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The tiny compounds could eventually help Paula Deen  (Source:
The pair of tiny molecules caused a decrease in cholesterol and fat mass

Researchers at the Scripps Research Institute in Florida have developed a pair of molecules that could lead to weight loss and one day treat disorders like obesity and diabetes.
Thomas Burris, study leader and a professor at Scripps Florida, along with a team of researchers, were able to synthesize a pair of tiny molecules that are capable of altering the biological clock in animals.
The small molecules alter the circadian rhythm and pattern of core clock gene expression in the brain’s hypothalamus. Circadian rhythms react to a 24-hour cycle of light and dark while the brain’s hypothalamus relates to the daily rhythms in mammals.
The synthetic compounds activate proteins called REV-ERBα and REV-ERBβ, which are partially responsible for the biological rhythms associated with metabolism in mammals.
The researchers administered the synthetic compounds to obese mice twice a day for 12 days. After the 12 days, researchers tested the mice and found that fat mass, hyperglycemia, and cholesterol levels improved significantly. The mice were given a diet of high fat and high sugar foods, yet still lost weight.
According to the study’s results, cholesterol was reduced by 47 percent and triglycerides in the blood decreased by 12 percent.
The compounds also played a part in controlling the mammals’ activity during night and day, which the researchers believe could be used to control insomnia and other sleep disorders. Researchers found that oxygen consumption increased by 5 percent in mice during the day and night, which means increased energy expenditure, but they found that these increases were not due to increased energy – there was a 15 percent decrease in movement during the same time that oxygen consumption increased.
“The idea behind this research is that our circadian rhythms are coupled with metabolic processes and that you can modulate them pharmacologically,” said Burris. “As it turns out, the effect of that modulation is surprisingly positive – everything has been beneficial so far.”
This study was published in Nature.

Source: Science Daily

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RE: progress!
By Noya on 3/30/2012 9:07:49 PM , Rating: 0
Well said.

People seem to have this mentality that if it's for sale at the store, it's perfectly fine to consume or use (BPA).

With all the warnings on cigarettes and medications, how about warnings on processed products that say:
"this edible product contains virtually no nutrients and many possibly harmful chemicals that cause cancer in mice- consume at your own risk"

I mean, you can't even just grab an apple and be safe as most non-organic apples are loaded with pesticides. Next time you're at the store, pick up an organic and non-organic apple of the same breed. Notice how massive and odd shaped the non-organic apple is? Take a big whiff of them and notice the chemical scent coming off the Frankenstein version. Hell, even have one of the produce guys slice them open and taste the difference. The organic will be sweet (breed dependent) and natural tasting while the regular will be slightly bitter and have a chemical aftertaste like a diet soda. Strawberries are even worse, probably the biggest difference.

It's like this country is strictly meant to fuck us over from birth to grave. Take 30% of people wages and tax EVERYTHING, while offering nothing in return aside from crumbling infrastructure, pathetic schools, cops that just handout tickets, fire/EMT that cost you thousands if you actually need them, a beyond crooked banking system, exuberantly priced higher education, shipping away 99% of manufacturing jobs while letting in millions of illegals to work for slave wages for the HUGE industrial/processed food conglomerates, etc., etc. Load the main, affordable "food" supply with so many chemical poisons that people get sick (obese, diabetes, cancer, etc) while the price of healthcare goes through the roof. And lets make the healthcare an after the fact band-aid instead of teaching "wellness" and preventative measures that help ensure long-term health.

For Christs sake just look at the old Food Pyramid they crammed on you in school with empty carbs at the bottom and dairy with its own section...can we say lobbying?

RE: progress!
By macawvet on 3/30/2012 9:41:42 PM , Rating: 2
Paranoid much? I actually think that "they" simply don't care as long as "they" make money. I don't think that it's a huge conspiracy. Your point is well taken though. I'd invite you to look at turkeys and chickens as well. The Butterball broadbreasted white turkey is a monster that won't live much past a year because it is so massive that the poor things heart wears out to feed the enormous breast muscles (turkey cardiomyopathy!). They have no flavor aside from whatever is injected into them by the processor. Chickens are so medicated (we were taught to use tylosin powder in the water) so that they can be raised in huge numbers in tiny areas that they have osteoporosis from lack of load bearing exercise, and they have almost no flavor either. Have you had a real, family farmed chicken recently? Real chicken flavor, bright yellow color from the fats, and much less meat than you'd expect for the weight-- because their bones have normal mass to them! Education is so important. People need to know that real food doesn't look perfect, but tastes great! I also love that dairy got it's own section of the food guide. How much do you think that cost the dairy lobby? You can get EVERYTHING that's in milk from so many other sources that aren't even mentioned, even in some higher level nutrition classes!

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