Human Stem Cell Trial Repairs Jaw/Mouth Bone Deficiencies
August 1, 2012 3:36 PM
comment(s) - last by
severe jaw deficiency
The stem cells, which are tissue repair cells called ixmyelocel-T, are used to re-grow craniofacial tissue
Humans with jawbone deficiencies in need of dental implants could benefit from a
new stem cell trial
conducted by Michigan researchers.
Darnell Kaigler, study leader from the University of Michigan School of Dentistry, along with William Giannobile, co-author and director of the Michigan Center for Oral Health Research, and Aastrom Biosciences Inc. collaborated to create a stem cell-based method for bone regeneration.
"In patients with jawbone deficiencies who also have missing teeth, it is very difficult to replace the missing teeth so that they look and function naturally," said Kaigler. "This technology and approach could potentially be used to restore areas of bone loss so that missing teeth can be replaced with dental implants."
, which are tissue repair cells called ixmyelocel-T, are used to re-grow craniofacial tissue. They are taken from bone marrow from the patient's own hip and grown using Aastrom Biosciences Inc.'s proprietary system.
To put ixmyelocel-T to the test, the team conducted a human trial where 24 patients with jawbone deficiencies and missing teeth were split into two groups: one that received the stem cell treatment, and the other that received convention bone regeneration treatment.
The stem cells were placed into the mouth and jaw. Patients were observed after six and 12 weeks, and according to the results, those receiving the stem cell treatment experienced faster bone repair and greater bone density than those with traditional bone therapy. Also, the stem cell group required less secondary bone grafting for implants.
This type of treatment could be used for those born with defects or those who've suffered trauma or certain diseases. However, more clinical trials are required before these stem cell therapies can be used regularly.
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8/2/2012 9:56:24 AM
What's wrong with the woman in the before picture exactly? To me she just looks like she's un-attractive and had the bad fortune (and DNA) to be born with a weak chin. Are we calling having a weak chin a "jawbone deficiency" now? I've seen plenty of people like this and thought "Wow...they drew the short straw didn't they?", but never once did I realize this was some sort of medical malady. I kind of see this as nothing more than cosmetic surgery...using stem cells. The artical makes it seem much different than a cosmetic breakthrough. We all know where this is heading. Yep...breast and penis enlargment using stem cells. The one way they can be sure to turn a profit on their research.
8/2/2012 12:17:47 PM
Look up the work of Weston A. Price, most dental/facial development problems are caused by nutrient deficiency in both the mother while pregnant and in the child's diet while growing. I would bet a million dollars that woman's facial development was not a genetic problem, but a lack of adequate nutrition in her and her mother's diet, especially Vitamin K2.
If all future mothers in America got enough Vitamin K2 in their diet starting today, and made sure their kids did as well, the dental industry would start to see a seriously huge drop in new young clients within the next couple decades...
8/2/2012 2:46:46 PM
I look at it and a lightbulb went off--"Oh, that explains the people who look like birds!"
It wasn't a major epiphany but nontheless, it makes me happy that there is now hope for them improving their odds of procreating. It sounds like it'd be less painful in the long run, also, being treated with stemcells and less surgery.
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