Human Stem Cell Trial Repairs Jaw/Mouth Bone Deficiencies
August 1, 2012 3:36 PM
comment(s) - last by
severe jaw deficiency
The stem cells, which are tissue repair cells called ixmyelocel-T, are used to re-grow craniofacial tissue
Humans with jawbone deficiencies in need of dental implants could benefit from a
new stem cell trial
conducted by Michigan researchers.
Darnell Kaigler, study leader from the University of Michigan School of Dentistry, along with William Giannobile, co-author and director of the Michigan Center for Oral Health Research, and Aastrom Biosciences Inc. collaborated to create a stem cell-based method for bone regeneration.
"In patients with jawbone deficiencies who also have missing teeth, it is very difficult to replace the missing teeth so that they look and function naturally," said Kaigler. "This technology and approach could potentially be used to restore areas of bone loss so that missing teeth can be replaced with dental implants."
, which are tissue repair cells called ixmyelocel-T, are used to re-grow craniofacial tissue. They are taken from bone marrow from the patient's own hip and grown using Aastrom Biosciences Inc.'s proprietary system.
To put ixmyelocel-T to the test, the team conducted a human trial where 24 patients with jawbone deficiencies and missing teeth were split into two groups: one that received the stem cell treatment, and the other that received convention bone regeneration treatment.
The stem cells were placed into the mouth and jaw. Patients were observed after six and 12 weeks, and according to the results, those receiving the stem cell treatment experienced faster bone repair and greater bone density than those with traditional bone therapy. Also, the stem cell group required less secondary bone grafting for implants.
This type of treatment could be used for those born with defects or those who've suffered trauma or certain diseases. However, more clinical trials are required before these stem cell therapies can be used regularly.
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RE: Another Adult Stem Cell Win
8/2/2012 9:08:33 AM
Not to mention any hypothetical embryonic stem cell industry would be a virtual dead end at some point. I venture to say in 50 years stem cell therapy will be so common that each person may receive treatment several times a year, probably even for arbitrary applications. What would we do? Take all of our teens and 20-somethings women and put them on conveyor belt and harvest their eggs for everyone's benefit? Yeah, it's sustainable but only until stem cell therapy becomes ubiquitous (which I'm looking forward to).
Also, there's unequivocally less risk associated with using one's own stem cells than those from a foreign body. With embryonic stem cells, with current tech, you're cursed for the remainder of your life of having a suppressed immune system due to immunosuppression drugs - not fun. Could you get away from having to use immunosuppression drugs? Possibly? Does any doctor consider it worth the risk of tissue rejection? Absolutely not...
And by the way, you have to be a numb nut to compare human beings to cattle on a moral level. Every animal deserves a certain level of respect, absolutely. I can wholeheartedly agree that we as a race don't give the respect to mother nature that is due but to suggest we're comparably the same is idiotic. Hey, why not compare us to cabbage and carrots too?
"When an individual makes a copy of a song for himself, I suppose we can say he stole a song." -- Sony BMG attorney Jennifer Pariser
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