Scientists Successful in Rejuvenating Cells in Elderly Patients
November 8, 2011 11:42 AM
A research team has accomplished the rejuvenation of cells from elderly donors, which could prove to be beneficial for regenerative medicine
A research team from the Functional Genomics Institute has successfully
from elderly donors in vitro to induced pluripotent stem cells (iPSC) and to rejuvenated human embryonic stem cells (hESC).
Jean-Marc Lemaitre, study leader and Inserm researcher at the Functional Genomics Institute (Inserm, CNRS, and Université de Montpellier 1 and 2), and Inserm's AVENIR Genomic plasticity and aging team, have accomplished the rejuvenation of cells from elderly donors, which could prove to be beneficial for regenerative medicine.
Since 2007, research teams have been able to reprogram human adult cells into iPSCs, which have similar traits as hESCs. HESCs are the desired result because they are undifferentiated cells that can form various types of differentiated adult cells in the body. Using embryonic stem cells is out of the question due to
ethical problems with using stem cells from a human embryo
, so researchers have been using different avenues to achieve the same results.
Up until this point, the method of reprogramming human adult cells into iPSCs has been difficult in elderly patients due to senescence, which is the end stage of cellular aging. But Lemaitre and his team were able to surpass this issue. They used older cells taken from donors that were 74, 92, 94, 96 and up to 101-years-old.
Lemaitre and the team first multiplied fibroblasts from a 74-year-old patient. They acquired the senescence distinguished by the "end of cellular proliferation," and finished the in vitro cell reprogramming. When using the four conventional genetic factors typically used, which are OCT4, SOX2, C MYC, KLF4, this feat was not possible. But when adding NANOG and LIN28 to the cocktail, the senescent cells programmed into functional iPSCs and were able to obtain embryonic pluripotent stem cell-like traits once again. The cells were capable of self-renewal and didn't have any traces of aging.
The research team tested the cells' characteristics through the reverse process, where "rejuvenated" iPSCs were once again differentiated into adult cells and compared to the original cells given by the elderly donors. They found that signs of aging were completely gone and the iPSCs can produce functional cells.
The researchers say that this breakthough with iPSCs could lead to techniques to regenerate new tissues and repair failing organs for older patients.
was published in
Genes & Development
"This is about the Internet. Everything on the Internet is encrypted. This is not a BlackBerry-only issue. If they can't deal with the Internet, they should shut it off." -- RIM co-CEO Michael Lazaridis
European Court of Justice Rules Embryonic Stem Cell Research Not Patentable
October 19, 2011, 9:47 AM
Mouse Fat Cells "Reprogrammed" for Clinical Use in Stem Cell Breakthrough
July 27, 2010, 10:26 AM
PIQ ROBOTTM reveals its new artificial intelligence software
November 29, 2016, 12:59 AM
One more time - Happy Thanksgiving to Everyone Around the World
November 24, 2016, 4:00 AM
Google’s Smart Contact Lens Project gets halted for 2016
November 20, 2016, 7:00 AM
Cell Research Study shows African Americans have greater immune response to infection
November 10, 2016, 1:00 AM
UTHealth Clinical Trial Shows Progress Using Stem Cells to Treat Traumatic Brain Injury
November 8, 2016, 1:00 AM
Uber Partners with Circulation to Pilot Program Connecting Transportation and Digital Health Care
November 6, 2016, 5:00 AM
Most Popular Articles
Surface Pro 5 Rumors - New Release Date and Price
April 22, 2017, 6:45 AM
Vivo V5 Plus – the Selfie Softlight is on You.
April 17, 2017, 7:05 AM
What is the Apple’s iPhone 8 specifications and release date?
April 14, 2017, 5:43 AM
Meet the Smartphone with four cameras - Alcatel Flashphone
April 5, 2017, 11:20 AM
ASUS RT-AC5300 – Ultimate Game & 4K Streaming
April 18, 2017, 7:45 AM
Latest Blog Posts
Samsung Galaxy S8 – Warning for Pet Owners
Apr 24, 2017, 5:59 AM
Sound Bars and the Costs?
Apr 23, 2017, 6:30 AM
Link your Brain to Your Computer – In Four Years…Maybe
Apr 22, 2017, 7:03 AM
Google Home can now identify users by their voice.
Apr 21, 2017, 7:15 AM
Amazon Lex – Now Available for Developers.
Apr 20, 2017, 6:58 AM
You can now use Instagram offline on your Android Smartphone
Apr 19, 2017, 8:00 AM
Now you can livestream to YouTube from your mobile device.
Apr 18, 2017, 8:05 AM
Google Home – Is It a Spy Device?
Apr 17, 2017, 7:30 AM
Apple added to self –driving test permit list
Apr 15, 2017, 6:21 AM
Project Scorpio – Coming on June 11
Apr 14, 2017, 6:20 AM
Looks Like Samsung Has Been Forgiven.
Apr 13, 2017, 6:50 AM
United Airlines - Blasted on China’s Social Network and the Stock Market
Apr 12, 2017, 6:50 AM
Amazon's Third-Party Sellers Hacked
Apr 11, 2017, 6:25 AM
Microsoft Surface Pro5 Details Revealed
Apr 9, 2017, 6:41 AM
Own An Android Phone? Then you could be hacked over Wi-FI
Apr 7, 2017, 6:47 AM
Apple confirms iOS 10.3 bug and its effect on iCloud Services
Apr 6, 2017, 6:30 AM
Apple Rolls Out New Version of Apple Music
Apr 5, 2017, 10:35 AM
Apple in the News
Apr 4, 2017, 9:03 AM
Apple iPhones Will Soon Feature Graphics Chips Designed BY Apple
Apr 3, 2017, 6:23 AM
AMD Ryzen Desktop Processors Performance
Apr 2, 2017, 6:30 AM
What makes a camera Lensless?
Apr 1, 2017, 7:45 AM
Google halts Android Wear 2.0 Update Due to Bug
Mar 31, 2017, 7:27 AM
More Blog Posts
Copyright 2017 DailyTech LLC. -
Terms, Conditions & Privacy Information