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  (Source: INSERM)
A research team has accomplished the rejuvenation of cells from elderly donors, which could prove to be beneficial for regenerative medicine

A research team from the Functional Genomics Institute has successfully reprogrammed cells from elderly donors in vitro to induced pluripotent stem cells (iPSC) and to rejuvenated human embryonic stem cells (hESC).

Jean-Marc Lemaitre, study leader and Inserm researcher at the Functional Genomics Institute (Inserm, CNRS, and Université de Montpellier 1 and 2), and Inserm's AVENIR Genomic plasticity and aging team, have accomplished the rejuvenation of cells from elderly donors, which could prove to be beneficial for regenerative medicine.

Since 2007, research teams have been able to reprogram human adult cells into iPSCs, which have similar traits as hESCs. HESCs are the desired result because they are undifferentiated cells that can form various types of differentiated adult cells in the body. Using embryonic stem cells is out of the question due to ethical problems with using stem cells from a human embryo, so researchers have been using different avenues to achieve the same results.

Up until this point, the method of reprogramming human adult cells into iPSCs has been difficult in elderly patients due to senescence, which is the end stage of cellular aging. But Lemaitre and his team were able to surpass this issue. They used older cells taken from donors that were 74, 92, 94, 96 and up to 101-years-old.

Lemaitre and the team first multiplied fibroblasts from a 74-year-old patient. They acquired the senescence distinguished by the "end of cellular proliferation," and finished the in vitro cell reprogramming. When using the four conventional genetic factors typically used, which are OCT4, SOX2, C MYC, KLF4, this feat was not possible. But when adding NANOG and LIN28 to the cocktail, the senescent cells programmed into functional iPSCs and were able to obtain embryonic pluripotent stem cell-like traits once again. The cells were capable of self-renewal and didn't have any traces of aging.

The research team tested the cells' characteristics through the reverse process, where "rejuvenated" iPSCs were once again differentiated into adult cells and compared to the original cells given by the elderly donors. They found that signs of aging were completely gone and the iPSCs can produce functional cells.

The researchers say that this breakthough with iPSCs could lead to techniques to regenerate new tissues and repair failing organs for older patients.

This study was published in Genes & Development.

Source: Science Daily



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RE: SS
By Iaiken on 11/8/2011 1:22:04 PM , Rating: 2
quote:
What if there was a direct and obvious correlation between living past 70 and your net wealth?


On the flip side, there already is a correlation between net wealth and age. If you simply were able to continue to get by on work income and leave your investments alone your would wind up ridiculously wealthy. Even a modest principle return of 7% will double the amount of money you have about every 10 years.

If you have $2 million saved for retirement at 60, at 70 it would be $4 million if you could leave it to grow. By 120 years of age, you would have a staggering $64 million.

Basically, making it so that people can live longer, healthier lives breaks our entire investment economy. Even if you look at the means of prolonging life as a way to take money out of such an economy, that wealth is still there, only then it would be in the hands of the medical companies.


RE: SS
By MrBlastman on 11/8/2011 1:29:18 PM , Rating: 2
Bring on our robot servants!


RE: SS
By Iaiken on 11/8/2011 1:52:08 PM , Rating: 2
If you get a chance to check it out, the novel Altered Carbon actually touches on the idea from my post, but is about a different subject entirely.


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