New Breast Implant Reduces Risk of Cancer Relapse
March 26, 2012 5:17 PM
comment(s) - last by
A bumpy “bed of nails” surface does not allow cancerous cells to gather the nutrients they need
(Source: Webster Lab/Brown University)
A reconstructed surface of the implant pushes malignant cancer cells away and welcomes healthy endothelial cells
Brown University researchers have created a breast implant that reduces the chance of
breast cancer relapse
Thomas Webster, study leader and associate professor of engineering at Brown University, and a team of researchers, have developed a special implant capable of drawing in healthy endothelial cells for those who have had breast tumors removed.
When breast cancer patients have a tumor removed, many have some sort of breast reconstruction completed. Implants are common solutions, but even after the tumor is removed, the American Cancer Society says malignant cells return in about one-fifth of women diagnosed.
To provide a form of breast reconstruction and to prevent relapse, Brown University researchers made an implant made of a common, federally approved polymer with a "bed of nails" surface at the nanoscale level. This surface reduces the blood-vessel construction that cancer cells thrive on, and even lures in healthy endothelial cells for the breast tissue.
The biodegradable polymer was made with 23-nanometer-diameter polystyrene beads and polylactic-co-glycolic acid (PLGA). The implant's PLGA surface had 23-nanometer peak surfaces as well as 300-nanometer and 400-nanometer peaks.
According to lab results, the 23-nanometer surfaces provided a 15 percent decrease in the production of the VEGF protein, which
breast cancer cells
depend on. The 23-nanometer surfaces were better at keeping the protein away than the 300 and 400-nanometer surfaces, but researchers are unsure why. They also found that the 23-nanometer peaks attracted 15 percent more healthy endothelial cells compared to regular surfaces.
The stiffness of malignant breast cancer cells that are unable to latch onto the bumpy surface because the raised surface acts as a bed of nails.
"We've created an (implant) surface with features that can decrease (cancerous) cell functions without having to use chemotherapeutics, radiation or other processes to kill cancer cells," said Webster. "It's a surface that's hospitable to
healthy breast cells
and less so for cancerous breast cells."
The researchers are now working on other potential surfaces that can send cancer cells packing, and are also testing other materials to get the job done.
This article is over a month old, voting and posting comments is disabled
3/27/2012 10:19:28 AM
She said breast
"Spreading the rumors, it's very easy because the people who write about Apple want that story, and you can claim its credible because you spoke to someone at Apple." -- Investment guru Jim Cramer
Researchers Discover Possible Breast Cancer Biomarker in "Junk" DNA
December 17, 2010, 11:00 AM
Discovery Sheds New Light on How Cancer Cells Infect Healthy Tissue
December 13, 2010, 5:53 PM
New Microfluidic Device Helps Identify and Capture Breast Cancer Cells
September 29, 2010, 11:21 AM
Creationists are Mad About Google Doodle Depicting Evolution
November 24, 2015, 8:48 PM
DHS and TSA: Whoops, We Missed That 73 Airport Employees May be Terrorists
November 19, 2015, 2:16 PM
Star Wars Spinoff Film "Rogue One", Theme Park Attractions Announced
August 17, 2015, 12:20 PM
SpaceX Falcon 9's Seventh Supply Mission to ISS Ends w/ Fiery Stage 1 Explosion
June 28, 2015, 1:10 PM
Cool Science Video: Glowing Millipede Prowls the Nevada Desert
May 18, 2015, 12:00 PM
Newly Discovered Costa Rican Glass Frog is Kermit's Doppelgänger
April 22, 2015, 11:26 AM
Latest Blog Posts
Sceptre Airs 27", 120 Hz. 1080p Monitor/HDTV w/ 5 ms Response Time for $220
Dec 3, 2014, 10:32 PM
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
More Blog Posts
Copyright 2016 DailyTech LLC. -
Terms, Conditions & Privacy Information