Scientists Successful in Rejuvenating Cells in Elderly Patients
November 8, 2011 11:42 AM
comment(s) - last by
A research team has accomplished the rejuvenation of cells from elderly donors, which could prove to be beneficial for regenerative medicine
A research team from the Functional Genomics Institute has successfully
from elderly donors in vitro to induced pluripotent stem cells (iPSC) and to rejuvenated human embryonic stem cells (hESC).
Jean-Marc Lemaitre, study leader and Inserm researcher at the Functional Genomics Institute (Inserm, CNRS, and Université de Montpellier 1 and 2), and Inserm's AVENIR Genomic plasticity and aging team, have accomplished the rejuvenation of cells from elderly donors, which could prove to be beneficial for regenerative medicine.
Since 2007, research teams have been able to reprogram human adult cells into iPSCs, which have similar traits as hESCs. HESCs are the desired result because they are undifferentiated cells that can form various types of differentiated adult cells in the body. Using embryonic stem cells is out of the question due to
ethical problems with using stem cells from a human embryo
, so researchers have been using different avenues to achieve the same results.
Up until this point, the method of reprogramming human adult cells into iPSCs has been difficult in elderly patients due to senescence, which is the end stage of cellular aging. But Lemaitre and his team were able to surpass this issue. They used older cells taken from donors that were 74, 92, 94, 96 and up to 101-years-old.
Lemaitre and the team first multiplied fibroblasts from a 74-year-old patient. They acquired the senescence distinguished by the "end of cellular proliferation," and finished the in vitro cell reprogramming. When using the four conventional genetic factors typically used, which are OCT4, SOX2, C MYC, KLF4, this feat was not possible. But when adding NANOG and LIN28 to the cocktail, the senescent cells programmed into functional iPSCs and were able to obtain embryonic pluripotent stem cell-like traits once again. The cells were capable of self-renewal and didn't have any traces of aging.
The research team tested the cells' characteristics through the reverse process, where "rejuvenated" iPSCs were once again differentiated into adult cells and compared to the original cells given by the elderly donors. They found that signs of aging were completely gone and the iPSCs can produce functional cells.
The researchers say that this breakthough with iPSCs could lead to techniques to regenerate new tissues and repair failing organs for older patients.
was published in
Genes & Development
This article is over a month old, voting and posting comments is disabled
11/8/2011 1:32:25 PM
That's because our economical system plainly sucks.
Prolonged life should come along with social changes in the scale of
11/8/2011 1:42:47 PM
While they have noble ideas (many of which are logical but seemingly insurmountable) I find it humorous that with all their talk at removing money and going to a resource-based economy... they have a store where they ask for money to buy information and propaganda. Funny indeed.
11/8/2011 1:53:59 PM
a resource-based economy...
How much food can I get for a consumption information system?
"We basically took a look at this situation and said, this is bullshit." -- Newegg Chief Legal Officer Lee Cheng's take on patent troll Soverain
European Court of Justice Rules Embryonic Stem Cell Research Not Patentable
October 19, 2011, 9:47 AM
Mouse Fat Cells "Reprogrammed" for Clinical Use in Stem Cell Breakthrough
July 27, 2010, 10:26 AM
U.S. Air Force F-35 Lightning II, F-22 Raptor Team Up for “Integration Training”
November 19, 2014, 9:15 AM
U.S. Marshals Using Fake, Airplane-based Cell Towers to Scan Cell Phones of Americans
November 14, 2014, 9:05 AM
Ford Enlists Wind Energy Corp. to Provide Wind, Solar Energy to Four U.S. Dealerships
November 10, 2014, 10:58 AM
Disney Reveals Star Wars Ep. VII Title -- "The Force Awakens"
November 6, 2014, 3:45 PM
U.S. Navy Lockheed F-35C Completes First Carrier Landing
November 4, 2014, 12:44 PM
Microsoft Co-founder Paul Allen Donates $100M to Fight Raging Ebola Epidemic
October 23, 2014, 6:05 PM
Most Popular Articles
Wal-Mart: Miss Thanksgiving, Get Xbox One + Master Chief Collection for $299
November 17, 2014, 9:40 PM
Nokia Lumia 635 LTE Windows Phone is Only $40 at Best Buy on Black Friday
November 18, 2014, 11:59 AM
Uber Exec Threatens to "Spend Millions" to Stalk Female Reporter and Her Family
November 19, 2014, 12:31 PM
Toyota’s Mirai Hydrogen Fuel Cell Vehicle Priced from $57,500 in the U.S.
November 18, 2014, 10:23 AM
Rand Paul Casts Crucial "No" Vote on Obama-Backed PATRIOT Act Renewal Bill
November 19, 2014, 5:15 PM
Latest Blog Posts
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
Space Terrorism is a Looming Threat For the United States
Apr 23, 2014, 7:47 PM
More Blog Posts
Copyright 2014 DailyTech LLC. -
Terms, Conditions & Privacy Information