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Researchers hope to use the new information about the KLF14 gene to control type 2 diabetes and obesity  (Source: bacterialvagi.us)
A study of 800 UK female twins shows that the mother's copy of the gene provides the ability to control other genes associated with metabolic traits

Researchers from the University of Oxford and King's College London have made a crucial discovery that could lead to the development of better treatments and maybe even a cure for type 2 diabetes and obesity.

Professor Tim Spector, study leader from the Department of Twin Research at King's College London, and Professor Mark McCarthy, co-author of the University of Oxford, have determined how a previously discovered gene that is linked to type 2 diabetes and cholesterol acts as a regulator for the gene's that reside within the body's fat. 

KLF14 has been linked to type 2 diabetes and cholesterol levels in previous studies. But now, scientists have figured out how this gene acts as a regulator for genes located in far-away body fat.

"KLF14 seems to act as a master switch controlling processes that connect changes in the behavior of subcutaneous fat to disturbances in muscle and liver that contribute to diabetes and other conditions," said McCarthy. "We are working hard right now to understand these processes and how we can use this information to improve treatment of these conditions." 

A child inherits a set of genes from both the mother and the father. In this study, researchers found that the KLF14 gene inherited its activity from the mother while the father's KLF14 gene remains inactive. The KLF14's ability to control distant genes in the body's fat is completely dependent on the mother's version. 

They discovered that the mother's KLF14 gene controls other genes associated with body-mass index (obesity), insulin, glucose levels and cholesterol. This means that KLF14 is a "master switch" that controls and shows the connections between metabolic traits.

Researchers made this discovery by recruiting 800 UK female twin participants and studying over 20,000 genes in subcutaneous fat biopsies. They also looked at genes in subcutaneous fat biopsies from Icelandic participants. Between the two studies, researchers discovered the connections between the KLF14 gene and distant genes associated with metabolic traits.  

"This is the first major study that shows how small changes in one master regulator gene can cause a cascade of other metabolic effects in other genes," said Spector. "This has great therapeutic potential particularly as by studying large detailed populations such as the twins we hope to find more of these regulators." 

This study was published in Nature Genetics, and is part of multinational collaboration funded by the Wellcome Trust called the MuTHER study. 



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Real reason
By NICOXIS on 5/16/2011 3:30:24 PM , Rating: 2
People are obese because they eat more than their body use, period.

The fact that one person can be obese and another thin while eating the exact same amounts is given by a combination of factors:


- Metabolism
- Calorie spending
- Calorie intake

It's not sufficient to just take on one of the above, because it would be unbalanced. And this should always be a way of life, not just a project or temporary thing.

For example, if you are only doing lots of sports which elevates calorie spending and is healthy for your overall system, there always comes a time when you need to stop or lower the amount. What happens then is your body will be "trained" to metabolize as much food as possible so it haves enough energy available for these activities. So if you maintain the same diet, your body will quickly gain the lost weight due to the former activities.

What should one do then?

- Calculate the amount of base calorie spending (given by metabolism)
- Calculate the target calorie intake.
- Calculate the amount of additional activities to surpass the calorie intake (if you want to loose weight) or make it equal (maintain weight).

Eating a healthy diet is another huge different topic, this is just to control weight.




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