Human Stem Cell Trial Repairs Jaw/Mouth Bone Deficiencies
August 1, 2012 3:36 PM
comment(s) - last by
severe jaw deficiency
The stem cells, which are tissue repair cells called ixmyelocel-T, are used to re-grow craniofacial tissue
Humans with jawbone deficiencies in need of dental implants could benefit from a
new stem cell trial
conducted by Michigan researchers.
Darnell Kaigler, study leader from the University of Michigan School of Dentistry, along with William Giannobile, co-author and director of the Michigan Center for Oral Health Research, and Aastrom Biosciences Inc. collaborated to create a stem cell-based method for bone regeneration.
"In patients with jawbone deficiencies who also have missing teeth, it is very difficult to replace the missing teeth so that they look and function naturally," said Kaigler. "This technology and approach could potentially be used to restore areas of bone loss so that missing teeth can be replaced with dental implants."
, which are tissue repair cells called ixmyelocel-T, are used to re-grow craniofacial tissue. They are taken from bone marrow from the patient's own hip and grown using Aastrom Biosciences Inc.'s proprietary system.
To put ixmyelocel-T to the test, the team conducted a human trial where 24 patients with jawbone deficiencies and missing teeth were split into two groups: one that received the stem cell treatment, and the other that received convention bone regeneration treatment.
The stem cells were placed into the mouth and jaw. Patients were observed after six and 12 weeks, and according to the results, those receiving the stem cell treatment experienced faster bone repair and greater bone density than those with traditional bone therapy. Also, the stem cell group required less secondary bone grafting for implants.
This type of treatment could be used for those born with defects or those who've suffered trauma or certain diseases. However, more clinical trials are required before these stem cell therapies can be used regularly.
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RE: Another Adult Stem Cell Win
8/1/2012 9:41:53 PM
Or, we could just use your own adult stem cells to naturally repair your own tissue, instead of injecting cells with an entirely different genome (and a propensity to go cancerous, generate alternate tissue populations, be a target for your immunesystem) into your body. Best yet, no issues of supply since you carry all those regenerative potential cells right there in you. Hey look, everyone's problem is solved. Thanks science.
RE: Another Adult Stem Cell Win
8/1/2012 10:44:12 PM
Adult Stem cells are where research should be pointed. I work with a guy who had cancer they did chemo then injected him with his bothers stem cells and he got his immune system back along with his brothers shell fish allergy. It was much like an organ transplant as far as rejection concerns.
The tech right now points at adult stem cells as being viable cures for many things right now and points at embryonic as maybe someday but not now unless you want complications....
"Intel is investing heavily (think gazillions of dollars and bazillions of engineering man hours) in resources to create an Intel host controllers spec in order to speed time to market of the USB 3.0 technology." -- Intel blogger Nick Knupffer
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