New Weight-Loss Drug Reduces Body Weight in Monkeys, Mice
November 14, 2011 11:42 AM
comment(s) - last by
Anti-obesity drug Adipotide
(Source: University of Texas M. D. Anderson Cancer Center)
The new drug, called Adipotide, attacks white adipose tissue under the skin and around the abdomen
Researchers at the University of Texas MD Anderson Cancer Center have developed a drug that assaults the blood supply of fat cells and led to weight loss in obese rhesus monkeys.
Renata Pasqualini, Ph.D., co-senior author of the study and professor in MD Anderson's David H. Koch Center for Applied Research for Genitourinary Cancers, along with Wadih Arap, M.D., co-senior author of the study and a professor in the Koch Center, and Kirstin Barnhart, D.V.M., Ph.D., veterinary clinical pathologist at MD Anderson's Keeling Center for Comparative Medicine and Research, have created a new weight-loss drug that could potentially reduce accumulated
white fat in humans
Currently, weight-loss drugs work to suppress the appetite or increase metabolism in order to
, but harmful side effects come with the use of such drugs.
Now, Pasqualini and Arap have designed a new drug called Adipotide, which attacks white adipose tissue. This tissue is an unhealthy kind of fat that accumulates around the abdomen and under the skin. Adipotide contains a homing agent that attaches to a protein on the surface of blood vessels that support the fat. A synthetic peptide then triggers cell death, and with a lack of blood supply, the fat cells are reabsorbed.
The drug was used in mice models and rhesus monkey models. Adipotide was able to decrease abdominal circumference, body mass index (BMI) and body fat.
According to the study, the obese mice lost about 30 percent of their body weight while on Adipotide. The rhesus monkeys in the study, which were "spontaneously" obese due to overeating and a lack of physical activity, had a 27 percent decrease in abdominal fat levels. The drug reduced the weight of rhesus monkeys by 11 percent in just one month.
The rhesus monkeys, in addition to
, had other health problems associated with their obesity such as metabolic syndrome. This can lead to type 2 diabetes and cardiovascular disease. But those treated with Adipotide used about 50 percent less insulin.
The research team used Magnetic Resonance Imaging (MRI) to gauge abdominal body fat, which discovered the reduction in abdominal fat levels.
According to the study, monkeys were alert and acted normally during treatment. This showed that the usual side effects of weight-loss drugs, such as loss of appetite and nausea, were not present while using Adipotide. However, Barnhart noted side effects in the kidneys, but the effect was "dose-dependent, predictable and reversible."
In a separate study to test for the drug's effects in non-obese monkeys, lean monkeys did not lose weight, which shows that the drug only acts in obese subjects.
The next step will be a clinical trial for obese prostate cancer patients, where these patients will receive daily injections of Adipotide for 28 days. The team has targeted prostate cancer patients because current treatments can lead to weight gain, and weight gain has caused problems with arthritis. This then leads to less activity, and more weight gain.
"The question is, will their prostate cancer become better if we can reduce their body weight and the associated health risks," said Arap.
was published in
This article is over a month old, voting and posting comments is disabled
RE: I find it interesting that...
11/15/2011 1:40:26 PM
"Am I my brothers keeper?" Just because I see someone doing something that they can "control", doesn't mean I should necessarily degrade them over it and discriminate them does it?
Alcoholics have a choice too, except they are even given more respect than overweight people and smokers because we've cooked up this crock about it being a "disease" so we can excuse their behavior. I've never heard of a medical condition that forced you to walk into a liquor store, but there you have it.
RE: I find it interesting that...
11/15/2011 2:15:27 PM
Honestly I'm proud to be fat cause when the nuclear holocaust comes I can survive much longer with no food :). Just means I have to build a slightly larger bomb shelter
RE: I find it interesting that...
11/17/2011 1:20:06 PM
"Necessarily"? Since when was there a mandate to discriminate anyone? Mockery is a part of human nature, and if it's for somebody choosing something clearly deleterious to himself or others, I'm all for it.
I've never heard of alcoholics being off limits because it's now being considered a disease. I don't know why drinkers get respect, but I guess it has to do with them being assumed to either be manly, party animals, and/or an easy lay. Still, there's plenty of denigration being thrown their way..
"A lot of people pay zero for the cellphone ... That's what it's worth." -- Apple Chief Operating Officer Timothy Cook
Gene "KLF14" Acts as Switch for Type 2 Diabetes, Obesity
May 16, 2011, 11:54 AM
Turning White Fat into Brown Fat Could Curb Obesity in Humans
May 5, 2011, 3:50 PM
World Has Grown Much, Much Fatter: Obesity Doubles in 30 Years
February 4, 2011, 11:03 AM
Star Wars Spinoff Film "Rogue One", Theme Park Attractions Announced
August 17, 2015, 12:20 PM
SpaceX Falcon 9's Seventh Supply Mission to ISS Ends w/ Fiery Stage 1 Explosion
June 28, 2015, 1:10 PM
Cool Science Video: Glowing Millipede Prowls the Nevada Desert
May 18, 2015, 12:00 PM
Newly Discovered Costa Rican Glass Frog is Kermit's Doppelgänger
April 22, 2015, 11:26 AM
Researchers Hope to Find "Exotic" Lifeforms Inside Crater of Dinosaur Killing Meteor
April 14, 2015, 8:47 PM
Mathematician's Sociological Formulation May Explain the "Hipster Paradox"
April 14, 2015, 1:13 PM
Most Popular Articles
Windows 10 Hits 75 Million Users; Grows Nearly 4x as Fast as Windows 7
August 28, 2015, 10:22 PM
Kentucky Man Faces up to 10 Years in Prison for Shooting Drone Trespasser
August 13, 2015, 2:58 PM
Microsoft's Flagship Windows10 Lumias Rumored to Pack 25 Minute Charge Times
August 31, 2015, 8:13 PM
Report: Over 25 Million Devices Upgraded to Windows 10... or Was It 67 Million?
August 7, 2015, 3:24 PM
Microsoft Announces $499 Xbox One "ELITE", w/ High-End Controller, Hybrid HDD
August 31, 2015, 3:29 PM
Latest Blog Posts
Sceptre Airs 27", 120 Hz. 1080p Monitor/HDTV w/ 5 ms Response Time for $220
Dec 3, 2014, 10:32 PM
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
More Blog Posts
Copyright 2015 DailyTech LLC. -
Terms, Conditions & Privacy Information