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Bisphenol A is considered a toxic substance in some countries because of the hormone-like properties it possess

A new study shows that bisphenol A exposure could help cause a brain tumor called meningioma.

Bisphenol A (BPA) is an organic compound that is used to make epoxy resins, polycarbonate polymers and other plastics. It is considered a toxic substance in some countries because of the hormone-like properties it possess. Canada and the European Union have even banned it from being used in baby bottles.

Now, a new study from China has revealed that BPA could be a risk factor for meningioma brain tumors. They made this connection by studying 247 patients with meningioma and 258 patients with no cancer history. Each patient had their medical records and history collected for the sake of the study.

All patients were observed at the Union Hospital in Wuhan, China. The researchers would check the brain tumors with brain scans or biopsies while BPA levels were identified through urine samples.

All volunteers were placed into one of four groups, which were determined by the concentration of BPA levels in urine. The groups consisted of less than 0.53 ng/ml, 0.54-0.91 ng/ml, 0.92-1.69 ng/ml, and over 1.69 ng/ml. They determined whether increasing BPA levels in urine were linked to meningioma diagnosis.

According to the results, patients in the latter three groups with the higher BPA concentrations were 1.4 to 1.6 times more likely to be diagnosed with meningioma than those in the lowest BPA level group. The team also found that the association between the two remained consistent despite other factors like BMI, age and gender.

The study noted that this is the first time a link has been shown between BPA exposure and meningioma diagnosis.

Source: Environmental Health News

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By geddarkstorm on 7/3/2012 2:46:59 PM , Rating: 2
Here is a very good report on the matter:

Seems most daily intakes from canned foods are around:
HPFB has previously estimated the probable daily intake (PDI) of BPA for the general population from food packaging uses to be 0.18 µg/kg b.w from tested food cans in 1995, based on the results of food simulant extraction studies conducted on epoxy-lined cans.

That would be about 11 ug in a day, according to Canada.

Importantly, eating 5 mg of BPA results in a urine concentration of 180 ug/ml after 80 minutes, far above what's stated in this study, but it gives us an idea of the dosages these people may have been exposed to. Since they are at most 1.6 ng/ml, that would put them in the range of the daily dosage of BPA from canned foods. Of course, no idea how long after they were exposed that a sample was taken.

It's an interesting discussion. BPA may work at low doses as a sensitizer, making a person vulnerable to other carcinogens. The brain especially is vulnerable to this sort of insult.

"There is a single light of science, and to brighten it anywhere is to brighten it everywhere." -- Isaac Asimov

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