New Breast Implant Reduces Risk of Cancer Relapse
March 26, 2012 5:17 PM
comment(s) - last by
A bumpy “bed of nails” surface does not allow cancerous cells to gather the nutrients they need
(Source: Webster Lab/Brown University)
A reconstructed surface of the implant pushes malignant cancer cells away and welcomes healthy endothelial cells
Brown University researchers have created a breast implant that reduces the chance of
breast cancer relapse
Thomas Webster, study leader and associate professor of engineering at Brown University, and a team of researchers, have developed a special implant capable of drawing in healthy endothelial cells for those who have had breast tumors removed.
When breast cancer patients have a tumor removed, many have some sort of breast reconstruction completed. Implants are common solutions, but even after the tumor is removed, the American Cancer Society says malignant cells return in about one-fifth of women diagnosed.
To provide a form of breast reconstruction and to prevent relapse, Brown University researchers made an implant made of a common, federally approved polymer with a "bed of nails" surface at the nanoscale level. This surface reduces the blood-vessel construction that cancer cells thrive on, and even lures in healthy endothelial cells for the breast tissue.
The biodegradable polymer was made with 23-nanometer-diameter polystyrene beads and polylactic-co-glycolic acid (PLGA). The implant's PLGA surface had 23-nanometer peak surfaces as well as 300-nanometer and 400-nanometer peaks.
According to lab results, the 23-nanometer surfaces provided a 15 percent decrease in the production of the VEGF protein, which
breast cancer cells
depend on. The 23-nanometer surfaces were better at keeping the protein away than the 300 and 400-nanometer surfaces, but researchers are unsure why. They also found that the 23-nanometer peaks attracted 15 percent more healthy endothelial cells compared to regular surfaces.
The stiffness of malignant breast cancer cells that are unable to latch onto the bumpy surface because the raised surface acts as a bed of nails.
"We've created an (implant) surface with features that can decrease (cancerous) cell functions without having to use chemotherapeutics, radiation or other processes to kill cancer cells," said Webster. "It's a surface that's hospitable to
healthy breast cells
and less so for cancerous breast cells."
The researchers are now working on other potential surfaces that can send cancer cells packing, and are also testing other materials to get the job done.
This article is over a month old, voting and posting comments is disabled
RE: I can see it now..
3/27/2012 9:20:14 AM
You guys just made my morning.
"I mean, if you wanna break down someone's door, why don't you start with AT&T, for God sakes? They make your amazing phone unusable as a phone!" -- Jon Stewart on Apple and the iPhone
Researchers Discover Possible Breast Cancer Biomarker in "Junk" DNA
December 17, 2010, 11:00 AM
Discovery Sheds New Light on How Cancer Cells Infect Healthy Tissue
December 13, 2010, 5:53 PM
New Microfluidic Device Helps Identify and Capture Breast Cancer Cells
September 29, 2010, 11:21 AM
United Airlines Puts Boeing's 787 Dreamliner Back in Service
May 20, 2013, 2:52 PM
Obama to "Clarify" His Position on Killing Americans With Drone Strikes
May 20, 2013, 11:22 AM
High School Student Creates Storage Device that Can Charge in 20 Seconds
May 20, 2013, 6:51 AM
Obama Admin Looks to Revive Bill for Greater Media Protection in Wake of AP Controversy
May 16, 2013, 1:47 PM
Notre Dame Designs Camera to Detect Age of Bruise for Abuse Checks
May 16, 2013, 9:05 AM
Report: Climate Change Could Wash Away Historic Jamestown Site Within 100 Years
May 15, 2013, 5:39 PM
Most Popular Articles
Windows 8.1 Will Be Free; Microsoft Holds Onto Struggling ARM Variant
May 14, 2013, 2:57 PM
Google Announces "Pure" Galaxy Nexus S4 for $649, Android Updates
May 15, 2013, 1:42 PM
Bill Gates Gets Teary-Eyed While Discussing Steve Jobs, Shows Off Life-Saving Tech on 60 Minutes
May 13, 2013, 12:30 PM
U.S. Federal Traffic Board Wants to Make Drunk Driving Threshold Far Harsher
May 15, 2013, 11:32 AM
Google's Eric Schmidt: "Don't Be Evil" was Stupid
May 14, 2013, 11:00 AM
Latest Blog Posts
Quick Note: Sony "Teases" PS4 Ahead of Xbox Reveal in New Video
May 20, 2013, 12:33 PM
Nokia Introduces Instagram-Like App of Its Own to Help Lumia Sales
May 20, 2013, 7:10 AM
Parents of Pre-Teen Drivers Commonly Practice Distracted Driving Says Study
May 9, 2013, 7:16 AM
Apple's iOS 7 Running Into Internal Delays Due to Massive Overhaul
May 1, 2013, 4:26 PM
Elon Musk Willing to Spend More Money on Widening of 405 Freeway
Apr 26, 2013, 7:28 PM
More Blog Posts
Copyright 2013 DailyTech LLC. -
Terms, Conditions & Privacy Information