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Researchers hope to use the new information about the KLF14 gene to control type 2 diabetes and obesity  (Source: bacterialvagi.us)
A study of 800 UK female twins shows that the mother's copy of the gene provides the ability to control other genes associated with metabolic traits

Researchers from the University of Oxford and King's College London have made a crucial discovery that could lead to the development of better treatments and maybe even a cure for type 2 diabetes and obesity.

Professor Tim Spector, study leader from the Department of Twin Research at King's College London, and Professor Mark McCarthy, co-author of the University of Oxford, have determined how a previously discovered gene that is linked to type 2 diabetes and cholesterol acts as a regulator for the gene's that reside within the body's fat. 

KLF14 has been linked to type 2 diabetes and cholesterol levels in previous studies. But now, scientists have figured out how this gene acts as a regulator for genes located in far-away body fat.

"KLF14 seems to act as a master switch controlling processes that connect changes in the behavior of subcutaneous fat to disturbances in muscle and liver that contribute to diabetes and other conditions," said McCarthy. "We are working hard right now to understand these processes and how we can use this information to improve treatment of these conditions." 

A child inherits a set of genes from both the mother and the father. In this study, researchers found that the KLF14 gene inherited its activity from the mother while the father's KLF14 gene remains inactive. The KLF14's ability to control distant genes in the body's fat is completely dependent on the mother's version. 

They discovered that the mother's KLF14 gene controls other genes associated with body-mass index (obesity), insulin, glucose levels and cholesterol. This means that KLF14 is a "master switch" that controls and shows the connections between metabolic traits.

Researchers made this discovery by recruiting 800 UK female twin participants and studying over 20,000 genes in subcutaneous fat biopsies. They also looked at genes in subcutaneous fat biopsies from Icelandic participants. Between the two studies, researchers discovered the connections between the KLF14 gene and distant genes associated with metabolic traits.  

"This is the first major study that shows how small changes in one master regulator gene can cause a cascade of other metabolic effects in other genes," said Spector. "This has great therapeutic potential particularly as by studying large detailed populations such as the twins we hope to find more of these regulators." 

This study was published in Nature Genetics, and is part of multinational collaboration funded by the Wellcome Trust called the MuTHER study. 



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RE: news flash
By Spuke on 5/16/2011 3:28:25 PM , Rating: 2
quote:
It takes 6-8 weeks of serious weight training just to start losing the fat and gaining muscle.
Good to know. I always wondered why it took so long to even begin to gain muscle. If people could get past this hump, they would be really motivated to continue.


RE: news flash
By jkostans on 5/16/2011 5:02:28 PM , Rating: 3
It's true, once you get past that 6-8 week hump you will start seeing results. People don't think they should have to work out 6 days a week 45 mins for 8 weeks to get results so they blame their genes. Also, if you don't feel TOTALLY exhausted after a workout (mild nausea is a good indication) then you need to step up your intensity.


RE: news flash
By dsumanik on 5/17/2011 12:31:34 PM , Rating: 2
Ill tell you all the fat "secret" you become overweight because you are eating more calories than you are burning. The end.

I dont care how "active" a person considers their lifestyle. Lifting 80 lb boxes is not a big deal, playing hockey twice a week is not a big deal.

You need to push yourself to the point of exhaustion at least once a day and control your diet...FOREVER.

I dont want to see a "cure found" for obesity.

Overeating and laziness should not be rewarded with a majic pill that makes you magically have a perfect body.

Id personally like to see substantial tax breaks for healthy poeple who dont smoke, and tax penalties for those who arent.


"Young lady, in this house we obey the laws of thermodynamics!" -- Homer Simpson














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