Synthetic Compounds Cause Weight Loss in Obese Mice; Could Treat Diabetes
March 30, 2012 2:30 PM
comment(s) - last by
The tiny compounds could eventually help diabetics...like Paula Deen
The pair of tiny molecules caused a decrease in cholesterol and fat mass
Researchers at the Scripps Research Institute in Florida have developed a pair of molecules that could lead to weight loss and one day treat disorders like obesity and
Thomas Burris, study leader and a professor at Scripps Florida, along with a team of researchers, were able to synthesize a pair of tiny molecules that are capable of altering the biological clock in animals.
The small molecules alter the circadian rhythm and pattern of core clock gene expression in the brain’s hypothalamus. Circadian rhythms react to a 24-hour cycle of light and dark while the brain’s hypothalamus relates to the daily rhythms in mammals.
The synthetic compounds activate proteins called REV-ERBα and REV-ERBβ, which are partially responsible for the biological rhythms associated with metabolism in mammals.
The researchers administered the
to obese mice twice a day for 12 days. After the 12 days, researchers tested the mice and found that fat mass, hyperglycemia, and cholesterol levels improved significantly. The mice were given a diet of high fat and high sugar foods, yet still lost weight.
According to the study’s results, cholesterol was reduced by 47 percent and triglycerides in the blood decreased by 12 percent.
The compounds also played a part in controlling the mammals’ activity during night and day, which the researchers believe could be used to control insomnia and other sleep disorders. Researchers found that oxygen consumption increased by 5 percent in mice during the day and night, which means increased energy expenditure, but they found that these increases were not due to increased energy – there was a 15 percent decrease in movement during the same time that oxygen consumption increased.
“The idea behind this research is that our circadian rhythms are coupled with metabolic processes and that you can modulate them pharmacologically,” said Burris. “As it turns out, the effect of that modulation is surprisingly positive – everything has been beneficial so far.”
This study was published in
This article is over a month old, voting and posting comments is disabled
3/30/2012 9:41:42 PM
Paranoid much? I actually think that "they" simply don't care as long as "they" make money. I don't think that it's a huge conspiracy. Your point is well taken though. I'd invite you to look at turkeys and chickens as well. The Butterball broadbreasted white turkey is a monster that won't live much past a year because it is so massive that the poor things heart wears out to feed the enormous breast muscles (turkey cardiomyopathy!). They have no flavor aside from whatever is injected into them by the processor. Chickens are so medicated (we were taught to use tylosin powder in the water) so that they can be raised in huge numbers in tiny areas that they have osteoporosis from lack of load bearing exercise, and they have almost no flavor either. Have you had a real, family farmed chicken recently? Real chicken flavor, bright yellow color from the fats, and much less meat than you'd expect for the weight-- because their bones have normal mass to them! Education is so important. People need to know that real food doesn't look perfect, but tastes great! I also love that dairy got it's own section of the food guide. How much do you think that cost the dairy lobby? You can get EVERYTHING that's in milk from so many other sources that aren't even mentioned, even in some higher level nutrition classes!
"When an individual makes a copy of a song for himself, I suppose we can say he stole a song." -- Sony BMG attorney Jennifer Pariser
Growth Hormone Deficiency May Prevent Diabetes, Cancer
February 18, 2011, 6:24 AM
New Compound Could Protect Brain Cells, Fight Neurodegenerative Diseases
December 8, 2010, 10:09 AM
SpaceX Falcon 9's Seventh Supply Mission to ISS Ends w/ Fiery Stage 1 Explosion
June 28, 2015, 1:10 PM
Cool Science Video: Glowing Millipede Prowls the Nevada Desert
May 18, 2015, 12:00 PM
Newly Discovered Costa Rican Glass Frog is Kermit's Doppelgänger
April 22, 2015, 11:26 AM
Researchers Hope to Find "Exotic" Lifeforms Inside Crater of Dinosaur Killing Meteor
April 14, 2015, 8:47 PM
Mathematician's Sociological Formulation May Explain the "Hipster Paradox"
April 14, 2015, 1:13 PM
Cool Science Video: This is What a McDonald's Burger Looks Like in Your Stomach
April 7, 2015, 1:43 PM
Most Popular Articles
Exclusive: If Intel and Micron's "Xpoint" is 3D Phase Change Memory, Boy Did They Patent It
July 29, 2015, 10:52 PM
Windows 10 to Get New Features in October Service Release 2 (SR2)
July 30, 2015, 5:50 PM
Quick Note: Apple Watch to Get Brick and Mortar Boost From Best Buy
July 27, 2015, 3:00 PM
Cortana Help Button is Coming Soon for $23
July 30, 2015, 5:07 PM
As iPad Sales Wane and Watch Flops, iPhone Saves Apple's Profit With Its Heroics
July 22, 2015, 6:13 PM
Latest Blog Posts
Sceptre Airs 27", 120 Hz. 1080p Monitor/HDTV w/ 5 ms Response Time for $220
Dec 3, 2014, 10:32 PM
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
More Blog Posts
Copyright 2015 DailyTech LLC. -
Terms, Conditions & Privacy Information