Synthetic Compounds Cause Weight Loss in Obese Mice; Could Treat Diabetes
March 30, 2012 2:30 PM
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The tiny compounds could eventually help diabetics...like Paula Deen
The pair of tiny molecules caused a decrease in cholesterol and fat mass
Researchers at the Scripps Research Institute in Florida have developed a pair of molecules that could lead to weight loss and one day treat disorders like obesity and
Thomas Burris, study leader and a professor at Scripps Florida, along with a team of researchers, were able to synthesize a pair of tiny molecules that are capable of altering the biological clock in animals.
The small molecules alter the circadian rhythm and pattern of core clock gene expression in the brain’s hypothalamus. Circadian rhythms react to a 24-hour cycle of light and dark while the brain’s hypothalamus relates to the daily rhythms in mammals.
The synthetic compounds activate proteins called REV-ERBα and REV-ERBβ, which are partially responsible for the biological rhythms associated with metabolism in mammals.
The researchers administered the
to obese mice twice a day for 12 days. After the 12 days, researchers tested the mice and found that fat mass, hyperglycemia, and cholesterol levels improved significantly. The mice were given a diet of high fat and high sugar foods, yet still lost weight.
According to the study’s results, cholesterol was reduced by 47 percent and triglycerides in the blood decreased by 12 percent.
The compounds also played a part in controlling the mammals’ activity during night and day, which the researchers believe could be used to control insomnia and other sleep disorders. Researchers found that oxygen consumption increased by 5 percent in mice during the day and night, which means increased energy expenditure, but they found that these increases were not due to increased energy – there was a 15 percent decrease in movement during the same time that oxygen consumption increased.
“The idea behind this research is that our circadian rhythms are coupled with metabolic processes and that you can modulate them pharmacologically,” said Burris. “As it turns out, the effect of that modulation is surprisingly positive – everything has been beneficial so far.”
This study was published in
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4/2/2012 4:19:35 PM
You're oversimplifying a very complex problem. It is true that the only way for the body to accumulate fat is by burning fewer calories than are consumed, but this isn't a simple matter of the eater being too indulgent or too inactive. If the only thing involved was what you eat and how much you move, do you really think ANYONE could stay at a stable weight for any given period of time? Do you believe you eat the same amount, to the Calorie, every month?
Even a 10 Calorie per day difference is a 1 pound per year weight gain. That doesn't sound like much, but it adds up over a lifetime, and 10 Calories per day is insignificant. If it were all a matter of input vs expenditure, our weight would fluctuate wildly.
In reality, there are a lot of factors that go in to weight gain/loss. Gut flora, genetics, hormones, what you eat, how much you eat, etc... All of these factors determine what your body does with the food that you put into it. Also, your metabolism is more effected by certain types of activities. You could spend 6 hours on a treadmill and get less benefit than you could 1 hour of interval training. And, I could spend 1 hour doing interval training and get less benefit than you could doing 1 hour of interval training.
You can't just look at a fat person and say "You eat too much and are lazy." It just isn't accurate (in all cases).
4/3/2012 11:46:54 AM
False. It is a very simple problem.
Yes most people do stay at a fairly stable weight, gaining a few pounds as they age due to lowered metabolism vs calorie consumption.
People don't actually stay at a completely stable weight, varying a few pounds every year unless they closely monitor their weight and adjust diet or activity level to compensate.
I can and do look at a fat person and think "they eat more calories than they burn". This is not a mystical situation, not even the tiniest bit complex.
EVERYONE who applies what I wrote will have control of their weight, though too often people either don't care about their weight (which is their right to choose), care less about it than eating what they want, or eat in excess due to emotional issues or environmental ones (in cold climates, an insulating fat layer is beneficial).
All the things you mention are irrelevant. No matter how much they might play a role the bottom line is no different for anyone. So long as a person is a biological entity that burns calories for energy, reducing the calorie to metabolic ratio will result in lower fat accumulation and in extension, burning fat.
Lazy? Your word not mine. I'm not the type of person who thinks someone else should do any particular thing. I'd like it if everyone were at their ideal healthy weight but I like more the freedom to live one's life as they choose.
"Young lady, in this house we obey the laws of thermodynamics!" -- Homer Simpson
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