Scientists Successful in Rejuvenating Cells in Elderly Patients
November 8, 2011 11:42 AM
comment(s) - last by
A research team has accomplished the rejuvenation of cells from elderly donors, which could prove to be beneficial for regenerative medicine
A research team from the Functional Genomics Institute has successfully
from elderly donors in vitro to induced pluripotent stem cells (iPSC) and to rejuvenated human embryonic stem cells (hESC).
Jean-Marc Lemaitre, study leader and Inserm researcher at the Functional Genomics Institute (Inserm, CNRS, and Université de Montpellier 1 and 2), and Inserm's AVENIR Genomic plasticity and aging team, have accomplished the rejuvenation of cells from elderly donors, which could prove to be beneficial for regenerative medicine.
Since 2007, research teams have been able to reprogram human adult cells into iPSCs, which have similar traits as hESCs. HESCs are the desired result because they are undifferentiated cells that can form various types of differentiated adult cells in the body. Using embryonic stem cells is out of the question due to
ethical problems with using stem cells from a human embryo
, so researchers have been using different avenues to achieve the same results.
Up until this point, the method of reprogramming human adult cells into iPSCs has been difficult in elderly patients due to senescence, which is the end stage of cellular aging. But Lemaitre and his team were able to surpass this issue. They used older cells taken from donors that were 74, 92, 94, 96 and up to 101-years-old.
Lemaitre and the team first multiplied fibroblasts from a 74-year-old patient. They acquired the senescence distinguished by the "end of cellular proliferation," and finished the in vitro cell reprogramming. When using the four conventional genetic factors typically used, which are OCT4, SOX2, C MYC, KLF4, this feat was not possible. But when adding NANOG and LIN28 to the cocktail, the senescent cells programmed into functional iPSCs and were able to obtain embryonic pluripotent stem cell-like traits once again. The cells were capable of self-renewal and didn't have any traces of aging.
The research team tested the cells' characteristics through the reverse process, where "rejuvenated" iPSCs were once again differentiated into adult cells and compared to the original cells given by the elderly donors. They found that signs of aging were completely gone and the iPSCs can produce functional cells.
The researchers say that this breakthough with iPSCs could lead to techniques to regenerate new tissues and repair failing organs for older patients.
was published in
Genes & Development
This article is over a month old, voting and posting comments is disabled
RE: I wonder...
11/8/2011 1:19:00 PM
Thankfully, no. ;) That would... "suck."
It would be pretty darned cool to see an old and crotchety man transform before our eyes (okay, not that fast but maybe with time-lapse over a few months) from old and decrepid to a more rejuvinated form.
The best way I can think to do it, other than sticking each cell with a needle, is creating a virus to do all the work for us (as nano-machines are still science fiction). I worry though about the potential immune response to it though... If you change the cells, I doubt it'd change their exterior markers on the cell walls (which our immune system relies on) but I'm not sure.
RE: I wonder...
11/8/2011 6:00:44 PM
Hmmm interesting. However it brings this quote to mind.
"When an individual makes a copy of a song for himself, I suppose we can say he stole a song." -- Sony BMG attorney Jennifer Pariser
European Court of Justice Rules Embryonic Stem Cell Research Not Patentable
October 19, 2011, 9:47 AM
Mouse Fat Cells "Reprogrammed" for Clinical Use in Stem Cell Breakthrough
July 27, 2010, 10:26 AM
Cool Science Video: Glowing Millipede Prowls the Nevada Desert
May 18, 2015, 12:00 PM
Newly Discovered Costa Rican Glass Frog is Kermit's Doppelgänger
April 22, 2015, 11:26 AM
Researchers Hope to Find "Exotic" Lifeforms Inside Crater of Dinosaur Killing Meteor
April 14, 2015, 8:47 PM
Mathematician's Sociological Formulation May Explain the "Hipster Paradox"
April 14, 2015, 1:13 PM
Cool Science Video: This is What a McDonald's Burger Looks Like in Your Stomach
April 7, 2015, 1:43 PM
Fraud Artist Engineered Stunning UK Jailbreak Via Typosquatting, Email
April 4, 2015, 2:57 PM
Most Popular Articles
America's Largest Cable Company, Comcast, Sees Internet Subscriptions Pass TV
May 4, 2015, 2:46 PM
Can id Software's Doom Find Its Way Out of a 7+ Year Development Hell?
May 19, 2015, 7:38 PM
Oculus Rift Confirms "Pause" in OS X, Linux Development, Some Devs are Mad
May 18, 2015, 11:36 PM
The Pirate Bay Loses Its Iconic Swedish Dot SE Domains
May 20, 2015, 6:31 PM
In-Depth: Apple's ~$1B Court Victory Over Samsung to be Cut up to a Third
May 18, 2015, 9:20 PM
Latest Blog Posts
Sceptre Airs 27", 120 Hz. 1080p Monitor/HDTV w/ 5 ms Response Time for $220
Dec 3, 2014, 10:32 PM
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
More Blog Posts
Copyright 2015 DailyTech LLC. -
Terms, Conditions & Privacy Information