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Animal models were used to show reduced skeletal and cardiac muscle contractions after exposure to triclosan

A chemical commonly found in hand soaps (among other household products) has been found to be harmful to both humans and the environment. 
The chemical is called triclosan, and it's a chemical that can be found in hand soaps, toothpastes, mouthwash, deodorants, clothes, bedding, carpets, toys, etc. It was introduced 40 years ago to prevent bacterial infections in hospitals. Over time, it has been used more and more for household purposes. 
However, researchers at the University of California - Davis and the University of Colorado have discovered that triclosan actually affects muscular strength in mice, swimming in fish and muscular contractions in skeletal and cardiac cells. 
The researchers reached these conclusions by first exposing living mice to doses of triclosan similar to that humans and animals would be in contact with on a daily basis. After 20 minutes of exposure, the mice had a 25 percent drop in heart function. They also had an 18 percent decrease in grip strength after an hour of exposure.
Next, researchers exposed fathead minnows to triclosan in order to see how the chemical affects life in waterways. After swimming in water containing triclosan for one week, the minnows experienced a huge drop in swimming speeds when participating in swimming tests of both normal conditions and those that simulate the threat of a predator chasing them.
Researchers then exposed isolated heart and skeletal cells to triclosan. The damage was significant, where triclosan disrupted molecular channels in muscle cells that guide the flow of calcium ions. This prevented protein communication that acts as these channels, leading to muscle failure in both the cardiac and skeletal cells. 
"The effects of triclosan on cardiac function were really dramatic," said Nipavan Chiamvimonvat, co-author of the study from UC Davis. "Although triclosan is not regulated as a drug, this compound acts like a potent cardiac depressant in our models."
More research is likely needed before the U.S. Food and Drug Administration (FDA) will do anything about it, but the researchers aren't looking to ban the chemical entirely -- they just want to greatly decrease its ubiquity in household products. 
A separate study in 2010 also showed negative side effects associated with triclosan. University of Michigan researchers discovered that triclosan caused immune system problems in children under 18. 

Source: UC Davis

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RE: That's what you get
By geddarkstorm on 8/16/2012 4:55:24 PM , Rating: 2
Absolutely true. I agree with all you say, except I am not sure about MS and a connection with radioactive isotopes. MS is generally related to other factors and not radioactivity, as far as I know (and I could be outdated here). But it is a good example none the less.

There are a variety of factors in play, and total calories still have a role. But we are inundated with synthetic compounds these days, yet no one has paid much heed (if any) to how these things might be impacting our bioenergetics chronically. Toxicity for instance is typically tested with acute trials, not chronic. Fullerene, which has been around for well over 20 years, finally got its first chronic trial (and was found to double life span in rats, ironically enough), for instance, despite it being everywhere now since it's the chemical base for nanotubes and other carbon based nanotech.

But, any compound that reduced heart contractility by 25% (disrupting calcium channels, and affecting all skeletal muscle contractions) in live animals at the levels commonly encountered through such soaps, is something to immediately avoid. And it will very likely have a profound effect on metabolism over chronic periods of time; as muscles are one of the primary regulators of your insulin sensitivity and fat storage versus burning/waste signals. Start disrupting their ability to function, and you'll disrupt whole body energy balance.

RE: That's what you get
By Ammohunt on 8/16/2012 10:20:11 PM , Rating: 2
Whatever happened to phenotypes for humans? People now are classified by their BMI which it total BS since it doesn't account for muscle being heavier than fat. /rant
I agree body chemistry is so incredibly complex there is now good way to tell if an otherwise benign industrial chemical is acting on a cell receptor or as a hormone and just how that would manifest as symptoms. I think back when I grew up when leaded gas was the standard; I like to say before lead was poisonous and wonder as a child how much lead did I inadvertently inhale from exhaust?

RE: That's what you get
By Jeffk464 on 8/17/2012 10:30:26 AM , Rating: 2
What your saying is true, the reason they use BMI is its cheap and simple. More effective tests like the water displacement test are much more accurate. Or you could just have an expert that pinches people's fat around their mid sections and says, your fat. :)

To be fair the BMI does include a pretty wide range of normal weight to include different body types. It just misses the super thin framed and weight lifters.

RE: That's what you get
By Ammohunt on 8/17/2012 2:20:58 PM , Rating: 2
what frightens me is that the BMI will be used by the Government now to make judgements on what healthcare you receive or don't receive.

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