New Weight-Loss Drug Reduces Body Weight in Monkeys, Mice
November 14, 2011 11:42 AM
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Anti-obesity drug Adipotide
(Source: University of Texas M. D. Anderson Cancer Center)
The new drug, called Adipotide, attacks white adipose tissue under the skin and around the abdomen
Researchers at the University of Texas MD Anderson Cancer Center have developed a drug that assaults the blood supply of fat cells and led to weight loss in obese rhesus monkeys.
Renata Pasqualini, Ph.D., co-senior author of the study and professor in MD Anderson's David H. Koch Center for Applied Research for Genitourinary Cancers, along with Wadih Arap, M.D., co-senior author of the study and a professor in the Koch Center, and Kirstin Barnhart, D.V.M., Ph.D., veterinary clinical pathologist at MD Anderson's Keeling Center for Comparative Medicine and Research, have created a new weight-loss drug that could potentially reduce accumulated
white fat in humans
Currently, weight-loss drugs work to suppress the appetite or increase metabolism in order to
, but harmful side effects come with the use of such drugs.
Now, Pasqualini and Arap have designed a new drug called Adipotide, which attacks white adipose tissue. This tissue is an unhealthy kind of fat that accumulates around the abdomen and under the skin. Adipotide contains a homing agent that attaches to a protein on the surface of blood vessels that support the fat. A synthetic peptide then triggers cell death, and with a lack of blood supply, the fat cells are reabsorbed.
The drug was used in mice models and rhesus monkey models. Adipotide was able to decrease abdominal circumference, body mass index (BMI) and body fat.
According to the study, the obese mice lost about 30 percent of their body weight while on Adipotide. The rhesus monkeys in the study, which were "spontaneously" obese due to overeating and a lack of physical activity, had a 27 percent decrease in abdominal fat levels. The drug reduced the weight of rhesus monkeys by 11 percent in just one month.
The rhesus monkeys, in addition to
, had other health problems associated with their obesity such as metabolic syndrome. This can lead to type 2 diabetes and cardiovascular disease. But those treated with Adipotide used about 50 percent less insulin.
The research team used Magnetic Resonance Imaging (MRI) to gauge abdominal body fat, which discovered the reduction in abdominal fat levels.
According to the study, monkeys were alert and acted normally during treatment. This showed that the usual side effects of weight-loss drugs, such as loss of appetite and nausea, were not present while using Adipotide. However, Barnhart noted side effects in the kidneys, but the effect was "dose-dependent, predictable and reversible."
In a separate study to test for the drug's effects in non-obese monkeys, lean monkeys did not lose weight, which shows that the drug only acts in obese subjects.
The next step will be a clinical trial for obese prostate cancer patients, where these patients will receive daily injections of Adipotide for 28 days. The team has targeted prostate cancer patients because current treatments can lead to weight gain, and weight gain has caused problems with arthritis. This then leads to less activity, and more weight gain.
"The question is, will their prostate cancer become better if we can reduce their body weight and the associated health risks," said Arap.
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RE: Reduce your daily caloric intake
11/14/2011 3:37:36 PM
I recently lost almost 50 pounds, and I can tell you that losing weight is a major pain in the %#@. It's more than just the willpower you need to go to bed hungry every night, it's things like waking up early enough to make yourself a salad so you don't have to depend on fast food for lunch, and it's constantly begging off going out with your friends because you know you'll drink if you do. Or just budgeting the time you need to exercise the hour+ you need to each day.
If science gives us a magic pill that lets people lose weight without having to go through all that, I say great. The whole point of technology is to make people's lives easier. Give this drug to everyone on the planet and let them eat cheesecake.
Although I will say that losing weight the hard way gave me an incredible since of accomplishment.
RE: Reduce your daily caloric intake
11/14/2011 5:22:45 PM
And you'll die young because of side effects from the drug, or from heart disease because you didn't exercise enough.
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