New Skin Cancer Drug Receives FDA Approval in Only 5 Years
June 13, 2012 6:47 PM
comment(s) - last by
Basal cell carcinoma
The drug, called Vismodegib, was first administered to a patient on January 23, 2007
drug has been labeled "the greatest advance in therapy yet seen" by the
New England Journal of Medicine
The skin cancer drug, called Vismodegib, which is being marketed as Erivedge, is intended for skin cancer patients with advanced basal cell carcinoma. It blocks the Hedgehog signaling pathway and treats locally advanced and metastatic basal cell carcinomas. It can also treat basal cell nevus syndrome, which is inherited genetic susceptibility for large basal cell carcinoma development.
Vismodegib was tested by Translational Genomics Research Institute (TGen), Mayo Clinic and Virginia G. Piper Cancer Center at Scottsdale Healthcare.
Vismodegib was first administered to a patient on January 23, 2007. It underwent a Phase 1 clinical trial at the Virginia G. Piper Cancer Center at Scottsdale Healthcare, which partnered with TGen.
"The first patient put on this drug had advanced basal cell cancer, so we suspected that the
tumor had the mutation
this drug is targeted against," said Ramesh K. Ramanathan, M.D., Medical Director at Virginia G. Piper Cancer Center Clinical Trials and Clinical Professor and Deputy Director of the Clinical Translational Research Division at TGen. "And our partnership with Dr. Ronald Korn and his team who did advanced PET imaging helped to really demonstrate the drug's efficacy for Genentech to continue pursuing the additional study."
The first phase was successful, leading to a Phase 2 clinical trial of basal cell carcinoma. Researchers at the Mayo Clinic headed this particular phase.
The success of Phase 2 led to Vismodegib's U.S. Food and Drug Administration (FDA) approval on January 30, 2012. Vismodegib is the first drug to receive FDA approval to treat inoperable basal cell carcinoma. It only took Vismodegib five years to receive FDA approval, which is impressive considering most drugs take about 15 years to achieve this.
"It is a landmark day for patients with basal cell carcinoma and all those involved in their care," said the
New England Journal of Medicine
This article is over a month old, voting and posting comments is disabled
RE: Side effects include
6/14/2012 11:41:03 AM
Yeah. None of these pot smokers is productive:
Just more successful than anyone here...
Oh, and if you listen to music - thank pot for most of your enjoyment.
"So if you want to save the planet, feel free to drive your Hummer. Just avoid the drive thru line at McDonalds." -- Michael Asher
New Rogue Gene Offers Insight on How to Stop Cancer from Spreading
January 24, 2011, 9:04 AM
Scientists Working on Cancer Treatment Using Salmonella Bacteria
August 12, 2010, 10:10 AM
Star Wars Spinoff Film "Rogue One", Theme Park Attractions Announced
August 17, 2015, 12:20 PM
SpaceX Falcon 9's Seventh Supply Mission to ISS Ends w/ Fiery Stage 1 Explosion
June 28, 2015, 1:10 PM
Cool Science Video: Glowing Millipede Prowls the Nevada Desert
May 18, 2015, 12:00 PM
Newly Discovered Costa Rican Glass Frog is Kermit's Doppelgänger
April 22, 2015, 11:26 AM
Researchers Hope to Find "Exotic" Lifeforms Inside Crater of Dinosaur Killing Meteor
April 14, 2015, 8:47 PM
Mathematician's Sociological Formulation May Explain the "Hipster Paradox"
April 14, 2015, 1:13 PM
Most Popular Articles
Why the U.S. Won't be Able to Ban Google's New Huawei Marshmallow Flagship Phone
October 3, 2015, 5:27 PM
Apple's First Fixes to iOS 9 Land w/ iOS 9.0.1 Release
September 23, 2015, 6:11 PM
Apple Watch Commands 2 in 3 Smart Watch Sales, WatchOS 2 Sweetens the Pitch
September 20, 2015, 6:07 PM
Tag Heuer Admits Its $1,800 Smartwatch Was Inspired By Apple -- Price-Wise
September 30, 2015, 6:32 PM
Breaking Bad: How to Crash Google's Chrome Browser With Just 8 Characters
September 23, 2015, 11:08 AM
Latest Blog Posts
Sceptre Airs 27", 120 Hz. 1080p Monitor/HDTV w/ 5 ms Response Time for $220
Dec 3, 2014, 10:32 PM
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
More Blog Posts
Copyright 2015 DailyTech LLC. -
Terms, Conditions & Privacy Information