After giving mice models just one dose of the PEI-containing vaccine through a nasal droplet, they were protected from a lethal
dose of the flu
When the vaccine contained PEI with a protein from HIV and herpes, mice with either virus had a stronger immune system response than to any other adjuvant before.
"Gaining complete protection against flu from just one immunization is pretty unheard of, even in a study in mice," said Professor Quentin Sattentau of the Dunn School of Pathology at Oxford University. "This gives us confidence that PEI has the potential to be a potent adjuvant for vaccines against viruses like flu or HIV, though there are many steps ahead if it is ever to be used in humans."
This article is over a month old, voting and posting comments is disabled
RE: Fine print
8/28/2012 9:30:22 PM
When you run out of diseases to cure, just engineer new ones! Then you can let them run rampant for a few years before engineering a new drug to combat them.
"If a man really wants to make a million dollars, the best way would be to start his own religion." -- Scientology founder L. Ron. Hubbard
FDA Approves HIV Prevention Pill "Truvada"
July 16, 2012, 11:01 PM
MIT Researchers May Have Found Cure for the Common Cold, Other Viruses
August 29, 2011, 9:22 PM
NASA Concerned with Fate of Spirit Rover
November 12, 2008, 12:50 PM
NASA Considering SpaceX "Red Dragon" for Returning Mars Samples to Earth
March 10, 2014, 2:43 PM
Court Rules that FAA Cannot Ban Commercial Drones, Dismisses $10,000 Fine for Drone User
March 7, 2014, 1:14 PM
Lt. Gen. Davis Says Next Gen USAF Bomber Will "Of Course" Surpass $550M/Unit
March 6, 2014, 9:45 AM
USAF Moves Forward With Long Range Bomber Program Despite Budget Crunch
March 4, 2014, 9:44 AM
Drone Ships May Replace Manned Standard Cargo Ships in the Future
February 27, 2014, 7:48 AM
Military Officer in Charge of Lockheed F-35 Program: We Won't Pay for "Mistake after Mistake"
February 19, 2014, 11:07 AM
Most Popular Articles
Bitcoin King Pt. II: Mt. Gox's Dictator Karpelès Proves Tragically Flawed
March 7, 2014, 1:12 PM
Windows 8.1 Update 1 Leaked Early
March 7, 2014, 9:30 AM
Hack Reveals Fallen Bitcoin CEO's Posh Tokyo Penthouse
March 10, 2014, 4:28 PM
Vine Users No Longer Allowed to Post Pornographic Videos
March 7, 2014, 1:47 PM
Staples Closing 225 Stores Across North America
March 7, 2014, 1:24 PM
Latest Blog Posts
Tesla vs. BMW: Who Has the Safer EV?
Feb 1, 2014, 2:56 PM
Justice Leaks Details of Next HTC One Two Flagship Phone
Dec 5, 2013, 4:04 PM
Global Cyber Espionage Concerns Reveal Growing Cyber Armies
Nov 29, 2013, 11:04 AM
Is The Period Becoming an Expression of Anger?
Nov 26, 2013, 2:02 PM
NSA and Congress -- You Will Never Kill the Constitution, It's an Idea
Nov 10, 2013, 2:00 PM
More Blog Posts
Copyright 2014 DailyTech LLC. -
Terms, Conditions & Privacy Information